U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Dlst dihydrolipoamide S-succinyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299201, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Dlstprovided by RGD
    Official Full Name
    dihydrolipoamide S-succinyltransferaseprovided by RGD
    Primary source
    RGD:1359615
    See related
    EnsemblRapid:ENSRNOG00000005061 AllianceGenome:RGD:1359615
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables dihydrolipoyllysine-residue succinyltransferase activity; heat shock protein binding activity; and protein-folding chaperone binding activity. Involved in 2-oxoglutarate metabolic process and NADH metabolic process. Part of oxoglutarate dehydrogenase complex. Human ortholog(s) of this gene implicated in Alzheimer's disease and paraganglioma. Orthologous to human DLST (dihydrolipoamide S-succinyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 866.4), Kidney (RPKM 659.9) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Dlst in Genome Data Viewer
    Location:
    6q31
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (110489576..110512841)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (104758511..104783296)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (108936534..108961322)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene YLP motif containing 1 Neighboring gene small nucleolar RNA U13 Neighboring gene U4 spliceosomal RNA Neighboring gene prospero homeobox 2 Neighboring gene ribosomal protein S6 kinase-like 1 Neighboring gene placental growth factor

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Isolation and sequence analysis of the rat dihydrolipoamide succinyltransferase gene. Nakano K, et al. DNA Seq, 2002 Dec. PMID 12652908
    2. A novel protein found in the I bands of myofibrils is produced by alternative splicing of the DLST gene. Matuda S, et al. Biochim Biophys Acta, 2010 Jan. PMID 19819302
    3. Recurrent Germline DLST Mutations in Individuals with Multiple Pheochromocytomas and Paragangliomas. Remacha L, et al. Am J Hum Genet, 2019 Apr 4. PMID 30929736, Free PMC Article
    4. Purification and molecular cloning of succinyltransferase of the rat alpha-ketoglutarate dehydrogenase complex. Absence of a sequence motif of the putative E3 and/or E1 binding site. Nakano K, et al. J Biol Chem, 1991 Oct 5. PMID 1918017
    5. A polypeptide derived from mitochondrial dihydrolipoamide succinyltransferase is located on the plasma membrane in skeletal muscle. Matuda S, et al. Biochem Biophys Res Commun, 1997 Dec 8. PMID 9405249

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that the DLST gene produces two different proteins with quite different functions via alternative splicing.
      Title: A novel protein found in the I bands of myofibrils is produced by alternative splicing of the DLST gene.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC95077

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dihydrolipoyllysine-residue succinyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dihydrolipoyllysine-residue succinyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dihydrolipoyllysine-residue succinyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dihydrolipoyllysine-residue succinyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heat shock protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-folding chaperone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 2-oxoglutarate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in 2-oxoglutarate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-lysine catabolic process to acetyl-CoA via saccharopine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NADH metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in succinyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in succinyl-CoA metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tricarboxylic acid cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of oxoadipate dehydrogenase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of oxoadipate dehydrogenase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of oxoglutarate dehydrogenase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of oxoglutarate dehydrogenase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of oxoglutarate dehydrogenase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
    Names
    2-oxoglutarate dehydrogenase complex component E2
    E2
    E2K
    OGDC-E2
    dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
    dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex
    NP_001006982.2
    XP_006240368.1
    XP_008762978.1
    XP_038967973.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006981.2 → NP_001006982.2  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

      See identical proteins and their annotated locations for NP_001006982.2

      Status: VALIDATED

      Source sequence(s)
      BC083858, CB807447, CK355938, CK845707
      UniProtKB/Swiss-Prot
      Q01205, Q5XI35
      UniProtKB/TrEMBL
      A6JE02, G3V6P2
      Related
      ENSRNOP00000007298.4, ENSRNOT00000007298.6
      Conserved Domains (3) summary
      cd06849
      Location:72 → 144
      lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
      TIGR01347
      Location:72 → 454
      sucB; 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component)
      pfam00198
      Location:239 → 452
      2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      110489576..110512841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240306.3 → XP_006240368.1  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q8CJG5
      Related
      ENSRNOP00000109609.1, ENSRNOT00000142994.1
      Conserved Domains (3) summary
      cd06849
      Location:97 → 169
      lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
      TIGR01347
      Location:97 → 479
      sucB; 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component)
      pfam00198
      Location:264 → 477
      2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)

    2. XM_008764756.3 → XP_008762978.1  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform X3

      UniProtKB/TrEMBL
      D0VYQ0
      Conserved Domains (1) summary
      pfam00198
      Location:55 → 268
      2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)

    3. XM_039112045.2 → XP_038967973.1  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform X2

      UniProtKB/Swiss-Prot
      Q01205, Q5XI35
      UniProtKB/TrEMBL
      Q8CJG5
      Conserved Domains (1) summary
      TIGR01347
      Location:25 → 407
      sucB; 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01205.2 GenPept UniProtKB/Swiss-Prot:Q01205

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous