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    Atad3a ATPase family, AAA domain containing 3A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298682, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Atad3aprovided by RGD
    Official Full Name
    ATPase family, AAA domain containing 3Aprovided by RGD
    Primary source
    RGD:1305964
    See related
    EnsemblRapid:ENSRNOG00000018118 AllianceGenome:RGD:1305964
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Atad3
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including antiviral innate immune response; mitochondrion organization; and regulation of cell growth. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in Harel-Yoon syndrome and neonatal lethal pontocerebellar hypoplasia, hypotonia, and respiratory insufficiency syndrome. Orthologous to several human genes including ATAD3A (ATPase family AAA domain containing 3A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 125.0), Adrenal (RPKM 122.4) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Atad3a in Genome Data Viewer
    Location:
    5q36
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171632545..171652725, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (166350302..166370492, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (173189590..173209809, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene fibronectin type III domain containing 10 Neighboring gene SSU72 homolog, RNA polymerase II CTD phosphatase Neighboring gene U6 spliceosomal RNA Neighboring gene transmembrane protein 240 Neighboring gene ATPase family, AAA domain containing 3A, opposite strand Neighboring gene von Willebrand factor A domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ATPase family AAA domain-containing 3A is a novel anti-apoptotic factor in lung adenocarcinoma cells. Fang HY, et al. J Cell Sci, 2010 Apr 1. PMID 20332122
    2. Mitochondria-associated membrane formation in hormone-stimulated Leydig cell steroidogenesis: role of ATAD3. Issop L, et al. Endocrinology, 2015 Jan. PMID 25375035
    3. Atad3 function is essential for early post-implantation development in the mouse. Goller T, et al. PLoS One, 2013. PMID 23372768, Free PMC Article
    4. ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects. Zhao Y, et al. Nat Commun, 2019 Mar 26. PMID 30914652, Free PMC Article
    5. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124646

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of HRI-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of HRI-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in antiviral innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial nucleoid IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ATPase family AAA domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034922.1 → NP_001030094.1  ATPase family AAA domain-containing protein 3

      See identical proteins and their annotated locations for NP_001030094.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105762
      UniProtKB/Swiss-Prot
      Q3KRE0
      UniProtKB/TrEMBL
      A0A8I6AD85, A6IUR9
      Related
      ENSRNOP00000046842.3, ENSRNOT00000045053.5
      Conserved Domains (2) summary
      pfam12037
      Location:27 → 285
      DUF3523; Domain of unknown function (DUF3523)
      cd19512
      Location:323 → 472
      RecA-like_ATAD3-like; ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      171632545..171652725 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001837838.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3KRE0.1 GenPept UniProtKB/Swiss-Prot:Q3KRE0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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