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    Fhl5 four and a half LIM domains 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297954, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Fhl5provided by RGD
    Official Full Name
    four and a half LIM domains 5provided by RGD
    Primary source
    RGD:1307056
    See related
    EnsemblRapid:ENSRNOG00000007680 AllianceGenome:RGD:1307056
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in Z disc and nucleus. Orthologous to human FHL5 (four and a half LIM domains 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 375.6) and Muscle (RPKM 27.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fhl5 in Genome Data Viewer
    Location:
    5q21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (43704493..43753356, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (38907941..38956759, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (39564241..39611273, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 63 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene Ufm1-specific ligase 1 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CBP-independent activation of CREM and CREB by the LIM-only protein ACT. Fimia GM, et al. Nature, 1999 Mar 11. PMID 10086359
    2. Sperm associated antigen 8 (SPAG8), a novel regulator of activator of CREM in testis during spermatogenesis. Wu H, et al. FEBS Lett, 2010 Jul 2. PMID 20488182
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    four and a half LIM domains protein 5
    Names
    FHL-5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013088.1 → NP_001013106.1  four and a half LIM domains protein 5

      See identical proteins and their annotated locations for NP_001013106.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079327
      UniProtKB/Swiss-Prot
      Q6AXT1
      UniProtKB/TrEMBL
      A0A8I5ZQD5
      Related
      ENSRNOP00000047630.4, ENSRNOT00000046595.4
      Conserved Domains (4) summary
      cd09343
      Location:37 → 95
      LIM1_FHL; The first LIM domain of Four and a half LIM domains protein (FHL)
      cd09347
      Location:222 → 277
      LIM4_FHL; The fourth LIM domain of Four and a half LIM domains protein (FHL)
      cd09428
      Location:102 → 155
      LIM2_FHL5; The second LIM domain of Four and a half LIM domains protein 5 (FHL5)
      cl02475
      Location:163 → 214
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      43704493..43753356 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109426.2 → XP_038965354.1  four and a half LIM domains protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q6AXT1
      UniProtKB/TrEMBL
      A0A8I5ZQD5
      Conserved Domains (4) summary
      cd09343
      Location:37 → 95
      LIM1_FHL; The first LIM domain of Four and a half LIM domains protein (FHL)
      cd09347
      Location:222 → 277
      LIM4_FHL; The fourth LIM domain of Four and a half LIM domains protein (FHL)
      cd09428
      Location:102 → 155
      LIM2_FHL5; The second LIM domain of Four and a half LIM domains protein 5 (FHL5)
      cl02475
      Location:163 → 214
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    2. XM_017593233.3 → XP_017448722.1  four and a half LIM domains protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q6AXT1
      UniProtKB/TrEMBL
      A0A8I5ZQD5
      Conserved Domains (4) summary
      cd09343
      Location:37 → 95
      LIM1_FHL; The first LIM domain of Four and a half LIM domains protein (FHL)
      cd09347
      Location:222 → 277
      LIM4_FHL; The fourth LIM domain of Four and a half LIM domains protein (FHL)
      cd09428
      Location:102 → 155
      LIM2_FHL5; The second LIM domain of Four and a half LIM domains protein 5 (FHL5)
      cl02475
      Location:163 → 214
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    3. XM_008763595.4 → XP_008761817.2  four and a half LIM domains protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q6AXT1
      UniProtKB/TrEMBL
      A0A8I5ZQD5
      Conserved Domains (4) summary
      cd09343
      Location:37 → 95
      LIM1_FHL; The first LIM domain of Four and a half LIM domains protein (FHL)
      cd09347
      Location:222 → 277
      LIM4_FHL; The fourth LIM domain of Four and a half LIM domains protein (FHL)
      cd09428
      Location:102 → 155
      LIM2_FHL5; The second LIM domain of Four and a half LIM domains protein 5 (FHL5)
      cl02475
      Location:163 → 214
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    4. XM_063287299.1 → XP_063143369.1  four and a half LIM domains protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q6AXT1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AXT1.1 GenPept UniProtKB/Swiss-Prot:Q6AXT1

    Gene LinkOut

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