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    Bcap31 B-cell receptor-associated protein 31 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293852, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Bcap31provided by RGD
    Official Full Name
    B-cell receptor-associated protein 31provided by RGD
    Primary source
    RGD:1302944
    See related
    EnsemblRapid:ENSRNOG00000055756 AllianceGenome:RGD:1302944
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bap31
    Summary
    Predicted to enable MHC class I protein binding activity. Predicted to be involved in several processes, including positive regulation of proteolysis involved in protein catabolic process; positive regulation of retrograde protein transport, ER to cytosol; and protein localization to organelle. Predicted to act upstream of or within immune response. Located in Golgi cisterna membrane; clathrin-coated vesicle; and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in deafness, dystonia, and cerebral hypomyelination and sensorineural hearing loss. Orthologous to human BCAP31 (B cell receptor associated protein 31). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Adrenal (RPKM 676.7), Kidney (RPKM 499.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bcap31 in Genome Data Viewer
    Location:
    Xq37
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (156548911..156581002, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (151397567..151429666, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (157094365..157126397)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene pregnancy up-regulated nonubiquitous CaM kinase Neighboring gene solute carrier family 6 member 8 Neighboring gene ATP binding cassette subfamily D member 1 Neighboring gene translocase of outer mitochondrial membrane 5, pseudogene 1 Neighboring gene uncharacterized LOC134484226

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Novel immunohistochemical monoclonal antibody against rat B cell receptor Associated Protein 31 (BAP31). Song C, et al. Hybridoma (Larchmt), 2009 Oct. PMID 19857118
    2. Mutations in BCAP31 cause a severe X-linked phenotype with deafness, dystonia, and central hypomyelination and disorganize the Golgi apparatus. Cacciagli P, et al. Am J Hum Genet, 2013 Sep 5. PMID 24011989, Free PMC Article
    3. Molecular cloning and characterization of a transmembrane surface antigen in human cells. Li E, et al. Eur J Biochem, 1996 Jun 15. PMID 8706661
    4. The specificity of association of the IgD molecule with the accessory proteins BAP31/BAP29 lies in the IgD transmembrane sequence. Adachi T, et al. EMBO J, 1996 Apr 1. PMID 8612576, Free PMC Article
    5. Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction. Iwasawa R, et al. EMBO J, 2011 Feb 2. PMID 21183955, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94221

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MHC class I protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein localization to endoplasmic reticulum exit site ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi cisterna membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondria-associated endoplasmic reticulum membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    B-cell receptor-associated protein 31

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004224.1 → NP_001004224.1  B-cell receptor-associated protein 31

      See identical proteins and their annotated locations for NP_001004224.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079182
      UniProtKB/TrEMBL
      A0A0G2JXK2, A0A8I5ZTY8, Q6AY58
      Related
      ENSRNOP00000082446.2, ENSRNOT00000099703.2
      Conserved Domains (2) summary
      pfam05529
      Location:1 → 136
      Bap31; B-cell receptor-associated protein 31-like
      pfam18035
      Location:192 → 245
      Bap31_Bap29_C; Bap31/Bap29 cytoplasmic coiled-coil domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      156548911..156581002 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229556.5 → XP_006229618.1  B-cell receptor-associated protein 31 isoform X2

      See identical proteins and their annotated locations for XP_006229618.1

      UniProtKB/TrEMBL
      A0A0G2JXK2, A0A8I5ZTY8, Q6AY58
      Conserved Domains (2) summary
      pfam05529
      Location:1 → 136
      Bap31; B-cell receptor-associated protein 31-like
      pfam18035
      Location:192 → 245
      Bap31_Bap29_C; Bap31/Bap29 cytoplasmic coiled-coil domain

    2. XM_006229557.4 → XP_006229619.1  B-cell receptor-associated protein 31 isoform X2

      See identical proteins and their annotated locations for XP_006229619.1

      UniProtKB/TrEMBL
      A0A0G2JXK2, A0A8I5ZTY8, Q6AY58
      Conserved Domains (2) summary
      pfam05529
      Location:1 → 136
      Bap31; B-cell receptor-associated protein 31-like
      pfam18035
      Location:192 → 245
      Bap31_Bap29_C; Bap31/Bap29 cytoplasmic coiled-coil domain

    3. XM_063279836.1 → XP_063135906.1  B-cell receptor-associated protein 31 isoform X1

    4. XM_039099529.2 → XP_038955457.1  B-cell receptor-associated protein 31 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JXK2, A0A8I5ZTY8, Q6AY58
      Conserved Domains (2) summary
      pfam05529
      Location:1 → 136
      Bap31; B-cell receptor-associated protein 31-like
      pfam18035
      Location:192 → 245
      Bap31_Bap29_C; Bap31/Bap29 cytoplasmic coiled-coil domain
    Nucleotide Protein Strain
    Heading Accession and Version

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