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    Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29578, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Hnrnpa1provided by RGD
    Official Full Name
    heterogeneous nuclear ribonucleoprotein A1provided by RGD
    Primary source
    RGD:69234
    See related
    EnsemblRapid:ENSRNOG00000036839 AllianceGenome:RGD:69234
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hnrpa1; hnRNP A1
    Summary
    Enables nucleic acid binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; cellular response to potassium ion; and male gonad development. Located in nucleoplasmic periphery of the nuclear pore complex. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 20; distal myopathy 3; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3; and tropical spastic paraparesis. Orthologous to several human genes including HNRNPA1L2 (heterogeneous nuclear ribonucleoprotein A1 like 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 954.1), Spleen (RPKM 755.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hnrnpa1 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (136253633..136260085)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (134375318..134381610)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (144865302..144871592)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093746 Neighboring gene uncharacterized LOC103692988 Neighboring gene single-strand-selective monofunctional uracil-DNA glycosylase 1 Neighboring gene chromobox 5 Neighboring gene nuclear factor, erythroid 2 Neighboring gene COPI coat complex subunit zeta 1 Neighboring gene microRNA 148b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Studies of the strand-annealing activity of mammalian hnRNP complex protein A1. Kumar A, et al. Biochemistry, 1990 Dec 4. PMID 1703006
    2. Autoimmunity due to molecular mimicry as a cause of neurological disease. Levin MC, et al. Nat Med, 2002 May. PMID 11984596, Free PMC Article
    3. Molecular mimicry: cross-reactive antibodies from patients with immune-mediated neurologic disease inhibit neuronal firing. Kalume F, et al. J Neurosci Res, 2004 Jul 1. PMID 15197740
    4. Exon silencing by UAGG motifs in response to neuronal excitation. An P, et al. PLoS Biol, 2007 Feb. PMID 17298175, Free PMC Article
    5. Increase in hnRNPA1 Expression Suffices to Kill Motor Neurons in Transgenic Rats. Huang B, et al. Int J Mol Sci, 2023 Nov 11. PMID 38003404, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Increase in hnRNPA1 Expression Suffices to Kill Motor Neurons in Transgenic Rats.
      Title: Increase in hnRNPA1 Expression Suffices to Kill Motor Neurons in Transgenic Rats.
    2. Data indicate that heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) participates in the IRES (internal ribosome entry site) -dependent translation of sterol-regulatory-element-binding protein 1 (SREBP-1a) mRNA through RNA-protein interaction.
      Title: hnRNP A1 mediates the activation of the IRES-dependent SREBP-1a mRNA translation in response to endoplasmic reticulum stress.
    3. data show that hnRNP A1 is an important Quaking target that contributes to its control of myelin gene expression
      Title: Quaking regulates Hnrnpa1 expression through its 3' UTR in oligodendrocyte precursor cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA/DNA annealing activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G-rich strand telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables RNA strand annealing activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables miRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables miRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables pre-mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables single-stranded DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables single-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables telomeric repeat-containing RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to epidermal growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to glucose starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to potassium ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to sodium arsenite ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to sodium arsenite ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in import into nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lung development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in male gonad development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear export ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear export ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of action potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to endoplasmic reticulum stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasmic periphery of the nuclear pore complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein A1
    Names
    HDP
    helix-destabilizing protein
    hnRNP core protein A1
    single-strand RNA-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399274.1 → NP_001386203.1  heterogeneous nuclear ribonucleoprotein A1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6ALC1, A6KD00
      Related
      ENSRNOP00000074880.3, ENSRNOT00000091596.3
      Conserved Domains (3) summary
      pfam11627
      Location:308 → 345
      HnRNPA1; Nuclear factor hnRNPA1
      cd12582
      Location:105 → 184
      RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
      cd12761
      Location:12 → 92
      RRM1_hnRNPA1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and similar proteins

    2. NM_017248.3 → NP_058944.2  heterogeneous nuclear ribonucleoprotein A1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      P04256
      UniProtKB/TrEMBL
      F7FEZ6, Q5I0M7
      Related
      ENSRNOP00000052160.6, ENSRNOT00000055285.6
      Conserved Domains (3) summary
      pfam11627
      Location:255 → 292
      HnRNPA1; Nuclear factor hnRNPA1
      cd12582
      Location:105 → 184
      RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
      cd12761
      Location:12 → 92
      RRM1_hnRNPA1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      136253633..136260085
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263120.1 → XP_063119190.1  heterogeneous nuclear ribonucleoprotein A1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ALC1, A6KD00

    2. XM_063263121.1 → XP_063119191.1  heterogeneous nuclear ribonucleoprotein A1 isoform X2

      UniProtKB/TrEMBL
      F7FEZ6, Q5I0M7
      Related
      ENSRNOP00000094714.2, ENSRNOT00000113929.2

    RNA

    1. XR_010052947.1 RNA Sequence

      Related
      ENSRNOT00000154593.1

    2. XR_356017.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04256.3 GenPept UniProtKB/Swiss-Prot:P04256

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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