Pi15 peptidase inhibitor 15 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pi15provided by RGD
Official Full Name: peptidase inhibitor 15provided by RGD
Primary source: RGD:1309577
See related: EnsemblRapid:ENSRNOG00000017686 AllianceGenome:RGD:1309577
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable peptidase inhibitor activity. Predicted to be involved in negative regulation of peptidase activity. Predicted to be active in extracellular space. Orthologous to human PI15 (peptidase inhibitor 15). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Uterus (RPKM 287.2), Heart (RPKM 59.4) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (6178427..6206548, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (1395094..1423213, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (791137..819233, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Decreased aortic Pi15 expression, at some point can lead to the development of the abdominal aortic internal elastic lamina ruptures.
Title: Protease inhibitor 15, a candidate gene for abdominal aortic internal elastic lamina ruptures in the rat.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: peptidase inhibitor 15

Names: protease inhibitor 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106917.1 → NP_001100387.1 peptidase inhibitor 15 precursor

See identical proteins and their annotated locations for NP_001100387.1

Status: PROVISIONAL

Source sequence(s)

CH473984

UniProtKB/TrEMBL

A6JF87, F1M2W7

Related

ENSRNOP00000023899.6, ENSRNOT00000023899.7

Conserved Domains (1) summary

cd05380
Location:69 → 212

SCP_euk; SCP_euk: SCP-like extracellular protein domain, as found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5 from vespid venom. It has been proposed ...