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    F8 coagulation factor VIII [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302470, updated on 2-Nov-2024

    Summary

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    Official Symbol
    F8provided by RGD
    Official Full Name
    coagulation factor VIIIprovided by RGD
    Primary source
    RGD:727845
    See related
    EnsemblRapid:ENSRNOG00000031197 AllianceGenome:RGD:727845
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable copper ion binding activity and oxidoreductase activity. Involved in blood coagulation, intrinsic pathway. Located in extracellular space. Used to study factor VIII deficiency; hemarthrosis; and hyperhomocysteinemia. Human ortholog(s) of this gene implicated in factor VIII deficiency. Orthologous to human F8 (coagulation factor VIII). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 92.8), Heart (RPKM 64.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    18p13
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (155237..187186)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (140848..172330)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (367862..399242, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene BRCA1/BRCA2-containing complex, subunit 3, pseudogene 7 Neighboring gene FUN14 domain containing 2 Neighboring gene uncharacterized LOC134482991 Neighboring gene mature T-cell proliferation 1 Neighboring gene C-X9-C motif containing 4 Neighboring gene uncharacterized LOC134482992 Neighboring gene myotubularin related protein 1 Neighboring gene zinc finger protein 91, pseudogene 2 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Altered collagen turnover in factor VIII-deficient rats with hemophilic arthropathy identifies potential novel serological biomarkers in hemophilia. Manon-Jensen T, et al. J Thromb Haemost, 2016 Dec. PMID 27681457
    2. Secretion of coagulant factor VIII activity and antigen by in vitro cultivated rat liver sinusoidal endothelial cells. Hellman L, et al. Br J Haematol, 1989 Nov. PMID 2513867
    3. Long-term expression of human coagulation factor VIII and correction of hemophilia A after in vivo retroviral gene transfer in factor VIII-deficient mice. VandenDriessche T, et al. Proc Natl Acad Sci U S A, 1999 Aug 31. PMID 10468616, Free PMC Article
    4. Sequence of the rat factor VIII cDNA. Watzka M, et al. Thromb Haemost, 2004 Jan. PMID 14691566
    5. The severe spontaneous bleeding phenotype in a novel hemophilia A rat model is rescued by platelet FVIII expression. Shi Q, et al. Blood Adv, 2020 Jan 14. PMID 31899798, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of a F8(-/-) rat model of hemophilic arthropathy reveals that collagen turnover is altered
      Title: Altered collagen turnover in factor VIII-deficient rats with hemophilic arthropathy identifies potential novel serological biomarkers in hemophilia.
    2. analysis of animal models for hemophilia A and the advantage of rats over mice in the factor VIII gene mutation model
      Title: WAG-F8(m1Ycb) rats harboring a factor VIII gene mutation provide a new animal model for hemophilia A.
    3. Sequence of the rat factor VIII cDNA
      Title: Sequence of the rat factor VIII cDNA.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in blood coagulation, intrinsic pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in blood coagulation, intrinsic pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    coagulation factor VIII
    Names
    coagulation factor VIII, procoagulant component

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183331.2 → NP_899160.2  coagulation factor VIII precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      D3ZEB1, Q7TN96
      Related
      ENSRNOP00000050792.5, ENSRNOT00000045926.6
      Conserved Domains (2) summary
      cd00057
      Location:2103 → 2251
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cl19115
      Location:387 → 563
      Cupredoxin; Cupredoxin superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      155237..187186
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277282.1 → XP_063133352.1  coagulation factor VIII isoform X1

    2. XM_063277283.1 → XP_063133353.1  coagulation factor VIII isoform X2

    3. XM_039096756.2 → XP_038952684.1  coagulation factor VIII isoform X3

      UniProtKB/TrEMBL
      Q7TN96
      Conserved Domains (1) summary
      cl19115
      Location:387 → 563
      Cupredoxin; Cupredoxin superfamily

    4. XM_039096757.2 → XP_038952685.1  coagulation factor VIII isoform X4

      Conserved Domains (1) summary
      cl19115
      Location:387 → 563
      Cupredoxin; Cupredoxin superfamily

    5. XM_063277284.1 → XP_063133354.1  coagulation factor VIII isoform X5

    6. XM_063277285.1 → XP_063133355.1  coagulation factor VIII isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Chemical Information
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    Research Materials