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    Tp53bp2 tumor protein p53 binding protein, 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305025, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tp53bp2provided by RGD
    Official Full Name
    tumor protein p53 binding protein, 2provided by RGD
    Primary source
    RGD:1305461
    See related
    EnsemblRapid:ENSRNOG00000003237 AllianceGenome:RGD:1305461
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Trp53bp2
    Summary
    Predicted to enable NF-kappaB binding activity; p53 binding activity; and protein homodimerization activity. Predicted to be involved in intrinsic apoptotic signaling pathway by p53 class mediator and positive regulation of execution phase of apoptosis. Predicted to act upstream of or within several processes, including embryo development; heart development; and response to ionizing radiation. Predicted to be located in cell junction; cytosol; and perinuclear region of cytoplasm. Predicted to be active in nucleus. Orthologous to human TP53BP2 (tumor protein p53 binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 126.8), Thymus (RPKM 74.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tp53bp2 in Genome Data Viewer
    Location:
    13q26
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (96620429..96677090)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (94088769..94145436)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (100817206..100873837)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352584 Neighboring gene delta(4)-desaturase, sphingolipid 1 Neighboring gene F-box protein 28 Neighboring gene uncharacterized LOC102555308 Neighboring gene calpain 2 Neighboring gene uncharacterized LOC120096330

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The DEAD box protein Ddx42p modulates the function of ASPP2, a stimulator of apoptosis. Uhlmann-Schiffler H, et al. Oncogene, 2009 May 21. PMID 19377511
    2. ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth. Vives V, et al. Genes Dev, 2006 May 15. PMID 16702401, Free PMC Article
    3. APCL, a central nervous system-specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53-binding protein 2 and translocates it to the perinucleus. Nakagawa H, et al. Cancer Res, 2000 Jan 1. PMID 10646860
    4. The structure and interactions of the proline-rich domain of ASPP2. Rotem S, et al. J Biol Chem, 2008 Jul 4. PMID 18448430
    5. Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis. Cao Y, et al. Biochem Biophys Res Commun, 2004 Mar 19. PMID 14985081

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NF-kappaB binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables p53 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within central nervous system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryo development ending in birth or egg hatching ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of execution phase of apoptosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    apoptosis-stimulating of p53 protein 2
    Names
    transformation related protein 53 binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427417.1 → NP_001414346.1  apoptosis-stimulating of p53 protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      F1M5H6
      Related
      ENSRNOP00000004330.6, ENSRNOT00000004330.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      96620429..96677090
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091490.2 → XP_038947418.1  apoptosis-stimulating of p53 protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ANU5, A6JGL8
      Conserved Domains (6) summary
      PHA03247
      Location:332 → 731
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:128 → 330
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      sd00045
      Location:914 → 940
      ANK; ANK repeat [structural motif]
      cd17225
      Location:10 → 89
      RA_ASPP2; Ras-associating (RA) domain found in apoptosis-stimulating protein of p53 protein 2 (ASPP2)
      pfam12796
      Location:914 → 1000
      Ank_2; Ankyrin repeats (3 copies)
      cl17036
      Location:1044 → 1100
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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