Gria3 glutamate ionotropic receptor AMPA type subunit 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gria3provided by RGD
Official Full Name: glutamate ionotropic receptor AMPA type subunit 3provided by RGD
Primary source: RGD:70958
See related: EnsemblRapid:ENSRNOG00000007682 AllianceGenome:RGD:70958
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: GLUR3; GluA3; GluR-3; GluR-C; GluR-K3
Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]
Expression: Biased expression in Adrenal (RPKM 265.0), Brain (RPKM 192.4) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq35

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (125103975..125369690)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (120238515..120504106)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (127561843..127829763)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study shows that oxygen and glucose deprivation (OGD) causes endocytosis, lysosomal targeting and consequent degradation of GluA2- and GluA3-containing AMPARs, and that PICK1 is required for both OGD-induced GluA2 endocytosis and lysosomal sorting. GluA1-containing AMPARs resist OGD-induced endocytosis and PICK1 binding to the endocytic adaptor AP2 is enhanced by OGD in hippocampal, but not cortical neurons.
Title: Endocytosis and lysosomal degradation of GluA2/3 AMPARs in response to oxygen/glucose deprivation in hippocampal but not cortical neurons.
results lead to a model of cooperative activation of mGluRs that provides a framework for understanding how class C GPCRs couple extracellular binding to dimer reorganization and G protein activation.
Title: Mechanism of Assembly and Cooperativity of Homomeric and Heteromeric Metabotropic Glutamate Receptors.
This study showed that GluA3 is uniformly distributed along the synapse, and seldom extends beyond its lateral border in hippocamoys.
Title: The organization of AMPA receptor subunits at the postsynaptic membrane.
The results of this study support the local translation of GluA1-4 mRNAs in dendrites of hippocampal pyramidal cells and CA1 interneurons but not in granule cells of the dentate gyrus.
Title: Differential dendritic targeting of AMPA receptor subunit mRNAs in adult rat hippocampal principal neurons and interneurons.
A decrease in GluA1 and increases in GluA3 subunit and TARP expression at the end of the third postnatal week provide a molecular explanation for the increase in AMPAR response duration and reduced efficacy of AMPAR modulators with increasing age.
Title: Developmental changes in structural and functional properties of hippocampal AMPARs parallels the emergence of deliberative spatial navigation in juvenile rats.
Here we examine whether hypoxia in the developing retina would cause activation of the AMPA GluRs and increase in Ca(2+) influx into retinal ganglion cells (RGCs) that might ultimately lead to their death.
Title: Hypoxia-induced retinal ganglion cell damage through activation of AMPA receptors and the neuroprotective effects of DNQX.
GluR2/3 is translocated into the intracellular pool following brain ischemia-reperfusion.
Title: Phosphorylation and assembly of glutamate receptors after brain ischemia.
Under 21 days of immobilization stress, expression of GluR2/3 increased in the hippocampal CA1 region but deacreased in the amygdala. Xiaoyaosan could reverse gene expression.
Title: [Expression of AMPA receptors and related protein in immobilization stressed rats and effect of Xiaoyaosan].
Bushy cells and fusiform cells upregulated GluA3 and downregulated GlyRalpha1 expression following 7 days of monaural conductive hearing loss
Title: Monaural conductive hearing loss alters the expression of the GluA3 AMPA and glycine receptor α1 subunits in bushy and fusiform cells of the cochlear nucleus.
Similar to clozapine, JL 13 does not alter levels of NMDA and AMPA receptors in hippocampus and entorhinal cortex.
Title: Long-term effects of JL 13, a potential atypical antipsychotic, on ionotropic glutamate receptors.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

DXGot55 (e-PCR)
- UniSTS:115224

Gria3 (e-PCR), detects polymorphism
- UniSTS:496045

RH143176 (e-PCR)
- UniSTS:232423

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables AMPA glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables AMPA glutamate receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables AMPA glutamate receptor activity	IEA Inferred from Electronic Annotation more info
enables AMPA glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables amyloid-beta binding	IPI Inferred from Physical Interaction more info	PubMed
enables glutamate-gated calcium ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate-gated receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate-gated receptor activity	ISO Inferred from Sequence Orthology more info
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in ionotropic glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
involved_in long-term synaptic potentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in protein heterotetramerization	IEA Inferred from Electronic Annotation more info
involved_in protein heterotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein heterotetramerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homotetramerization	IEA Inferred from Electronic Annotation more info
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of receptor recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to fungicide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lithium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of AMPA glutamate receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of AMPA glutamate receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of AMPA glutamate receptor complex	IEA Inferred from Electronic Annotation more info
part_of AMPA glutamate receptor complex	ISO Inferred from Sequence Orthology more info
located_in asymmetric synapse	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic shaft	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
part_of ionotropic glutamate receptor complex	TAS Traceable Author Statement more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in parallel fiber to Purkinje cell synapse	IEA Inferred from Electronic Annotation more info
is_active_in parallel fiber to Purkinje cell synapse	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed
located_in synaptic cleft	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glutamate receptor 3

Names: AMPA-selective glutamate receptor 3; glutamate receptor, ionotrophic, AMPA 3; glutamate receptor, ionotropic, AMPA 3; glutamate receptor, ionotropic, AMPA3 (alpha 3)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001112742.1 → NP_001106213.1 glutamate receptor 3 isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate internal coding exon compared to transcript variant 1, and encodes an isoform (2, also known as flop isoform) that is the same length, but with a few amino acid differences from isoform 1. RNA editing (AGA->GGA) changes Arg769Gly.

Source sequence(s)

BC091324, BF559208, BQ205510, CB713194, DV723256, EV762496, JAXUCZ010000021, M85036, X54656

UniProtKB/Swiss-Prot

P19492

Conserved Domains (4) summary

cd06387
Location:29 → 400

PBP1_iGluR_AMPA_GluR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor

cd13715
Location:416 → 799

PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:548 → 829

Lig_chan; Ligand-gated ion channel

pfam01094
Location:40 → 383

ANF_receptor; Receptor family ligand binding region
NM_032990.2 → NP_116785.2 glutamate receptor 3 isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform 1 (also known as flip isoform). RNA editing (AGA->GGA) changes Arg769Gly.

Source sequence(s)

BC091324, BF559208, BQ205510, CB713194, DV723256, EV762496, JAXUCZ010000021, X54656

UniProtKB/Swiss-Prot

P19492

Related

ENSRNOP00000031170.7, ENSRNOT00000029031.9

Conserved Domains (4) summary

cd06387
Location:29 → 400

PBP1_iGluR_AMPA_GluR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor

cd13715
Location:416 → 799

PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:548 → 829

Lig_chan; Ligand-gated ion channel

pfam01094
Location:40 → 383

ANF_receptor; Receptor family ligand binding region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

125103975..125369690

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017601951.3 → XP_017457440.1 glutamate receptor 3 isoform X2

UniProtKB/Swiss-Prot

P19492

UniProtKB/TrEMBL

A6JML6, G3V8Y9

Related

ENSRNOP00000098984.1, ENSRNOT00000169900.1

Conserved Domains (4) summary

cd06387
Location:29 → 400

PBP1_iGluR_AMPA_GluR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor

cd13715
Location:416 → 799

PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:548 → 829

Lig_chan; Ligand-gated ion channel

pfam01094
Location:40 → 383

ANF_receptor; Receptor family ligand binding region
XM_006257501.5 → XP_006257563.1 glutamate receptor 3 isoform X1

See identical proteins and their annotated locations for XP_006257563.1

UniProtKB/Swiss-Prot

P19492

UniProtKB/TrEMBL

A6JML7, G3V6Z5

Related

ENSRNOP00000010367.6, ENSRNOT00000010367.8

Conserved Domains (4) summary

cd06387
Location:29 → 400

PBP1_iGluR_AMPA_GluR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor

cd13715
Location:416 → 799

PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:548 → 829

Lig_chan; Ligand-gated ion channel

pfam01094
Location:40 → 383

ANF_receptor; Receptor family ligand binding region
XM_006257496.5 → XP_006257558.1 glutamate receptor 3 isoform X1

See identical proteins and their annotated locations for XP_006257558.1

UniProtKB/Swiss-Prot

P19492

UniProtKB/TrEMBL

A6JML7, G3V6Z5

Conserved Domains (4) summary

cd06387
Location:29 → 400

PBP1_iGluR_AMPA_GluR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor

cd13715
Location:416 → 799

PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:548 → 829

Lig_chan; Ligand-gated ion channel

pfam01094
Location:40 → 383

ANF_receptor; Receptor family ligand binding region
XM_017601950.3 → XP_017457439.1 glutamate receptor 3 isoform X1

UniProtKB/Swiss-Prot

P19492

UniProtKB/TrEMBL

A6JML7, G3V6Z5

Conserved Domains (4) summary

cd06387
Location:29 → 400

PBP1_iGluR_AMPA_GluR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor

cd13715
Location:416 → 799

PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:548 → 829

Lig_chan; Ligand-gated ion channel

pfam01094
Location:40 → 383

ANF_receptor; Receptor family ligand binding region