U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Dusp7 dual specificity phosphatase 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300980, updated on 28-Oct-2024

    Summary

    Official Symbol
    Dusp7provided by RGD
    Official Full Name
    dual specificity phosphatase 7provided by RGD
    Primary source
    RGD:735026
    See related
    EnsemblRapid:ENSRNOG00000010789 AllianceGenome:RGD:735026
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    mkp-X
    Summary
    Predicted to enable MAP kinase tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; and protein tyrosine/threonine phosphatase activity. Predicted to be involved in negative regulation of MAPK cascade; peptidyl-tyrosine dephosphorylation; and signal transduction. Predicted to be active in cytosol. Orthologous to human DUSP7 (dual specificity phosphatase 7). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Heart (RPKM 119.7), Lung (RPKM 98.2) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Dusp7 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (115888091..115895126)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (107009369..107016404)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (115069095..115076130)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L29 Neighboring gene uncharacterized LOC120094254 Neighboring gene 5'-aminolevulinate synthase 1 Neighboring gene POC1 centriolar protein A Neighboring gene uncharacterized LOC134480228 Neighboring gene abhydrolase domain containing 14A Neighboring gene aminoacylase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MAP kinase tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables MAP kinase tyrosine/serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables MAP kinase tyrosine/serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-tyrosine dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptidyl-tyrosine dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dual specificity protein phosphatase 7
    Names
    MAP kinase phosphatase
    dual specificity protein phosphatase MKP-X
    NP_001094017.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100547.1NP_001094017.1  dual specificity protein phosphatase 7

      See identical proteins and their annotated locations for NP_001094017.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      F1M7V9, Q63340
      Related
      ENSRNOP00000014770.5, ENSRNOT00000014770.9
      Conserved Domains (2) summary
      cd01446
      Location:55186
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
      cd14643
      Location:240388
      DSP_DUSP7; dual specificity phosphatase domain of dual specificity protein phosphatase 7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      115888091..115895126
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)