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    Hibch 3-hydroxyisobutyryl-CoA hydrolase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301384, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Hibchprovided by RGD
    Official Full Name
    3-hydroxyisobutyryl-CoA hydrolaseprovided by RGD
    Primary source
    RGD:1308392
    See related
    EnsemblRapid:ENSRNOG00000028557 AllianceGenome:RGD:1308392
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 3-hydroxyisobutyryl-CoA hydrolase activity. Predicted to be involved in valine catabolic process. Predicted to be active in mitochondrion. Orthologous to human HIBCH (3-hydroxyisobutyryl-CoA hydrolase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 238.2), Liver (RPKM 169.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hibch in Genome Data Viewer
    Location:
    9q22
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (56082082..56161796, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (48590097..48669896, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (53446185..53526727, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 2 open reading frame 88 Neighboring gene serine and arginine rich splicing factor 7, pseudogene 4 Neighboring gene inositol polyphosphate-1-phosphatase Neighboring gene post-GPI attachment to proteins 2, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Purification and partial characterization of 3-hydroxyisobutyryl-coenzyme A hydrolase of rat liver. Shimomura Y, et al. J Biol Chem, 1994 May 13. PMID 8188708
    2. Primary structure and tissue-specific expression of human beta-hydroxyisobutyryl-coenzyme A hydrolase. Hawes JW, et al. J Biol Chem, 1996 Oct 18. PMID 8824301
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-hydroxyisobutyryl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-hydroxyisobutyryl-CoA hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3-hydroxyisobutyryl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in valine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in valine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
    Names
    3-hydroxyisobutyryl-Coenzyme A hydrolase
    HIB-CoA hydrolase
    HIBYL-CoA-H
    NP_001013130.1
    NP_001385597.1
    XP_038939216.2
    XP_038939217.1
    XP_063123006.1
    XP_063123007.1
    XP_063123008.1
    XP_063123009.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013112.2 → NP_001013130.1  3-hydroxyisobutyryl-CoA hydrolase, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_001013130.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q5XIE6
      Related
      ENSRNOP00000046370.2, ENSRNOT00000040650.5
      Conserved Domains (1) summary
      pfam16113
      Location:46 → 296
      ECH_2; Enoyl-CoA hydratase/isomerase

    2. NM_001398668.1 → NP_001385597.1  3-hydroxyisobutyryl-CoA hydrolase, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q5XIE6
      UniProtKB/TrEMBL
      A0A8I5ZL23, A6INV5
      Related
      ENSRNOP00000032041.4, ENSRNOT00000029677.8
      Conserved Domains (1) summary
      pfam16113
      Location:46 → 374
      ECH_2; Enoyl-CoA hydratase/isomerase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      56082082..56161796 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083289.2 → XP_038939217.1  3-hydroxyisobutyryl-CoA hydrolase, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZL23
      Conserved Domains (1) summary
      pfam16113
      Location:19 → 347
      ECH_2; Enoyl-CoA hydratase/isomerase

    2. XM_063266936.1 → XP_063123006.1  3-hydroxyisobutyryl-CoA hydrolase, mitochondrial isoform X3

    3. XM_039083288.2 → XP_038939216.2  3-hydroxyisobutyryl-CoA hydrolase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZL23, A0A8I6A0J8
      Related
      ENSRNOP00000084082.2, ENSRNOT00000116077.2

    4. XM_063266938.1 → XP_063123008.1  3-hydroxyisobutyryl-CoA hydrolase, mitochondrial isoform X4

    5. XM_063266937.1 → XP_063123007.1  3-hydroxyisobutyryl-CoA hydrolase, mitochondrial isoform X4

    6. XM_063266939.1 → XP_063123009.1  3-hydroxyisobutyryl-CoA hydrolase, mitochondrial isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIE6.2 GenPept UniProtKB/Swiss-Prot:Q5XIE6

    Gene LinkOut

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