Hvcn1 hydrogen voltage-gated channel 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hvcn1provided by RGD
Official Full Name: hydrogen voltage-gated channel 1provided by RGD
Primary source: RGD:1310788
See related: EnsemblRapid:ENSRNOG00000001270 AllianceGenome:RGD:1310788
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1310788
Summary: Predicted to enable protein homodimerization activity and voltage-gated proton channel activity. Involved in positive regulation of superoxide anion generation and regulation of intracellular pH. Located in apical plasma membrane. Used to study middle cerebral artery infarction. Orthologous to human HVCN1 (hydrogen voltage gated channel 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Spleen (RPKM 208.5), Lung (RPKM 62.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (40001205..40030671, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (34341673..34370010, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (39822814..39851093, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HV1 contributes to the development of hypertension and renal disease in Dahl salt-sensitive rats. It acts as a sodium sensor and promotes superoxide production in medullary thick ascending limb of Dahl salt-sensitive rats.
Title: HV1 acts as a sodium sensor and promotes superoxide production in medullary thick ascending limb of Dahl salt-sensitive rats.

Submit: New GeneRIF Correction

General gene information

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Markers

RH142503 (e-PCR)
- UniSTS:231750

BF403268 (e-PCR)
- UniSTS:246370

AU046881 (e-PCR)
- UniSTS:111048

RH130165 (e-PCR)
- UniSTS:213452

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated proton channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated proton channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to pH	ISO Inferred from Sequence Orthology more info
involved_in cellular response to zinc ion	ISO Inferred from Sequence Orthology more info
involved_in metal ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of superoxide anion generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proton transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in proton transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of acrosome reaction	ISO Inferred from Sequence Orthology more info
involved_in regulation of intracellular pH	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of intracellular pH	ISO Inferred from Sequence Orthology more info
involved_in regulation of reactive oxygen species biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in response to pH	ISO Inferred from Sequence Orthology more info
involved_in response to zinc ion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: hydrogen voltage-gated channel 1; voltage-gated hydrogen channel 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001431735.1 → NP_001418664.1 hydrogen voltage-gated channel 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

D3ZIU8
NM_001431736.1 → NP_001418665.1 hydrogen voltage-gated channel 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

D3ZIU8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

40001205..40030671 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017598518.3 → XP_017454007.1 voltage-gated hydrogen channel 1 isoform X1

Related

ENSRNOP00000107152.1, ENSRNOT00000130199.1

Conserved Domains (1) summary

pfam16799
Location:224 → 271

VGPC1_C; C-terminal membrane-localization domain of ion-channel, VCN1
XM_063271892.1 → XP_063127962.1 voltage-gated hydrogen channel 1 isoform X2

Related

ENSRNOP00000110311.1, ENSRNOT00000136202.1