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    Ap4m1 adaptor related protein complex 4 subunit mu 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304344, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ap4m1provided by RGD
    Official Full Name
    adaptor related protein complex 4 subunit mu 1provided by RGD
    Primary source
    RGD:1310233
    See related
    EnsemblRapid:ENSRNOG00000001353 AllianceGenome:RGD:1310233
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein domain specific binding activity. Predicted to be involved in several processes, including post-Golgi vesicle-mediated transport; protein localization to basolateral plasma membrane; and protein targeting to lysosome. Predicted to be located in early endosome. Predicted to be part of AP-4 adaptor complex. Predicted to be active in cytoplasmic vesicle and trans-Golgi network. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 50. Orthologous to human AP4M1 (adaptor related protein complex 4 subunit mu 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 97.2), Adrenal (RPKM 88.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ap4m1 in Genome Data Viewer
    Location:
    12q11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (22163474..22171734)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (17049766..17055954)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (19314222..19320339)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene microRNA 106b Neighboring gene minichromosome maintenance complex component 7 Neighboring gene microRNA 93 Neighboring gene TATA-box binding protein associated factor 6 Neighboring gene canopy FGF signaling regulator 4 Neighboring gene metallo-beta-lactamase domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. AP4M1 is abnormally expressed in oxygen-glucose deprived hippocampal neurons. Zhang J, et al. Neurosci Lett, 2014 Mar 20. PMID 24486887
    2. Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex. Burgos PV, et al. Dev Cell, 2010 Mar 16. PMID 20230749, Free PMC Article
    3. AP-4 binds basolateral signals and participates in basolateral sorting in epithelial MDCK cells. Simmen T, et al. Nat Cell Biol, 2002 Feb. PMID 11802162
    4. Signal-binding specificity of the mu4 subunit of the adaptor protein complex AP-4. Aguilar RC, et al. J Biol Chem, 2001 Apr 20. PMID 11139587
    5. Association between Rare Variants in AP4E1, a Component of Intracellular Trafficking, and Persistent Stuttering. Raza MH, et al. Am J Hum Genet, 2015 Nov 5. PMID 26544806, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156474

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to endosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi to endosome transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in Golgi to lysosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi to lysosome transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in autophagosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein targeting IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein targeting to lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-4 adaptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of AP-4 adaptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    AP-4 complex subunit mu-1
    Names
    AP-4 adapter complex mu subunit
    AP-4 adaptor complex mu subunit
    adapter-related protein complex 4 mu-1 subunit
    adapter-related protein complex 4 subunit mu-1
    adaptor-related protein complex 4, mu 1 subunit
    adaptor-related protein complex AP-4, mu 1
    mu subunit of AP-4
    mu-ARP2
    mu-adaptin-related protein 2
    mu4
    mu4-adaptin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037977.3 → NP_001033066.1  AP-4 complex subunit mu-1 isoform 1

      See identical proteins and their annotated locations for NP_001033066.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      Q2PWT8
      UniProtKB/TrEMBL
      A0A8I6B231, A6KST1
      Conserved Domains (2) summary
      cl02092
      Location:1 → 130
      Clat_adaptor_s; Clathrin adaptor complex small chain
      cd09253
      Location:175 → 453
      AP-4_Mu4_Cterm; C-terminal domain of medium Mu4 subunit in adaptor protein (AP) complex AP-4

    2. NM_001413271.2 → NP_001400200.1  AP-4 complex subunit mu-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      22163474..22171734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271278.1 → XP_063127348.1  AP-4 complex subunit mu-1 isoform X3

    2. XM_006249008.4 → XP_006249070.1  AP-4 complex subunit mu-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6B231
      Related
      ENSRNOP00000001827.3, ENSRNOT00000001827.6
      Conserved Domains (2) summary
      cl02092
      Location:1 → 130
      Clat_adaptor_s; Clathrin adaptor complex small chain
      cd09253
      Location:175 → 457
      AP-4_Mu4_Cterm; C-terminal domain of medium Mu4 subunit in adaptor protein (AP) complex AP-4

    3. XM_039089411.2 → XP_038945339.1  AP-4 complex subunit mu-1 isoform X2

      Conserved Domains (1) summary
      cd09253
      Location:47 → 329
      AP-4_Mu4_Cterm; C-terminal domain of medium Mu4 subunit in adaptor protein (AP) complex AP-4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2PWT8.1 GenPept UniProtKB/Swiss-Prot:Q2PWT8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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