Nrip1 nuclear receptor interacting protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nrip1provided by RGD
Official Full Name: nuclear receptor interacting protein 1provided by RGD
Primary source: RGD:1311850
See related: EnsemblRapid:ENSRNOG00000001585 AllianceGenome:RGD:1311850
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RIP140
Summary: Enables nuclear estrogen receptor binding activity. Predicted to be involved in several processes, including cellular response to estradiol stimulus; ovarian follicle rupture; and regulation of gene expression. Predicted to act upstream of or within regulation of transcription by RNA polymerase II. Predicted to be located in chromatin; cytosol; and nuclear lumen. Predicted to be part of histone deacetylase complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in CAKUT and osteoporosis. Orthologous to human NRIP1 (nuclear receptor interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 248.7), Adrenal (RPKM 215.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11p11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (28382835..28466483, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (14895843..14979490, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (14658225..14742478, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RIP140 aggravates metabolic repression, mitochondrial malfunction, and further accelerates the transition to heart failure in response to myocardial infarction stress.
Title: Receptor-interacting protein 140 overexpression impairs cardiac mitochondrial function and accelerates the transition to heart failure in chronically infarcted rats.
This study indicates that suppression of SIRT3 by RIP140 facilitates the development of cardiomyocyte hypertrophy, mitochondrial dysfunction and energy metabolic dysfunction.
Title: Receptor-interacting Protein 140 represses Sirtuin 3 to facilitate hypertrophy, mitochondrial dysfunction and energy metabolic dysfunction in cardiomyocytes.
overexpression of RIP140 induced proinflammatory gene expression and cytokine release in neonatal cardiomyocytes, which could be reversed by p65-NF-kappaB inhibition
Title: The p65 subunit of NF-κB involves in RIP140-mediated inflammatory and metabolic dysregulation in cardiomyocytes.
In skeletal muscle cells, RIP140 expression significantly impacts palmitate uptake and oxidation and that alterations in gene expression and Akt-atypical protein kinaseC-theta signalling can partly explain these changes.
Title: Genetic downregulation of receptor-interacting protein 140 uncovers the central role of Akt signalling in the regulation of fatty acid oxidation in skeletal muscle cells.
RIP140 and PGC-1alpha exert an antagonistic role in regulating cardiac energy state and mitochondrial biogenesis.
Title: Roles of transcriptional corepressor RIP140 and coactivator PGC-1α in energy state of chronically infarcted rat hearts and mitochondrial function of cardiomyocytes.
RIP140 protein was down-regulated in white adipose tissue of rats with ovariectomy-induced obesity.
Title: The role of receptor-interacting protein 140 in the accumulation of fat in ovariectomised rats.
Decreased RIP140 protein content not required for exercise and AMPK-dependent increases in skeletal muscle mitochondrial content.
Title: Reductions in RIP140 are not required for exercise- and AICAR-mediated increases in skeletal muscle mitochondrial content.
The lack of an effect of beta-GPA feeding on mitochondrial proteins in the soleus muscles could be related to a fiber type-specific effect of beta-GPA on RIP140 protein content
Title: Muscle-specific differences in the response of mitochondrial proteins to beta-GPA feeding: an evaluation of potential mechanisms.

Submit: New GeneRIF Correction

General gene information

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Markers

Nrip1 (e-PCR), detects polymorphism
- UniSTS:259113

RH133591 (e-PCR)
- UniSTS:216874

BI302296 (e-PCR)
- UniSTS:247633

AF053062 (e-PCR)
- UniSTS:163578

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables nuclear estrogen receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear estrogen receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear glucocorticoid receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear glucocorticoid receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear retinoic acid receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear retinoid X receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear retinoid X receptor binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cellular response to estradiol stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to estradiol stimulus	ISO Inferred from Sequence Orthology more info
involved_in circadian regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in circadian regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in lipid storage	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in ovarian follicle rupture	ISO Inferred from Sequence Orthology more info
involved_in ovulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
part_of histone deacetylase complex	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nuclear receptor-interacting protein 1

Names: receptor-interacting protein 140

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100560.2 → NP_001094030.1 nuclear receptor-interacting protein 1

See identical proteins and their annotated locations for NP_001094030.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

A6JL20, G3V672

Related

ENSRNOP00000092566.1, ENSRNOT00000094986.2

Conserved Domains (4) summary

pfam15687
Location:27 → 331

NRIP1_repr_1; Nuclear receptor-interacting protein 1 repression 1

pfam15688
Location:413 → 738

NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2

pfam15689
Location:755 → 842

NRIP1_repr_3; Nuclear receptor-interacting protein 1 repression 3

pfam15690
Location:851 → 1162

NRIP1_repr_4; Nuclear receptor-interacting protein 1 repression 4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

28382835..28466483 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039088449.2 → XP_038944377.1 nuclear receptor-interacting protein 1 isoform X1

UniProtKB/TrEMBL

A6JL20, G3V672

Related

ENSRNOP00000077848.1, ENSRNOT00000103187.2

Conserved Domains (4) summary

pfam15687
Location:27 → 331

NRIP1_repr_1; Nuclear receptor-interacting protein 1 repression 1

pfam15688
Location:413 → 738

NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2

pfam15689
Location:755 → 842

NRIP1_repr_3; Nuclear receptor-interacting protein 1 repression 3

pfam15690
Location:851 → 1162

NRIP1_repr_4; Nuclear receptor-interacting protein 1 repression 4
XM_039088447.2 → XP_038944375.1 nuclear receptor-interacting protein 1 isoform X1

UniProtKB/TrEMBL

A6JL20, G3V672

Related

ENSRNOP00000077049.1, ENSRNOT00000118675.2

Conserved Domains (4) summary

pfam15687
Location:27 → 331

NRIP1_repr_1; Nuclear receptor-interacting protein 1 repression 1

pfam15688
Location:413 → 738

NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2

pfam15689
Location:755 → 842

NRIP1_repr_3; Nuclear receptor-interacting protein 1 repression 3

pfam15690
Location:851 → 1162

NRIP1_repr_4; Nuclear receptor-interacting protein 1 repression 4
XM_039088446.2 → XP_038944374.1 nuclear receptor-interacting protein 1 isoform X1

UniProtKB/TrEMBL

A6JL20, G3V672

Related

ENSRNOP00000080753.1, ENSRNOT00000101761.2

Conserved Domains (4) summary

pfam15687
Location:27 → 331

NRIP1_repr_1; Nuclear receptor-interacting protein 1 repression 1

pfam15688
Location:413 → 738

NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2

pfam15689
Location:755 → 842

NRIP1_repr_3; Nuclear receptor-interacting protein 1 repression 3

pfam15690
Location:851 → 1162

NRIP1_repr_4; Nuclear receptor-interacting protein 1 repression 4
XM_039088448.2 → XP_038944376.1 nuclear receptor-interacting protein 1 isoform X1

UniProtKB/TrEMBL

A6JL20, G3V672

Related

ENSRNOP00000112216.1, ENSRNOT00000148776.1

Conserved Domains (4) summary

pfam15687
Location:27 → 331

NRIP1_repr_1; Nuclear receptor-interacting protein 1 repression 1

pfam15688
Location:413 → 738

NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2

pfam15689
Location:755 → 842

NRIP1_repr_3; Nuclear receptor-interacting protein 1 repression 3

pfam15690
Location:851 → 1162

NRIP1_repr_4; Nuclear receptor-interacting protein 1 repression 4
XM_063270607.1 → XP_063126677.1 nuclear receptor-interacting protein 1 isoform X1

UniProtKB/TrEMBL

A6JL20, G3V672