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    Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29713, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Kcnj5provided by RGD
    Official Full Name
    potassium inwardly-rectifying channel, subfamily J, member 5provided by RGD
    Primary source
    RGD:61971
    See related
    EnsemblRapid:ENSRNOG00000033796 AllianceGenome:RGD:61971
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable inward rectifier potassium channel activity and voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization. Predicted to be involved in cardiac conduction; potassium ion import across plasma membrane; and regulation of monoatomic ion transmembrane transport. Located in T-tubule and external side of plasma membrane. Human ortholog(s) of this gene implicated in atrial fibrillation; long QT syndrome 13; and primary hyperaldosteronism. Orthologous to human KCNJ5 (potassium inwardly rectifying channel subfamily J member 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 183.1), Lung (RPKM 29.3) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kcnj5 in Genome Data Viewer
    Location:
    8q21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (38981598..39011197, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (30724923..30753083, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (33435493..33463410, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480155 Neighboring gene Rho GTPase activating protein 32 Neighboring gene ribosomal protein L35 like 2 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 1 Neighboring gene Fli-1 proto-oncogene, ETS transcription factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Effect of small interference RNA on the acetylcholine-sensitive potassium channel in H9c2 cells. He F, et al. Ann Clin Lab Sci, 2015 Winter. PMID 25696012
    2. Constitutively Active Acetylcholine-Dependent Potassium Current Increases Atrial Defibrillation Threshold by Favoring Post-Shock Re-Initiation. Bingen BO, et al. Sci Rep, 2015 Oct 21. PMID 26487066, Free PMC Article
    3. G-protein-gated inwardly rectifying K+ channel 4 (GIRK4) immunoreactivity in chemically defined neurons of the hypothalamic arcuate nucleus that control body weight. Kloukina V, et al. J Chem Neuroanat, 2012 May. PMID 22465809
    4. Alterations in potassium channel gene expression in atria of patients with persistent and paroxysmal atrial fibrillation: differential regulation of protein and mRNA levels for K+ channels. Brundel BJ, et al. J Am Coll Cardiol, 2001 Mar 1. PMID 11693772
    5. The KATP channel is a molecular sensor of atrophy in skeletal muscle. Tricarico D, et al. J Physiol, 2010 Mar 1. PMID 20064856, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Blocking IK,ACh-c by tertiapin significantly decreased DFT, which correlated with a significant increase in wavelength during reentry. Genetic knockdown experiments with Kcnj5-specific shRNA to modulate IK,ACh-c, yielded similar results
      Title: Constitutively Active Acetylcholine-Dependent Potassium Current Increases Atrial Defibrillation Threshold by Favoring Post-Shock Re-Initiation.
    2. The KCNJ5 gene and Kir3.4 protein were measured, and acetylcholine-sensitive potassium channel currents were recorded by patch-clamp.
      Title: Effect of small interference RNA on the acetylcholine-sensitive potassium channel in H9c2 cells.
    3. localized in intercalated discs in rat ventricle, whereas it was expressed in intercalated discs and outer sarcolemmas in rat atrium
      Title: G-protein-coupled inward rectifier potassium current contributes to ventricular repolarization.
    4. the GIRK4 channel protein plays a role in regulating membrane excitability in chemically defined neurons of the arcuate nucleus that control body weight
      Title: G-protein-gated inwardly rectifying K+ channel 4 (GIRK4) immunoreactivity in chemically defined neurons of the hypothalamic arcuate nucleus that control body weight.
    5. Estradiol regulates dopamine-activataed GIRK channel activity in pituitary lactotrophs, regulating prolactin release during the estrous cycle.
      Title: Estrogen regulation of the dopamine-activated GIRK channel in pituitary lactotrophs: implications for regulation of prolactin release during the estrous cycle.
    6. All these findings suggest a new role for the K(ATP) channel as a molecular sensor of atrophy.
      Title: The KATP channel is a molecular sensor of atrophy in skeletal muscle.
    7. hydrogen sulfide-induced increase in I(K,ATP) on both atrial and ventricular myocytes was concentration dependent
      Title: Hydrogen sulfide opens the KATP channel on rat atrial and ventricular myocytes.
    8. Galpha(q) interacted with N termini of Kir3.1, Kir3.2, and Kir3.4. However, Galpha(q) did not interact with the C terminus of any Kir3
      Title: Interaction of Galphaq and Kir3, G protein-coupled inwardly rectifying potassium channels.
    9. The point mutation L337R in the GIRK4 C terminus decreased the association between the N and C termini.
      Title: Mutation of critical GIRK subunit residues disrupts N- and C-termini association and channel function.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93525

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G-protein activated inward rectifier potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to inward rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in membrane repolarization during atrial cardiac muscle cell action potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane repolarization during atrial cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in potassium ion transmembrane transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of heart rate by cardiac conduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of heart rate by cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of I(KACh) inward rectifier potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in T-tubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    G protein-activated inward rectifier potassium channel 4
    Names
    CIR
    GIRK-4
    GIRK4
    KATP-1
    cardiac inward rectifier
    heart KATP channel
    inward rectifier K(+) channel Kir3.4
    potassium channel, inwardly rectifying subfamily J member 5
    potassium voltage-gated channel subfamily J member 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017297.2 → NP_058993.1  G protein-activated inward rectifier potassium channel 4

      See identical proteins and their annotated locations for NP_058993.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087022
      UniProtKB/Swiss-Prot
      P48548
      Related
      ENSRNOP00000048134.5, ENSRNOT00000041038.7
      Conserved Domains (2) summary
      pfam01007
      Location:54 → 193
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:200 → 371
      IRK_C; Inward rectifier potassium channel C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      38981598..39011197 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080975.2 → XP_038936903.1  G protein-activated inward rectifier potassium channel 4 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G4T8
      Related
      ENSRNOP00000079101.1, ENSRNOT00000110676.2
      Conserved Domains (2) summary
      pfam01007
      Location:73 → 212
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:219 → 390
      IRK_C; Inward rectifier potassium channel C-terminal domain

    2. XM_039080976.2 → XP_038936904.1  G protein-activated inward rectifier potassium channel 4 isoform X3

      UniProtKB/Swiss-Prot
      P48548
      Conserved Domains (2) summary
      pfam01007
      Location:54 → 193
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:200 → 371
      IRK_C; Inward rectifier potassium channel C-terminal domain

    3. XM_039080977.2 → XP_038936905.1  G protein-activated inward rectifier potassium channel 4 isoform X3

      UniProtKB/Swiss-Prot
      P48548
      Conserved Domains (2) summary
      pfam01007
      Location:54 → 193
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:200 → 371
      IRK_C; Inward rectifier potassium channel C-terminal domain

    4. XM_063265036.1 → XP_063121106.1  G protein-activated inward rectifier potassium channel 4 isoform X3

      UniProtKB/Swiss-Prot
      P48548

    5. XM_063265035.1 → XP_063121105.1  G protein-activated inward rectifier potassium channel 4 isoform X1

      Related
      ENSRNOP00000099016.1, ENSRNOT00000159264.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48548.2 GenPept UniProtKB/Swiss-Prot:P48548

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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