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Hes1 hes family bHLH transcription factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29577, updated on 14-Nov-2024

Summary

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Official Symbol: Hes1provided by RGD
Official Full Name: hes family bHLH transcription factor 1provided by RGD
Primary source: RGD:62081
See related: EnsemblRapid:ENSRNOG00000001720 AllianceGenome:RGD:62081
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including JUN kinase binding activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription corepressor binding activity. Involved in several processes, including cellular response to cytokine stimulus; regulation of gene expression; and regulation of gliogenesis. Located in chromatin and nuclear matrix. Used to study chronic myeloid leukemia and epilepsy. Biomarker of acute kidney failure. Orthologous to human HES1 (hes family bHLH transcription factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 174.2), Heart (RPKM 138.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Hes1 in Genome Data Viewer

Location:: 11q22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (84210632..84213045, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (70705763..70708176, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (74312837..74315249, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KDM6B Negatively Regulates the Neurogenesis Potential of Apical Papilla Stem Cells via HES1.
Title: KDM6B Negatively Regulates the Neurogenesis Potential of Apical Papilla Stem Cells via HES1.
The Notch1/Hes1 signaling pathway affects autophagy by adjusting DNA methyltransferases expression in a valproic acid-induced autism spectrum disorder model.
Title: The Notch1/Hes1 signaling pathway affects autophagy by adjusting DNA methyltransferases expression in a valproic acid-induced autism spectrum disorder model.
the results in this study indicated nerve injury diminishes spinal Hes1-dependent suppression of CDK9-dependent RNAPII phosphorylation on the mGluR5 promoter that possibly enhances mGluR5 transcription/expression for neuropathic pain development.
Title: Transcription Repressor Hes1 Contributes to Neuropathic Pain Development by Modifying CDK9/RNAPII-Dependent Spinal mGluR5 Transcription.
Penehyclidine hydrochloride alleviates LPS-induced ALI by ameliorating ER stress-mediated apoptosis and promoting Hes1/Notch1 signaling in vivo and in vitro.
Title: Penehyclidine hydrochloride defends against LPS-induced ALI in rats by mitigating endoplasmic reticulum stress and promoting the Hes1/Notch1 pathway.
MiR-182 alleviates the development of cyanotic congenital heart disease by suppressing HES1
Title: MiR-182 alleviates the development of cyanotic congenital heart disease by suppressing HES1.
This study showed that overexpression of microRNA381 promotes cell proliferation of neurocytes in spinal cord injury via Hes1 expression.
Title: MicroRNA‑381/Hes1 is a potential therapeutic target for spinal cord injury.
Hes1 is upregulated and mediates cardioprotection provided by ischemic postconditioning and suggest that Hes1 is a potential new target for the treatment of ischemic cardiomyopathy.
Title: Hes1 is upregulated by ischemic postconditioning and contributes to cardioprotection.
Notch1 signaling appears to interact with TGF-beta/BMP signaling and co-regulates Hes1 expression in activated hepatic stellate cells.
Title: Hes1, an important gene for activation of hepatic stellate cells, is regulated by Notch1 and TGF-β/BMP signaling.
Hes-1 may play an important role in the pathogenesis of asthma.
Title: [Relationship between Hes-1 and airway inflammation and remodeling in a rat model of asthma].
The Jagged-2/Notch-1/Hes-1 signaling pathway is involved in intestinal epithelium regeneration early after I/R injury by increasing crypt epithelial cell proliferation.
Title: The jagged-2/notch-1/hes-1 pathway is involved in intestinal epithelium regeneration after intestinal ischemia-reperfusion injury.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:259614 (e-PCR)
- UniSTS:259614

Hes1 (e-PCR), detects polymorphism
- UniSTS:259614

Hes1 (e-PCR), detects polymorphism
- UniSTS:265714

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables E-box binding	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	IDA Inferred from Direct Assay more info	PubMed
enables E-box binding	IEA Inferred from Electronic Annotation more info
enables E-box binding	ISO Inferred from Sequence Orthology more info
enables HLH domain binding	IEA Inferred from Electronic Annotation more info
enables HLH domain binding	ISO Inferred from Sequence Orthology more info
enables JUN kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables N-box binding	IBA Inferred from Biological aspect of Ancestor more info
enables N-box binding	IDA Inferred from Direct Assay more info	PubMed
enables N-box binding	IEA Inferred from Electronic Annotation more info
enables N-box binding	ISO Inferred from Sequence Orthology more info
enables N-box binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables histone deacetylase binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-folding chaperone binding	IEA Inferred from Electronic Annotation more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Cajal-Retzius cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of Cajal-Retzius cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in S-shaped body morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in S-shaped body morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in T cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in adenohypophysis development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adenohypophysis development	ISO Inferred from Sequence Orthology more info
involved_in amacrine cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of amacrine cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in anterior/posterior pattern specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in aorta morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in artery morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in ascending aorta morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in ascending aorta morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cardiac neural crest cell development involved in outflow tract morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cardiac neural crest cell development involved in outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell fate commitment	ISO Inferred from Sequence Orthology more info
involved_in cell fate determination	IEA Inferred from Electronic Annotation more info
acts_upstream_of cell fate determination	ISO Inferred from Sequence Orthology more info
involved_in cell maturation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell maturation	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell morphogenesis involved in neuron differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell morphogenesis involved in neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to fatty acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to nerve growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in cochlea development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cochlea development	ISO Inferred from Sequence Orthology more info
involved_in comma-shaped body morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in comma-shaped body morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in common bile duct development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within common bile duct development	ISO Inferred from Sequence Orthology more info
involved_in embryonic heart tube morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic heart tube morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in establishment of epithelial cell polarity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of epithelial cell polarity	ISO Inferred from Sequence Orthology more info
involved_in forebrain radial glial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in glomerulus vasculature development	IEA Inferred from Electronic Annotation more info
involved_in glomerulus vasculature development	ISO Inferred from Sequence Orthology more info
involved_in hair cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hindbrain morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hindbrain morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inhibition of neuroepithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in inner ear auditory receptor cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of inner ear auditory receptor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in inner ear receptor cell stereocilium organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inner ear receptor cell stereocilium organization	ISO Inferred from Sequence Orthology more info
involved_in labyrinthine layer blood vessel development	IEA Inferred from Electronic Annotation more info
involved_in labyrinthine layer blood vessel development	ISO Inferred from Sequence Orthology more info
involved_in lateral inhibition	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lateral inhibition	ISO Inferred from Sequence Orthology more info
involved_in liver development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within liver development	ISO Inferred from Sequence Orthology more info
involved_in lung development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
involved_in metanephric nephron tubule morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in metanephric nephron tubule morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in midbrain development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within midbrain development	ISO Inferred from Sequence Orthology more info
involved_in midbrain-hindbrain boundary morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within midbrain-hindbrain boundary morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amacrine cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of amacrine cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcium ion import	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell fate determination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell fate determination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of forebrain neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of glial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of inner ear auditory receptor cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of inner ear auditory receptor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inner ear receptor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of oligodendrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oligodendrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of pancreatic A cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of pancreatic A cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of pro-B cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of pro-B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of pro-B cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of stem cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stomach neuroendocrine cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of stomach neuroendocrine cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tube development	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuroendocrine cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuronal stem cell population maintenance	IDA Inferred from Direct Assay more info	PubMed
involved_in neuronal stem cell population maintenance	IEA Inferred from Electronic Annotation more info
involved_in neuronal stem cell population maintenance	ISO Inferred from Sequence Orthology more info
involved_in oculomotor nerve development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within oculomotor nerve development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pancreas development	ISO Inferred from Sequence Orthology more info
involved_in pancreatic A cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of pancreatic A cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pattern specification process	ISO Inferred from Sequence Orthology more info
involved_in pharyngeal arch artery morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in pharyngeal arch artery morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pituitary gland development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of BMP signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of astrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of astrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of astrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic cell cycle, embryonic	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitotic cell cycle, embryonic	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of fat cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in regulation of receptor signaling pathway via JAK-STAT	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of secondary heart field cardioblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of secondary heart field cardioblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of timing of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of timing of neuron differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of timing of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in renal interstitial fibroblast development	IEA Inferred from Electronic Annotation more info
involved_in renal interstitial fibroblast development	ISO Inferred from Sequence Orthology more info
involved_in response to alkaloid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to thyroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in smoothened signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in somatic stem cell population maintenance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within somatic stem cell population maintenance	ISO Inferred from Sequence Orthology more info
involved_in stomach neuroendocrine cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of stomach neuroendocrine cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in telencephalon development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within telencephalon development	ISO Inferred from Sequence Orthology more info
involved_in thymus development	IEA Inferred from Electronic Annotation more info
involved_in thymus development	ISO Inferred from Sequence Orthology more info
involved_in trochlear nerve development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within trochlear nerve development	ISO Inferred from Sequence Orthology more info
involved_in ureteric bud morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in vascular associated smooth muscle cell development	IEA Inferred from Electronic Annotation more info
involved_in vascular associated smooth muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in ventricular septum development	ISO Inferred from Sequence Orthology more info
involved_in ventricular septum morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in ventricular septum morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcription factor HES-1

Names: RHL; hairy and enhancer of split 1; hairy-like protein

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024360.4 → NP_077336.3 transcription factor HES-1

See identical proteins and their annotated locations for NP_077336.3

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

Q04666

UniProtKB/TrEMBL

A6JRV7, D4ADT9

Related

ENSRNOP00000002346.8, ENSRNOT00000002346.9

Conserved Domains (2) summary

cd11459
Location:33 → 95

bHLH-O_HES1_4; basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split HES-1, HES-4 and similar proteins

pfam07527
Location:110 → 148

Hairy_orange; Hairy Orange

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

84210632..84213045 complement

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mRNA and Protein(s)

XM_039088256.1 → XP_038944184.1 transcription factor HES-1 isoform X1

Conserved Domains (1) summary

pfam07527
Location:1 → 31

Hairy_orange; Hairy Orange