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    Mrpl13 mitochondrial ribosomal protein L13 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299938, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mrpl13provided by RGD
    Official Full Name
    mitochondrial ribosomal protein L13provided by RGD
    Primary source
    RGD:1359587
    See related
    Ensembl:ENSRNOG00000004401 AllianceGenome:RGD:1359587
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable mRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in negative regulation of translation. Predicted to be located in mitochondrial ribosome. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in ribosome. Orthologous to human MRPL13 (mitochondrial ribosomal protein L13). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 503.7), Muscle (RPKM 269.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mrpl13 in Genome Data Viewer
    Location:
    7q32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (88841265..88862821, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (86951541..86973147, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (95288400..95309997, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31, pseudogene 5 Neighboring gene collagen type XIV alpha 1 chain Neighboring gene eukaryotic translation initiation factor 1, pseudogene 1 Neighboring gene uncharacterized LOC120093658 Neighboring gene MDM2 binding protein Neighboring gene syntrophin, beta 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome. Cámara Y, et al. Cell Metab, 2011 May 4. PMID 21531335
    2. Properties of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L and its interactions with mammalian mitochondrial ribosomes. Haque ME, et al. J Biol Chem, 2010 Sep 3. PMID 20601428, Free PMC Article
    3. Initial steps in RNA processing and ribosome assembly occur at mitochondrial DNA nucleoids. Bogenhagen DF, et al. Cell Metab, 2014 Apr 1. PMID 24703694
    4. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. Kenmochi N, et al. Genomics, 2001 Sep. PMID 11543634
    5. Structures of the human mitochondrial ribosome in native states of assembly. Brown A, et al. Nat Struct Mol Biol, 2017 Oct. PMID 28892042, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105961

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein uL13m
    Names
    39S ribosomal protein L13, mitochondrial
    NP_001006986.1
    XP_006241713.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006985.1 → NP_001006986.1  large ribosomal subunit protein uL13m

      See identical proteins and their annotated locations for NP_001006986.1

      Status: PROVISIONAL

      Source sequence(s)
      BC084710
      UniProtKB/TrEMBL
      F7FDQ1, Q5XFW4
      Related
      ENSRNOP00000005815.3, ENSRNOT00000005815.7
      Conserved Domains (1) summary
      pfam00572
      Location:17 → 140
      Ribosomal_L13; Ribosomal protein L13

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      88841265..88862821 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241651.3 → XP_006241713.1  large ribosomal subunit protein uL13m isoform X1

      See identical proteins and their annotated locations for XP_006241713.1

      UniProtKB/TrEMBL
      A6HRH4
      Conserved Domains (1) summary
      pfam00572
      Location:1 → 124
      Ribosomal_L13; Ribosomal protein L13
    Nucleotide Protein Strain
    Heading Accession and Version

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