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    Mecr mitochondrial trans-2-enoyl-CoA reductase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29470, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mecrprovided by RGD
    Official Full Name
    mitochondrial trans-2-enoyl-CoA reductaseprovided by RGD
    Primary source
    RGD:3208
    See related
    EnsemblRapid:ENSRNOG00000028047 AllianceGenome:RGD:3208
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nrbf1
    Summary
    Enables signaling receptor binding activity. Predicted to be involved in fatty acid metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in childhood-onset dystonia with optic atrophy and basal ganglia abnormalities and optic atrophy. Orthologous to human MECR (mitochondrial trans-2-enoyl-CoA reductase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 104.8), Heart (RPKM 93.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mecr in Genome Data Viewer
    Location:
    5q36
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (149313765..149339964)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (144029684..144056373)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (150001281..150027407)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, receptor type, U Neighboring gene uncharacterized LOC134486998 Neighboring gene serine and arginine rich splicing factor 4 Neighboring gene transmembrane protein 200B Neighboring gene erythrocyte membrane protein band 4.1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MECR Mutations Cause Childhood-Onset Dystonia and Optic Atrophy, a Mitochondrial Fatty Acid Synthesis Disorder. Heimer G, et al. Am J Hum Genet, 2016 Dec 1. PMID 27817865, Free PMC Article
    2. Characterization of 2-enoyl thioester reductase from mammals. An ortholog of YBR026p/MRF1'p of the yeast mitochondrial fatty acid synthesis type II. Miinalainen IJ, et al. J Biol Chem, 2003 May 30. PMID 12654921
    3. Nuclear receptor binding factor-1 (NRBF-1), a protein interacting with a wide spectrum of nuclear hormone receptors. Masuda N, et al. Gene, 1998 Oct 23. PMID 9795230
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enoyl-[acyl-carrier-protein] reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enoyl-[acyl-carrier-protein] reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enoyl-[acyl-carrier-protein] reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables signaling receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of ceramide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of ceramide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in intracellular iron ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of intracellular iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of intracellular iron ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    enoyl-[acyl-carrier-protein] reductase, mitochondrial
    Names
    2-enoyl thioester reductase
    NRBF-1
    nuclear receptor-binding factor 1
    trans-2-enoyl-CoA reductase, mitochondrial
    NP_058905.1
    XP_063143328.1
    XP_063143329.1
    XP_063143330.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017209.1 → NP_058905.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_058905.1

      Status: PROVISIONAL

      Source sequence(s)
      AB015724
      UniProtKB/Swiss-Prot
      F1LPY7, Q9Z311
      UniProtKB/TrEMBL
      A0A140TAE6
      Related
      ENSRNOP00000031375.2, ENSRNOT00000034057.6
      Conserved Domains (2) summary
      cd08290
      Location:44 → 373
      ETR; 2-enoyl thioester reductase (ETR)
      COG0604
      Location:44 → 359
      Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      149313765..149339964
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287260.1 → XP_063143330.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X3

    2. XM_063287259.1 → XP_063143329.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X2

    3. XM_063287258.1 → XP_063143328.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X1

    RNA

    1. XR_005504375.2 RNA Sequence

    2. XR_010066346.1 RNA Sequence

    3. XR_005504376.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z311.1 GenPept UniProtKB/Swiss-Prot:Q9Z311

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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