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    Cdc34 cell division cycle 34, ubiqiutin conjugating enzyme [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299602, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cdc34provided by RGD
    Official Full Name
    cell division cycle 34, ubiqiutin conjugating enzymeprovided by RGD
    Primary source
    RGD:1305411
    See related
    EnsemblRapid:ENSRNOG00000060530 AllianceGenome:RGD:1305411
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity. Involved in positive regulation of inclusion body assembly; positive regulation of neuron apoptotic process; and response to growth factor. Predicted to be located in cytosol and nuclear speck. Orthologous to human CDC34 (cell division cycle 34, ubiqiutin conjugating enzyme). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 539.4), Testes (RPKM 307.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdc34 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10668209..10674206, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (10017588..10023586, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12899957..12905339, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479816 Neighboring gene basigin Neighboring gene granzyme M Neighboring gene tubulin polyglutamylase complex subunit 1 Neighboring gene mucosal vascular addressin cell adhesion molecule 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Differential regulation of components of the ubiquitin-proteasome pathway during lens cell differentiation. Guo W, et al. Invest Ophthalmol Vis Sci, 2004 Apr. PMID 15037588, Free PMC Article
    2. Proteasomal inhibition-induced inclusion formation and death in cortical neurons require transcription and ubiquitination. Rideout HJ, et al. Mol Cell Neurosci, 2002 Oct. PMID 12401444
    3. Cloning and characterization of a novel NK cell-specific serine protease gene and its functional 5'-flanking sequences. Smyth MJ, et al. Immunogenetics, 1995. PMID 7607701
    4. Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis. Pati D, et al. Mol Cell Biol, 1999 Jul. PMID 10373550, Free PMC Article
    5. Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate. Wu K, et al. Mol Cell, 2010 Mar 26. PMID 20347421, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116225

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to interferon-beta ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of inclusion body assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to growth factor IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme E2 R1
    Names
    cell division cycle 34 homolog
    serine protease
    ubiquitin-conjugating enzyme Cdc34
    NP_001013121.2
    XP_038934562.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013103.2 → NP_001013121.2  ubiquitin-conjugating enzyme E2 R1

      See identical proteins and their annotated locations for NP_001013121.2

      Status: VALIDATED

      Source sequence(s)
      BG375350, CB611861
      UniProtKB/TrEMBL
      A6K8Z0, D4A453
      Related
      ENSRNOP00000095465.1, ENSRNOT00000116036.2
      Conserved Domains (1) summary
      cd00195
      Location:11 → 162
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      10668209..10674206 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078634.2 → XP_038934562.1  ubiquitin-conjugating enzyme E2 R1 isoform X1

      UniProtKB/TrEMBL
      A6K8Y9
      Conserved Domains (1) summary
      cd00195
      Location:11 → 162
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Chemical Information
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