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    Tgm6 transglutaminase 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296152, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Tgm6provided by RGD
    Official Full Name
    transglutaminase 6provided by RGD
    Primary source
    RGD:1565348
    See related
    EnsemblRapid:ENSRNOG00000006830 AllianceGenome:RGD:1565348
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565348
    Summary
    Predicted to enable protein-glutamine gamma-glutamyltransferase activity. Predicted to be involved in peptide cross-linking. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 35. Orthologous to human TGM6 (transglutaminase 6). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Spleen (RPKM 5.4), Thymus (RPKM 1.2) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tgm6 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (137771368..137809000)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (117324268..117355674)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (122644183..122680054)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL8-like Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nuclear ribonucleoprotein polypeptides B and B1 Neighboring gene small nucleolar RNA U3 Neighboring gene transmembrane channel-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Spinocerebellar ataxia 35: novel mutations in TGM6 with clinical and genetic characterization. Guo YC, et al. Neurology, 2014 Oct 21. PMID 25253745
    2. Identification of a highly reactive substrate peptide for transglutaminase 6 and its use in detecting transglutaminase activity in the skin epidermis. Fukui M, et al. FEBS J, 2013 Mar. PMID 23331848
    3. Spinocerebellar ataxia type 35 (SCA35)-associated transglutaminase 6 mutants sensitize cells to apoptosis. Guan WJ, et al. Biochem Biophys Res Commun, 2013 Jan 11. PMID 23206699
    4. Exome sequencing and network analysis identifies shared mechanisms underlying spinocerebellar ataxia. Nibbeling EAR, et al. Brain, 2017 Nov 1. PMID 29053796
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-glutamine gamma-glutamyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-glutamine gamma-glutamyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptide cross-linking IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein-glutamine gamma-glutamyltransferase 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      137771368..137809000
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284796.1 → XP_063140866.1  protein-glutamine gamma-glutamyltransferase 6

      Related
      ENSRNOP00000009097.5, ENSRNOT00000009097.6
    Nucleotide Protein Strain
    Heading Accession and Version

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