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    IL19 interleukin 19 [ Homo sapiens (human) ]

    Gene ID: 29949, updated on 28-Oct-2024

    Summary

    Official Symbol
    IL19provided by HGNC
    Official Full Name
    interleukin 19provided by HGNC
    Primary source
    HGNC:HGNC:5990
    See related
    Ensembl:ENSG00000142224 MIM:605687; AllianceGenome:HGNC:5990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MDA1; NG.1; ZMDA1; IL-10C
    Summary
    The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See IL19 in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (206770773..206842981)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (206034974..206107261)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (206944118..207016326)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904496 Neighboring gene uncharacterized LOC124904495 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1761 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1762 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1763 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1764 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:206860855-206861416 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:206861417-206861978 Neighboring gene MAPK activated protein kinase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2412 Neighboring gene Sharpr-MPRA regulatory region 3087 Neighboring gene ribosomal protein S14 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:206895773-206896486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2413 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2414 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1765 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1766 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2415 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2416 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2417 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:206937123-206937321 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2418 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2419 Neighboring gene CRISPRi-FlowFISH-validated IL10 regulatory element GRCh37_chr1:206945468-206946089 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2420 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2421 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2422 Neighboring gene interleukin 10 Neighboring gene CRISPRi-FlowFISH-validated IL10 regulatory elements GRCh37_chr1:206966528-206967028 and GRCh37_chr1:206966531-206967031 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2423 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2424 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2425 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1767 Neighboring gene uncharacterized LOC105372878 Neighboring gene uncharacterized LOC105372879 Neighboring gene interleukin 20 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:207063449-207064648

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
    EBI GWAS Catalog
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat IL-19 is upregulated in human epithelial cells by HIV-1 Tat treatment PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    interleukin-19
    Names
    melanoma differentiation associated protein-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001369605.1NP_001356534.1  interleukin-19 precursor

      Status: REVIEWED

      Source sequence(s)
      AF453946, AL513315, AY040367, CA309757
      Consensus CDS
      CCDS1469.1
      UniProtKB/Swiss-Prot
      B6VEV9, Q5VUT3, Q96QR4, Q9NUA0, Q9UHD0
      Related
      ENSP00000343000.3, ENST00000340758.7
      Conserved Domains (1) summary
      cl02501
      Location:21167
      IL10; Interleukin 10
    2. NM_001393490.1NP_001380419.1  interleukin-19 precursor

      Status: REVIEWED

      Source sequence(s)
      AL513315
      Consensus CDS
      CCDS1469.1
      UniProtKB/Swiss-Prot
      B6VEV9, Q5VUT3, Q96QR4, Q9NUA0, Q9UHD0
      Related
      ENSP00000499487.2, ENST00000656872.2
      Conserved Domains (1) summary
      cl02501
      Location:21167
      IL10; Interleukin 10
    3. NM_001393491.1NP_001380420.1  interleukin-19 precursor

      Status: REVIEWED

      Source sequence(s)
      AL513315
      Consensus CDS
      CCDS1469.1
      UniProtKB/Swiss-Prot
      B6VEV9, Q5VUT3, Q96QR4, Q9NUA0, Q9UHD0
      Conserved Domains (1) summary
      cl02501
      Location:21167
      IL10; Interleukin 10
    4. NM_013371.5NP_037503.2  interleukin-19 precursor

      See identical proteins and their annotated locations for NP_037503.2

      Status: REVIEWED

      Source sequence(s)
      AL513315
      Consensus CDS
      CCDS1469.1
      UniProtKB/Swiss-Prot
      B6VEV9, Q5VUT3, Q96QR4, Q9NUA0, Q9UHD0
      Related
      ENSP00000270218.6, ENST00000270218.10
      Conserved Domains (1) summary
      cl02501
      Location:21167
      IL10; Interleukin 10
    5. NM_153758.5NP_715639.2  interleukin-19 precursor

      Status: REVIEWED

      Source sequence(s)
      AL513315
      Consensus CDS
      CCDS1469.1
      UniProtKB/Swiss-Prot
      B6VEV9, Q5VUT3, Q96QR4, Q9NUA0, Q9UHD0
      Related
      ENSP00000499459.2, ENST00000659997.3
      Conserved Domains (1) summary
      cl02501
      Location:21167
      IL10; Interleukin 10

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      206770773..206842981
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011509450.3XP_011507752.1  interleukin-19 isoform X1

      See identical proteins and their annotated locations for XP_011507752.1

      UniProtKB/Swiss-Prot
      Q9UHD0

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      206034974..206107261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336198.1XP_054192173.1  interleukin-19 isoform X1