Slc1a2 solute carrier family 1 member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc1a2provided by RGD
Official Full Name: solute carrier family 1 member 2provided by RGD
Primary source: RGD:3697
See related: EnsemblRapid:ENSRNOG00000005479 AllianceGenome:RGD:3697
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Glt; Eaat2; Glt-1
Summary: Enables high-affinity L-glutamate transmembrane transporter activity. Involved in L-glutamate transmembrane transport. Located in several cellular components, including astrocyte projection; dendrite; and presynaptic membrane. Part of membrane protein complex. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 41. Orthologous to human SLC1A2 (solute carrier family 1 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 1451.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 3q32

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (109460109..109590445)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (89005129..89135469)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (92518679..92665731)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HSP90beta regulates EAAT2 expression and participates in ischemia-reperfusion injury in rats.
Title: HSP90β regulates EAAT2 expression and participates in ischemia‑reperfusion injury in rats.
Inhibition of mGluR5 alters BDNF/TrkB and GLT-1 expression in the prefrontal cortex and hippocampus and ameliorates PTSD-like behavior in rats.
Title: Inhibition of mGluR5 alters BDNF/TrkB and GLT-1 expression in the prefrontal cortex and hippocampus and ameliorates PTSD-like behavior in rats.
Bone marrow stromal cells-derived exosomes reduce neurological damage in traumatic brain injury through the miR-124-3p/p38 MAPK/GLT-1 axis.
Title: Bone marrow stromal cells-derived exosomes reduce neurological damage in traumatic brain injury through the miR-124-3p/p38 MAPK/GLT-1 axis.
LncRNA BIRF Promotes Brain Ischemic Tolerance Induced By Cerebral Ischemic Preconditioning Through Upregulating GLT-1 via Sponging miR-330-5p.
Title: LncRNA BIRF Promotes Brain Ischemic Tolerance Induced By Cerebral Ischemic Preconditioning Through Upregulating GLT-1 via Sponging miR-330-5p.
Induction of Parkinsonian-Like Changes via Targeted Downregulation of Astrocytic Glutamate Transporter GLT-1 in the Striatum.
Title: Induction of Parkinsonian-Like Changes via Targeted Downregulation of Astrocytic Glutamate Transporter GLT-1 in the Striatum.
Downregulation of astroglial glutamate transporter GLT-1 in the lateral habenula is associated with depressive-like behaviors in a rat model of Parkinson's disease.
Title: Downregulation of astroglial glutamate transporter GLT-1 in the lateral habenula is associated with depressive-like behaviors in a rat model of Parkinson's disease.
Glutamate transporter 1-expressing glia in the rat substantia nigra-Morphometric analysis and relationships to synapses.
Title: Glutamate transporter 1-expressing glia in the rat substantia nigra-Morphometric analysis and relationships to synapses.
Midazolam contributes to neuroprotection against hypoxia/reoxygenation-induced brain injury in neonatal rats via regulation of EAAT2.
Title: Midazolam contributes to neuroprotection against hypoxia/reoxygenation-induced brain injury in neonatal rats via regulation of EAAT2.
RAGE Signaling pathway in hippocampus dentate gyrus involved in GLT-1 decrease induced by chronic unpredictable stress in rats.
Title: RAGE Signaling pathway in hippocampus dentate gyrus involved in GLT-1 decrease induced by chronic unpredictable stress in rats.
Rapid recycling of glutamate transporters on the astroglial surface.
Title: Rapid recycling of glutamate transporters on the astroglial surface.

Submit: New GeneRIF Correction See all GeneRIFs (159)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc1a2 (e-PCR), detects polymorphism
- UniSTS:144416

BF386143 (e-PCR)
- UniSTS:243590

D43796 (e-PCR)
- UniSTS:124833

D3Rat27 (e-PCR)
- UniSTS:118766

RH138571 (e-PCR)
- UniSTS:220658

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-glutamate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-glutamate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables acidic amino acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables cysteine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables cysteine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables glutamate:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables glutamate:sodium symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables high-affinity L-glutamate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables high-affinity L-glutamate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables high-affinity L-glutamate transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables high-affinity L-glutamate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables high-affinity L-glutamate transmembrane transporter activity	TAS Traceable Author Statement more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic anion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables monoatomic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables neutral L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in D-aspartate import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in D-aspartate import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-alpha-amino acid transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in L-aspartate import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in L-aspartate import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-aspartate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-glutamate import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-glutamate import across plasma membrane	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within L-glutamate import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-glutamate import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-glutamate import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in L-glutamate transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within L-glutamate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-glutamate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in acidic amino acid transport	IEA Inferred from Electronic Annotation more info
involved_in adult behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adult behavior	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cocaine	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cocaine	ISO Inferred from Sequence Orthology more info
involved_in cysteine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in dicarboxylic acid transport	IEA Inferred from Electronic Annotation more info
involved_in glutathione biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glutathione biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in monoatomic anion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic anion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system development	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter reuptake	IEA Inferred from Electronic Annotation more info
involved_in neurotransmitter reuptake	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter transport	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of D-glucose import	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of D-glucose import	ISO Inferred from Sequence Orthology more info
involved_in protein homotrimerization	IEA Inferred from Electronic Annotation more info
involved_in protein homotrimerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotrimerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to amino acid	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to amino acid	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to light stimulus	ISO Inferred from Sequence Orthology more info
involved_in response to wounding	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to wounding	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in telencephalon development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within telencephalon development	ISO Inferred from Sequence Orthology more info
involved_in visual behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual behavior	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in astrocyte projection	IDA Inferred from Direct Assay more info	PubMed
located_in astrocyte projection	IEA Inferred from Electronic Annotation more info
located_in astrocyte projection	ISO Inferred from Sequence Orthology more info
located_in axolemma	IEA Inferred from Electronic Annotation more info
located_in axolemma	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cell body	IEA Inferred from Electronic Annotation more info
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
part_of membrane protein complex	IDA Inferred from Direct Assay more info	PubMed
part_of membrane protein complex	IEA Inferred from Electronic Annotation more info
part_of membrane protein complex	ISO Inferred from Sequence Orthology more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in neuron projection terminus	IEA Inferred from Electronic Annotation more info
located_in neuron projection terminus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in vesicle	IEA Inferred from Electronic Annotation more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: excitatory amino acid transporter 2

Names: glial glutamate transporter GLT1/V1; glial glutamate transporter GLT1/V2; glial glutamate transporter GLT1/V3; glial glutamate transporter GLT1/V4; glutamate transporter 1; high affinity glucose transporter; sodium-dependent glutamate/aspartate transporter 2; solute carrier family 1 (glial high affinity glutamate transporter), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001035233.2 → NP_001030310.2 excitatory amino acid transporter 2 isoform b

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6AL04, A6HNP3, Q8K5B5

Related

ENSRNOP00000094162.2, ENSRNOT00000109994.2

Conserved Domains (1) summary

pfam00375
Location:46 → 495

SDF; Sodium:dicarboxylate symporter family
NM_001302089.2 → NP_001289018.1 excitatory amino acid transporter 2 isoform c

See identical proteins and their annotated locations for NP_001289018.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

P31596

UniProtKB/TrEMBL

A6HNP4

Related

ENSRNOP00000100271.1, ENSRNOT00000118194.2

Conserved Domains (1) summary

pfam00375
Location:43 → 492

SDF; Sodium:dicarboxylate symporter family
NM_017215.3 → NP_058911.2 excitatory amino acid transporter 2 isoform a

See identical proteins and their annotated locations for NP_058911.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

P31596

UniProtKB/TrEMBL

A6HNP2

Related

ENSRNOP00000112804.1, ENSRNOT00000155256.1

Conserved Domains (1) summary

pfam00375
Location:46 → 495

SDF; Sodium:dicarboxylate symporter family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

109460109..109590445

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063283237.1 → XP_063139307.1 excitatory amino acid transporter 2 isoform X3
XM_063283235.1 → XP_063139305.1 excitatory amino acid transporter 2 isoform X1

UniProtKB/TrEMBL

A0A8I6B5J7
XM_063283236.1 → XP_063139306.1 excitatory amino acid transporter 2 isoform X2

UniProtKB/TrEMBL

A0A8I6AS41