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    Gap43 growth associated protein 43 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29423, updated on 2-Nov-2024

    Summary

    Official Symbol
    Gap43provided by RGD
    Official Full Name
    growth associated protein 43provided by RGD
    Primary source
    RGD:62071
    See related
    EnsemblRapid:ENSRNOG00000001528 AllianceGenome:RGD:62071
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Basp2
    Summary
    Enables lysophosphatidic acid binding activity; phosphatidylinositol phosphate binding activity; and phosphatidylserine binding activity. Involved in several processes, including regulation of postsynaptic specialization assembly; response to auditory stimulus; and tissue regeneration. Is active in GABA-ergic synapse and presynapse. Biomarker of middle cerebral artery infarction and visual epilepsy. Orthologous to human GAP43 (growth associated protein 43). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 663.7) See more
    Orthologs
    NEW
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    Genomic context

    See Gap43 in Genome Data Viewer
    Location:
    11q21
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (71882131..71975799)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (58376371..58470047)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (58624198..58717916)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC134481071 Neighboring gene limbic system-associated membrane protein Neighboring gene small nucleolar RNA SNORA32 Neighboring gene uncharacterized LOC108352336

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC156666

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables lysophosphatidic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables lysophosphatidic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol phosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylserine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within astrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in axon choice point recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within axon choice point recognition ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in axon regeneration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cell fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nervous system development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within radial glial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of postsynaptic specialization assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of postsynaptic specialization assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to auditory stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in tissue regeneration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tissue regeneration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in filopodium membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in growth cone membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    neuromodulin
    Names
    axonal membrane protein GAP-43
    brain abundant, membrane attached signal protein 2
    growth accentuating protein 43
    protein F1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017195.3NP_058891.1  neuromodulin

      See identical proteins and their annotated locations for NP_058891.1

      Status: VALIDATED

      Source sequence(s)
      BF560544, BI304179, X06338
      UniProtKB/Swiss-Prot
      A0JPM4, P07936
      UniProtKB/TrEMBL
      A6IR38
      Related
      ENSRNOP00000002091.3, ENSRNOT00000002091.6
      Conserved Domains (2) summary
      smart00015
      Location:3052
      IQ; Calmodulin-binding motif
      pfam06614
      Location:73226
      Neuromodulin; Neuromodulin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      71882131..71975799
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)