Aff4 ALF transcription elongation factor 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aff4provided by RGD
Official Full Name: ALF transcription elongation factor 4provided by RGD
Primary source: RGD:1311694
See related: EnsemblRapid:ENSRNOG00000006965 AllianceGenome:RGD:1311694
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Laf4l
Summary: Involved in response to endoplasmic reticulum stress. Predicted to be located in euchromatin; fibrillar center; and nucleoplasm. Predicted to be part of super elongation complex. Orthologous to human AFF4 (ALF transcription elongation factor 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 277.6), Brain (RPKM 276.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (37998319..38080580)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (37498825..37579751)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (38692167..38773021)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

REN72054 (e-PCR)
- UniSTS:396854

SGC32016 (e-PCR)
- UniSTS:59709

MARC_16763-16764:1020874272:1 (e-PCR)
- UniSTS:268105

AU047273 (e-PCR)
- UniSTS:110671

Aff4 (e-PCR), detects polymorphism
- UniSTS:506718

RH142595 (e-PCR)
- UniSTS:231842

stSG601610 (e-PCR)
- UniSTS:444395

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to endoplasmic reticulum stress	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within spermatid development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in euchromatin	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of super elongation complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription elongation factor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: AF4/FMR2 family member 4

Names: AF4/FMR2 family, member 4; lymphoid nuclear protein related to AF4-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.