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    Tfdp2 transcription factor Dp-2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300947, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tfdp2provided by RGD
    Official Full Name
    transcription factor Dp-2provided by RGD
    Primary source
    RGD:1305814
    See related
    EnsemblRapid:ENSRNOG00000011241 AllianceGenome:RGD:1305814
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tcfdp2
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and protein domain specific binding activity. Predicted to contribute to DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in heart development. Predicted to be located in mitotic spindle and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Orthologous to human TFDP2 (transcription factor Dp-2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 168.5), Spleen (RPKM 136.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tfdp2 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (105640018..105781026)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (96760459..96901466)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (104040795..104181228)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094234 Neighboring gene 5'-3' exoribonuclease 1 Neighboring gene glycerol kinase 5 Neighboring gene uncharacterized LOC134480216 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene ATP synthase peripheral stalk-membrane subunit b, pseudogene 1 Neighboring gene 60S ribosomal protein L31-like Neighboring gene ATPase Na+/K+ transporting subunit beta 3 Neighboring gene ubiquitin conjugating enzyme E2 V1, pseudogene 21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Inhibition of E2F abrogates the development of cardiac myocyte hypertrophy. Vara D, et al. J Biol Chem, 2003 Jun 13. PMID 12682052
    2. E2F-6, a member of the E2F family that can behave as a transcriptional repressor. Trimarchi JM, et al. Proc Natl Acad Sci U S A, 1998 Mar 17. PMID 9501179, Free PMC Article
    3. Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes. Zaragoza K, et al. Mol Cell Biol, 2010 May. PMID 20176812, Free PMC Article
    4. In vivo association of E2F and DP family proteins. Wu CL, et al. Mol Cell Biol, 1995 May. PMID 7739537, Free PMC Article
    5. Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. Rubin SM, et al. Cell, 2005 Dec 16. PMID 16360038

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in heart development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor Dp-2
    Names
    transcription factor Dp-2 (E2F dimerization partner 2)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106847.3 → NP_001100317.2  transcription factor Dp-2 isoform 6

      See identical proteins and their annotated locations for NP_001100317.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5ZNQ2, B5DF82
      Related
      ENSRNOP00000085683.2, ENSRNOT00000112993.2
      Conserved Domains (3) summary
      cd14458
      Location:152 → 198
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:68 → 147
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:154 → 293
      DP; Transcription factor DP

    2. NM_001433295.1 → NP_001420224.1  transcription factor Dp-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2JXE8

    3. NM_001433296.1 → NP_001420225.1  transcription factor Dp-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2JXE8

    4. NM_001433297.1 → NP_001420226.1  transcription factor Dp-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    5. NM_001433298.1 → NP_001420227.1  transcription factor Dp-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    6. NM_001433299.1 → NP_001420228.1  transcription factor Dp-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    7. NM_001433300.1 → NP_001420229.1  transcription factor Dp-2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    8. NM_001433301.1 → NP_001420230.1  transcription factor Dp-2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      F7EWM8

    9. NM_001433302.1 → NP_001420231.1  transcription factor Dp-2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6A8L4

    10. NM_001433303.1 → NP_001420232.1  transcription factor Dp-2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6A8L4

    11. NM_001433304.1 → NP_001420233.1  transcription factor Dp-2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      B5DF82

    12. NM_001433305.1 → NP_001420234.1  transcription factor Dp-2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      B5DF82

    13. NM_001433306.1 → NP_001420235.1  transcription factor Dp-2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      105640018..105781026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595584.3 → XP_017451073.1  transcription factor Dp-2 isoform X2

      Related
      ENSRNOP00000105570.1, ENSRNOT00000159108.1
      Conserved Domains (3) summary
      cd14458
      Location:213 → 259
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:129 → 208
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:215 → 354
      DP; Transcription factor DP

    2. XM_017595583.3 → XP_017451072.1  transcription factor Dp-2 isoform X1

      Conserved Domains (3) summary
      cd14458
      Location:214 → 260
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:129 → 209
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:216 → 354
      DP; Transcription factor DP

    3. XM_006243556.5 → XP_006243618.1  transcription factor Dp-2 isoform X1

      Related
      ENSRNOP00000110225.1, ENSRNOT00000156907.1
      Conserved Domains (3) summary
      cd14458
      Location:214 → 260
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:129 → 209
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:216 → 354
      DP; Transcription factor DP

    4. XM_017595585.3 → XP_017451074.1  transcription factor Dp-2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZNQ2
      Conserved Domains (3) summary
      cd14458
      Location:214 → 260
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:129 → 209
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:216 → 355
      DP; Transcription factor DP

    5. XM_063265216.1 → XP_063121286.1  transcription factor Dp-2 isoform X5

      Related
      ENSRNOP00000089626.2, ENSRNOT00000108693.2

    6. XM_063265213.1 → XP_063121283.1  transcription factor Dp-2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JXE8

    7. XM_017595582.3 → XP_017451071.1  transcription factor Dp-2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JXE8, A0A8I5ZNQ2
      Conserved Domains (3) summary
      cd14458
      Location:214 → 260
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:129 → 209
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:216 → 354
      DP; Transcription factor DP

    8. XM_039081176.2 → XP_038937104.1  transcription factor Dp-2 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZNQ2, A0A8I6A268
      Conserved Domains (3) summary
      cd14458
      Location:154 → 200
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:69 → 149
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:156 → 294
      DP; Transcription factor DP

    9. XM_039081178.2 → XP_038937106.1  transcription factor Dp-2 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZNQ2, A0A8I6A268
      Conserved Domains (3) summary
      cd14458
      Location:154 → 200
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:69 → 149
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:156 → 294
      DP; Transcription factor DP

    10. XM_039081174.2 → XP_038937102.1  transcription factor Dp-2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JXE8, A0A8I5ZNQ2
      Conserved Domains (3) summary
      cd14458
      Location:214 → 260
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:129 → 209
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:216 → 354
      DP; Transcription factor DP

    11. XM_063265215.1 → XP_063121285.1  transcription factor Dp-2 isoform X2

    12. XM_039081183.2 → XP_038937111.1  transcription factor Dp-2 isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZNQ2
      Conserved Domains (3) summary
      cd14458
      Location:117 → 163
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:32 → 112
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:119 → 257
      DP; Transcription factor DP

    13. XM_063265220.1 → XP_063121290.1  transcription factor Dp-2 isoform X9

      UniProtKB/TrEMBL
      A0A8I6A268

    14. XM_063265222.1 → XP_063121292.1  transcription factor Dp-2 isoform X11

    15. XM_039081180.1 → XP_038937108.1  transcription factor Dp-2 isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZNQ2, A0A8I6A8L4
      Related
      ENSRNOP00000079538.2, ENSRNOT00000107228.2
      Conserved Domains (3) summary
      cd14458
      Location:153 → 199
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:68 → 148
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:155 → 293
      DP; Transcription factor DP

    16. XM_063265217.1 → XP_063121287.1  transcription factor Dp-2 isoform X6

      Related
      ENSRNOP00000105970.1, ENSRNOT00000133684.1

    17. XM_006243561.5 → XP_006243623.1  transcription factor Dp-2 isoform X4

      Related
      ENSRNOP00000015014.7, ENSRNOT00000015015.8
      Conserved Domains (3) summary
      cd14458
      Location:197 → 243
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:112 → 192
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:199 → 338
      DP; Transcription factor DP

    18. XM_063265218.1 → XP_063121288.1  transcription factor Dp-2 isoform X7

    19. XM_063265219.1 → XP_063121289.1  transcription factor Dp-2 isoform X8

    20. XM_039081186.2 → XP_038937114.1  transcription factor Dp-2 isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZNQ2
      Conserved Domains (3) summary
      cd14458
      Location:117 → 163
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:32 → 112
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:119 → 257
      DP; Transcription factor DP

    21. XM_039081185.2 → XP_038937113.1  transcription factor Dp-2 isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZNQ2
      Conserved Domains (3) summary
      cd14458
      Location:117 → 163
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:32 → 112
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:119 → 257
      DP; Transcription factor DP

    22. XM_039081187.2 → XP_038937115.1  transcription factor Dp-2 isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZNQ2
      Conserved Domains (3) summary
      cd14458
      Location:117 → 163
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:32 → 112
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:119 → 257
      DP; Transcription factor DP

    23. XM_063265221.1 → XP_063121291.1  transcription factor Dp-2 isoform X10

      UniProtKB/TrEMBL
      A0A8I6A8L4

    24. XM_039081184.2 → XP_038937112.1  transcription factor Dp-2 isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZNQ2
      Conserved Domains (3) summary
      cd14458
      Location:117 → 163
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:32 → 112
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:119 → 257
      DP; Transcription factor DP

    25. XM_039081179.1 → XP_038937107.1  transcription factor Dp-2 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZNQ2, A0A8I6A268
      Conserved Domains (3) summary
      cd14458
      Location:154 → 200
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:69 → 149
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:156 → 294
      DP; Transcription factor DP
    Nucleotide Protein Strain
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