Bace1 beta-secretase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bace1provided by RGD
Official Full Name: beta-secretase 1provided by RGD
Primary source: RGD:2191
See related: EnsemblRapid:ENSRNOG00000016847 AllianceGenome:RGD:2191
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bace
Summary: Enables peptidase activity. Involved in several processes, including cellular response to amyloid-beta; cellular response to metal ion; and detection of mechanical stimulus involved in sensory perception of pain. Located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and neuronal cell body. Used to study dementia. Biomarker of Alzheimer's disease; sensory peripheral neuropathy; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human BACE1 (beta-secretase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 222.4), Heart (RPKM 151.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q22

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (55038842..55061138)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (46142060..46166268)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (50140092..50162388)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Determining Structural Changes for Ligand Recognition between Human and Rat Phosphorylated BACE1 in Silico and Its Phosphorylation by GSK3beta at Thr252 by in Vitro Studies.
Title: Determining Structural Changes for Ligand Recognition between Human and Rat Phosphorylated BACE1 in Silico and Its Phosphorylation by GSK3β at Thr252 by in Vitro Studies.
miR-29c-3p Attenuates beta-Amyloid-Induced Neurotoxicity in Alzheimer's Disease Through Regulating beta-Site Amyloid Precursor Protein-Cleaving Enzyme 1.
Title: miR-29c-3p Attenuates beta-Amyloid-Induced Neurotoxicity in Alzheimer's Disease Through Regulating beta-Site Amyloid Precursor Protein-Cleaving Enzyme 1.
MicroRNA-132-3p alleviates neuron apoptosis and impairments of learning and memory abilities in Alzheimer's disease by downregulation of HNRNPU stabilized BACE1.
Title: MicroRNA-132-3p alleviates neuron apoptosis and impairments of learning and memory abilities in Alzheimer's disease by downregulation of HNRNPU stabilized BACE1.
Effect of Global Brain Ischemia on Amyloid Precursor Protein Metabolism and Expression of Amyloid-Degrading Enzymes in Rat Cortex: Role in Pathogenesis of Alzheimer's Disease.
Title: Effect of Global Brain Ischemia on Amyloid Precursor Protein Metabolism and Expression of Amyloid-Degrading Enzymes in Rat Cortex: Role in Pathogenesis of Alzheimer's Disease.
Downregulation of lncRNA BACE1-AS improves dopamine-dependent oxidative stress in rats with Parkinson's disease by upregulating microRNA-34b-5p and downregulating BACE1.
Title: Downregulation of lncRNA BACE1-AS improves dopamine-dependent oxidative stress in rats with Parkinson's disease by upregulating microRNA-34b-5p and downregulating BACE1.
Effect of memantine on expression of Bace1-as and Bace1 genes in STZ-induced Alzheimeric rats.
Title: Effect of memantine on expression of Bace1-as and Bace1 genes in STZ-induced Alzheimeric rats.
Nogo66 promotes betaamyloid protein secretion via NgR/ROCKdependent BACE1 activation.
Title: Nogo‑66 promotes β‑amyloid protein secretion via NgR/ROCK‑dependent BACE1 activation.
that NEAT1 worked as a regulating factor to promote the development of AD via modulating miR-124/BACE1 axis
Title: The long-non-coding RNA NEAT1 is a novel target for Alzheimer's disease progression via miR-124/BACE1 axis.
Study utilizing glutamate excitotoxicity model in rat cortical primary cell cultures suggests for the first time a more direct action of BACE1 on the hyperphosphorylation state of tau (implemented in Alzheimer's disease pathogenesis) that is mediated through cPLA2 and desaturases SCD1 and FADS6 modulation during glutamate excitotoxicity.
Title: cPLA2 and desaturases underlie the tau hyperphosphorylation offset induced by BACE knock-down in neuronal primary cultures.
Beta-site APP cleaving enzyme 1 knockout (Bace1-/-) mice and rats differed in body weight, spontaneous locomotor activity, and prepulse inhibition of startle.
Title: BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and rats.

Submit: New GeneRIF Correction See all GeneRIFs (46)

General gene information

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Markers

RH129813 (e-PCR)
- UniSTS:213102

RH138821 (e-PCR)
- UniSTS:220908

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables aspartic-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables aspartic-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables aspartic-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in amyloid precursor protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in amyloid-beta metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in amyloid-beta metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within amyloid-beta metabolic process	ISO Inferred from Sequence Orthology more info
involved_in amyloid-beta metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within amyloid-beta metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in amyloid-beta metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to amyloid-beta	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to copper ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to manganese ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane protein ectodomain proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in prepulse inhibition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in protein processing	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to lead ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in signaling receptor ligand precursor processing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in hippocampal mossy fiber to CA3 synapse	ISO Inferred from Sequence Orthology more info
located_in late endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in multivesicular body	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	IEA Inferred from Electronic Annotation more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: beta-secretase 1

Names: ASP2; asp 2; aspartyl protease 2; beta-site APP cleaving enzyme 1; beta-site amyloid precursor protein cleaving enzyme 1; memapsin-2; membrane-associated aspartic protease 2

NP_062077.1

EC 3.4.23.46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019204.2 → NP_062077.1 beta-secretase 1 precursor

See identical proteins and their annotated locations for NP_062077.1

Status: VALIDATED

Source sequence(s)

AF190727, JAXUCZ010000008

UniProtKB/Swiss-Prot

P56819

UniProtKB/TrEMBL

A0A8I6AHF6, A6J452, A6J453

Related

ENSRNOP00000022796.5, ENSRNOT00000022796.8

Conserved Domains (1) summary

cd05473
Location:72 → 437

beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease