Pard3b par-3 family cell polarity regulator beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pard3bprovided by RGD
Official Full Name: par-3 family cell polarity regulator betaprovided by RGD
Primary source: RGD:1584992
See related: EnsemblRapid:ENSRNOG00000024345 AllianceGenome:RGD:1584992
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in several processes, including establishment of cell polarity; establishment of centrosome localization; and establishment or maintenance of epithelial cell apical/basal polarity. Predicted to be located in cell junction. Predicted to be part of protein-containing complex. Predicted to be active in several cellular components, including adherens junction; apical junction complex; and apical plasma membrane. Orthologous to human PARD3B (par-3 family cell polarity regulator beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 119.1), Heart (RPKM 117.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q32

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (70532358..71561044)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (63038435..64067178)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (68414339..69426226)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH144246 (e-PCR)
- UniSTS:233491

AU047327 (e-PCR)
- UniSTS:110617

D9Got66 (e-PCR)
- UniSTS:112182

RH133643 (e-PCR)
- UniSTS:216926

D9Got67 (e-PCR)
- UniSTS:112990

BE120687 (e-PCR)
- UniSTS:247417

MARC_21133-21134:1025201105:1 (e-PCR)
- UniSTS:268488

D9Rat117 (e-PCR), detects polymorphism
- UniSTS:228322

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of centrosome localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in apical junction complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: partitioning defective 3 homolog B

Names: par-3 partitioning defective 3 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191808.3 → NP_001178737.1 partitioning defective 3 homolog B

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A8I5ZQH3, A0A8I6A8L0

Related

ENSRNOP00000109415.1, ENSRNOT00000138401.1

Conserved Domains (3) summary

smart00228
Location:380 → 469

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:501 → 589

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:1 → 143

DUF3534; Domain of unknown function (DUF3534)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

70532358..71561044

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039083322.2 → XP_038939250.1 partitioning defective 3 homolog B isoform X1

UniProtKB/TrEMBL

F1LW22

Related

ENSRNOP00000039831.6, ENSRNOT00000040778.6

Conserved Domains (3) summary

smart00228
Location:380 → 469

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:501 → 589

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:2 → 83

DUF3534; N-terminal of Par3 and HAL proteins
XM_063266952.1 → XP_063123022.1 partitioning defective 3 homolog B isoform X2