Myh7 myosin heavy chain 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Myh7provided by RGD
Official Full Name: myosin heavy chain 7provided by RGD
Primary source: RGD:62030
See related: EnsemblRapid:ENSRNOG00000016983 AllianceGenome:RGD:62030
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bmyo; Myhcb; myHC-beta; myHC-slow
Summary: Enables several functions, including ATP binding activity; ATP hydrolysis activity; and identical protein binding activity. Involved in several processes, including cellular response to 3,3',5-triiodo-L-thyronine; cellular response to angiotensin; and cellular response to hydrogen peroxide. Located in myosin filament and sarcomere. Part of muscle myosin complex. Biomarker of congestive heart failure; hypertension; hypothyroidism; and myocardial infarction. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); congenital heart disease (multiple); distal myopathy 1; and hyaline body myopathy (multiple). Orthologous to human MYH7 (myosin heavy chain 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 18484.9) and Muscle (RPKM 5773.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 15p13

Exon count:: 40

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (32416525..32439851, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (28446550..28469888, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (33605769..33657761, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

T3 Critically Affects the Mhrt/Brg1 Axis to Regulate the Cardiac MHC Switch: Role of an Epigenetic Cross-Talk.
Title: T3 Critically Affects the Mhrt/Brg1 Axis to Regulate the Cardiac MHC Switch: Role of an Epigenetic Cross-Talk.
JMJD3 may be a key epigenetic regulator of beta-MHC expression in cardiomyocytes and a potential therapeutic target for cardiac hypertrophy.
Title: JMJD3 inhibition protects against isoproterenol-induced cardiac hypertrophy by suppressing β-MHC expression.
TnT mutation F72L leads to contractile changes that are linked to dilated cardiomyopathy in the presence of MYH6 and hypertrophic cardiomyopathy in the presence of MYH7.
Title: Rat cardiac troponin T mutation (F72L)-mediated impact on thin filament cooperativity is divergently modulated by α- and β-myosin heavy chain isoforms.
T3 treatment in hypothyroid animals caused beta-MHC mRNA to decline more rapidly than beta-MHC hnRNA, demonstrating, for the first time, a posttranscriptional mechanism(s).
Title: Posttranscriptional regulation of myosin heavy chain expression in the heart by triiodothyronine.
Bmyo cardiac myocytes were more responsive to changes in sarcomere length and lattice spacing.
Title: Sarcomere length dependence of rat skinned cardiac myocyte mechanical properties: dependence on myosin heavy chain.
Suggest the involvement of epigenetic processes in the developmental regulation of cardiac myosin heavy chain gene locus.
Title: Intergenic transcription and developmental regulation of cardiac myosin heavy chain genes.
results suggest that the betae3 site functions as a putative functional overload responsive element in the rat beta-MHC gene promoter
Title: Functional overload increases beta-MHC promoter activity in rodent fast muscle via the proximal MCAT (betae3) site.
visual stimulation may play a role in the signals that regulate both nmMyH IIB and EO-MyHC developmental transitions
Title: Postnatal changes in the developing rat extraocular muscles.
higher levels of MHC-beta and dephosphorylated phospholamban may contribute to more contractile dysfunction in male than in female diabetic rat hearts
Title: Gender differences in myosin heavy chain-beta and phosphorylated phospholamban in diabetic rat hearts.
cross-bridge cycling, under high strain, for alpha-MHC is three times higher than for beta-MHC.
Title: Impact of beta-myosin heavy chain isoform expression on cross-bridge cycling kinetics.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Myh7 (e-PCR), detects polymorphism
- UniSTS:463417

RH140569 (e-PCR)
- UniSTS:222638

Myh7 (e-PCR), detects polymorphism
- UniSTS:530876

MARC_5445-5446:996690391:1 (e-PCR)
- UniSTS:269515

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables ATP hydrolysis activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microfilament motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables microfilament motor activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ATP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in ATP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in adult heart development	IBA Inferred from Biological aspect of Ancestor more info
involved_in adult heart development	IEA Inferred from Electronic Annotation more info
involved_in adult heart development	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiac muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle hypertrophy in response to stress	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to 3,3',5-triiodo-L-thyronine	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to angiotensin	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in muscle filament sliding	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle filament sliding	IEA Inferred from Electronic Annotation more info
involved_in muscle filament sliding	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate	IEA Inferred from Electronic Annotation more info
involved_in regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in regulation of slow-twitch skeletal muscle fiber contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of slow-twitch skeletal muscle fiber contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of the force of heart contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of the force of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of the force of skeletal muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of the force of skeletal muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in skeletal muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in skeletal muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in striated muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in transition between fast and slow fiber	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transition between fast and slow fiber	ISO Inferred from Sequence Orthology more info
involved_in ventricular cardiac muscle tissue morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in ventricular cardiac muscle tissue morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Z disc	IEA Inferred from Electronic Annotation more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of muscle myosin complex	IDA Inferred from Direct Assay more info	PubMed
located_in myofibril	IDA Inferred from Direct Assay more info	PubMed
located_in myofibril	ISO Inferred from Sequence Orthology more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
part_of myosin complex	ISO Inferred from Sequence Orthology more info
is_active_in myosin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in myosin filament	IDA Inferred from Direct Assay more info	PubMed
located_in myosin filament	IEA Inferred from Electronic Annotation more info
located_in myosin filament	ISO Inferred from Sequence Orthology more info
located_in sarcomere	IDA Inferred from Direct Assay more info	PubMed
located_in stress fiber	IEA Inferred from Electronic Annotation more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myosin-7

Names: beta myosin heavy chain; myosin heavy chain polypeptide 7 cardiac muscle fetal; myosin heavy chain, cardiac muscle, fetal; myosin heavy chain, polypeptide 7; myosin, heavy chain 7, cardiac muscle, beta; myosin, heavy polypeptide 7, cardiac muscle, beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017240.2 → NP_058936.1 myosin-7

See identical proteins and their annotated locations for NP_058936.1

Status: PROVISIONAL

Source sequence(s)

X15939

UniProtKB/Swiss-Prot

P02563, P02564, Q63351

Related

ENSRNOP00000024186.3, ENSRNOT00000024186.5

Conserved Domains (7) summary

cd01377
Location:99 → 766

MYSc_class_II; class II myosins, motor domain

pfam00063
Location:87 → 766

Myosin_head; Myosin head (motor domain)

pfam01576
Location:846 → 1923

Myosin_tail_1; Myosin tail

pfam02736
Location:35 → 72

Myosin_N; Myosin N-terminal SH3-like domain

pfam07851
Location:1740 → 1830

TMPIT; TMPIT-like protein

cl00817
Location:1132 → 1293

MM_CoA_mutase; Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of ...

cl12013
Location:1232 → 1424

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

32416525..32439851 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006251951.4 → XP_006252013.1 myosin-7 isoform X1

See identical proteins and their annotated locations for XP_006252013.1

UniProtKB/Swiss-Prot

P02563, Q63351

UniProtKB/TrEMBL

A6KGY1, G3V8B0

Conserved Domains (7) summary

cd01377
Location:99 → 766

MYSc_class_II; class II myosins, motor domain

pfam00063
Location:87 → 766

Myosin_head; Myosin head (motor domain)

pfam01576
Location:846 → 1923

Myosin_tail_1; Myosin tail

pfam02736
Location:35 → 72

Myosin_N; Myosin N-terminal SH3-like domain

pfam07851
Location:1740 → 1830

TMPIT; TMPIT-like protein

cl00817
Location:1132 → 1293

MM_CoA_mutase; Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of ...

cl12013
Location:1232 → 1424

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_063274187.1 → XP_063130257.1 myosin-7 isoform X1

UniProtKB/TrEMBL

A6KGY1, G3V8B0