Tbck TBC1 domain containing kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tbckprovided by RGD
Official Full Name: TBC1 domain containing kinaseprovided by RGD
Primary source: RGD:1307816
See related: EnsemblRapid:ENSRNOG00000011454 AllianceGenome:RGD:1307816
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tbckl; RGD1307816
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in actin cytoskeleton organization; cell population proliferation; and regulation of TOR signaling. Predicted to be located in cytoplasm; midbody; and mitotic spindle. Human ortholog(s) of this gene implicated in infantile hypotonia with psychomotor retardation and characteristic facies-3. Orthologous to human TBCK (TBC1 domain containing kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 77.1), Lung (RPKM 56.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q43

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (223849758..224022097)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (221175749..221348058)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (237751646..237958497)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of TOR signaling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: TBC domain-containing protein kinase-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001415033.1 → NP_001401962.1 TBC domain-containing protein kinase-like protein

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A0G2K9Q0

Related

ENSRNOP00000075082.2, ENSRNOT00000083937.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

223849758..224022097

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102101.2 → XP_038958029.1 TBC domain-containing protein kinase-like protein isoform X2

Conserved Domains (3) summary

COG5210
Location:335 → 546

COG5210; GTPase-activating protein [General function prediction only]

cl02495
Location:467 → 546

RabGAP-TBC; Rab-GTPase-TBC domain

cl21453
Location:43 → 273

PKc_like; Protein Kinases, catalytic domain
XM_063281663.1 → XP_063137733.1 TBC domain-containing protein kinase-like protein isoform X1
XM_039102098.2 → XP_038958026.1 TBC domain-containing protein kinase-like protein isoform X1

UniProtKB/TrEMBL

A0A8I6ALH8

Conserved Domains (3) summary

smart00164
Location:328 → 532

TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

cl00125
Location:633 → 744

RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...

cl21453
Location:11 → 134

PKc_like; Protein Kinases, catalytic domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001134513.1: Suppressed sequence

Description

NM_001134513.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.