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    Marchf10 membrane associated ring-CH-type finger 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303596, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Marchf10provided by RGD
    Official Full Name
    membrane associated ring-CH-type finger 10provided by RGD
    Primary source
    RGD:1311692
    See related
    EnsemblRapid:ENSRNOG00000007084 AllianceGenome:RGD:1311692
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rnf190; MARCH-X; March10; RGD1311692
    Summary
    Predicted to enable ligase activity; transferase activity; and zinc ion binding activity. Predicted to be involved in protein ubiquitination. Orthologous to human MARCHF10 (membrane associated ring-CH-type finger 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 558.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    10q32.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (90832647..90975700, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (90332783..90423109, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (93591187..93681507, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095186 Neighboring gene uncharacterized LOC120095187 Neighboring gene mannose receptor, C type 2 Neighboring gene uncharacterized LOC120095189 Neighboring gene uncharacterized LOC108352144 Neighboring gene uncharacterized LOC134480889 Neighboring gene transfer RNA valine (anticodon AAC) 25

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Membrane-associated RING-CH 10 (MARCH10 protein) is a microtubule-associated E3 ubiquitin ligase of the spermatid flagella. Iyengar PV, et al. J Biol Chem, 2011 Nov 11. PMID 21937444, Free PMC Article
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable E3 ubiquitin-protein ligase MARCHF10
    Names
    RING-type E3 ubiquitin transferase MARCH10
    RING-type E3 ubiquitin transferase MARCHF10
    membrane-associated RING finger protein 10
    membrane-associated RING-CH protein X
    membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
    microtubule-associated E3 ubiquitin ligase
    probable E3 ubiquitin-protein ligase MARCH10
    ring finger protein 190
    NP_001013995.1
    XP_017452827.1
    XP_017452829.1
    XP_038942071.1
    XP_038942073.2
    XP_063125263.1
    XP_063125264.1
    XP_063125265.1
    XP_063125266.1
    XP_063125267.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013973.2 → NP_001013995.1  probable E3 ubiquitin-protein ligase MARCHF10

      See identical proteins and their annotated locations for NP_001013995.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q5XIV2
      UniProtKB/TrEMBL
      G3XDV3
      Related
      ENSRNOP00000009316.5, ENSRNOT00000009316.9
      Conserved Domains (1) summary
      cd16813
      Location:641 → 700
      RING_CH-C4HC3_MARCH10; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH10 (MARCH10)

    2. NM_001428757.1 → NP_001415686.1  probable E3 ubiquitin-protein ligase MARCHF10

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q5XIV2
      UniProtKB/TrEMBL
      G3XDV3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      90832647..90975700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086143.2 → XP_038942071.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X2

      Conserved Domains (1) summary
      cd16813
      Location:641 → 700
      RING_CH-C4HC3_MARCH10; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH10 (MARCH10)

    2. XM_017597338.3 → XP_017452827.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X2

      UniProtKB/Swiss-Prot
      Q5XIV2
      UniProtKB/TrEMBL
      G3XDV3
      Conserved Domains (1) summary
      cd16813
      Location:641 → 700
      RING_CH-C4HC3_MARCH10; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH10 (MARCH10)

    3. XM_063269194.1 → XP_063125264.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X3

    4. XM_063269193.1 → XP_063125263.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X1

    5. XM_039086145.2 → XP_038942073.2  probable E3 ubiquitin-protein ligase MARCHF10 isoform X4

    6. XM_063269196.1 → XP_063125266.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X5

    7. XM_017597340.3 → XP_017452829.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X5

    8. XM_063269195.1 → XP_063125265.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X5

      Related
      ENSRNOP00000072446.1, ENSRNOT00000090662.3

    9. XM_063269197.1 → XP_063125267.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K2Z8, A6HJY2, A6HJY3, D3ZAX0
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIV2.1 GenPept UniProtKB/Swiss-Prot:Q5XIV2

    Gene LinkOut

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