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Snca synuclein alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 29219, updated on 3-Nov-2024

Summary

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Official Symbol: Sncaprovided by RGD
Official Full Name: synuclein alphaprovided by RGD
Primary source: RGD:3729
See related: EnsemblRapid:ENSRNOG00000008656 AllianceGenome:RGD:3729
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including phospholipase binding activity; phospholipid binding activity; and tubulin binding activity. Involved in several processes, including behavioral response to cocaine; negative regulation of dopamine metabolic process; and response to desipramine. Located in several cellular components, including cytoplasmic vesicle; distal axon; and mitochondrion. Used to study Parkinson's disease and amphetamine abuse. Biomarker of depressive disorder and neurilemmoma. Human ortholog(s) of this gene implicated in Alzheimer's disease; Lewy body dementia; Parkinson's disease; Parkinson's disease 1; and Parkinson's disease 4. Orthologous to human SNCA (synuclein alpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 542.3), Spleen (RPKM 92.9) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

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See Snca in Genome Data Viewer

Location:: 4q24

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (91026474..91127444, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (89696420..89797240, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (90782412..90883236, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mitophagy Upregulation Occurs Early in the Neurodegenerative Process Mediated by alpha-Synuclein.
Title: Mitophagy Upregulation Occurs Early in the Neurodegenerative Process Mediated by α-Synuclein.
Differential expression of alpha-synuclein in the hippocampus of SHR and SLA16 isogenic rat strains.
Title: Differential expression of alpha-synuclein in the hippocampus of SHR and SLA16 isogenic rat strains.
The toxicities of A30P and A53T alpha-synuclein fibrils can be uniquely altered by the length and saturation of fatty acids in phosphatidylserine.
Title: The toxicities of A30P and A53T α-synuclein fibrils can be uniquely altered by the length and saturation of fatty acids in phosphatidylserine.
Upregulation of Parkinson's disease-associated protein alpha-synuclein suppresses tumorigenesis via interaction with mGluR5 and gamma-synuclein in liver cancer.
Title: Upregulation of Parkinson's disease-associated protein alpha-synuclein suppresses tumorigenesis via interaction with mGluR5 and gamma-synuclein in liver cancer.
VPS35 and alpha-Synuclein fail to interact to modulate neurodegeneration in rodent models of Parkinson's disease.
Title: VPS35 and α-Synuclein fail to interact to modulate neurodegeneration in rodent models of Parkinson's disease.
Pathological convergence of APP and SNCA deficiency in hippocampal degeneration of young rats.
Title: Pathological convergence of APP and SNCA deficiency in hippocampal degeneration of young rats.
Intracellular Accumulation of alpha-Synuclein Aggregates Promotes S-Nitrosylation of MAP1A Leading to Decreased NMDAR-Evoked Calcium Influx and Loss of Mature Synaptic Spines.
Title: Intracellular Accumulation of α-Synuclein Aggregates Promotes S-Nitrosylation of MAP1A Leading to Decreased NMDAR-Evoked Calcium Influx and Loss of Mature Synaptic Spines.
alpha-synuclein buildup is alleviated via ESCRT-dependent endosomal degradation brought about by p38MAPK inhibition in cells expressing p25alpha.
Title: α-synuclein buildup is alleviated via ESCRT-dependent endosomal degradation brought about by p38MAPK inhibition in cells expressing p25α.
Lateralized deficits after unilateral AAV-vector based overexpression of alpha-synuclein in the midbrain of rats on drug-free behavioral tests.
Title: Lateralized deficits after unilateral AAV-vector based overexpression of alpha-synuclein in the midbrain of rats on drug-free behavioral tests.
Pathogenic Mechanisms of Cytosolic and Membrane-Enriched alpha-Synuclein Converge on Fatty Acid Homeostasis.
Title: Pathogenic Mechanisms of Cytosolic and Membrane-Enriched α-Synuclein Converge on Fatty Acid Homeostasis.

Submit: New GeneRIF Correction See all GeneRIFs (160)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Snca (e-PCR), detects polymorphism
- UniSTS:234028

UniSTS:234029 (e-PCR)
- UniSTS:234029

Snca (e-PCR), detects polymorphism
- UniSTS:234029

PMC153617P1 (e-PCR)
- UniSTS:271263

PMC153617P2 (e-PCR)
- UniSTS:271264

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Hsp70 protein binding	IEA Inferred from Electronic Annotation more info
enables Hsp70 protein binding	ISO Inferred from Sequence Orthology more info
enables SNARE binding	IEA Inferred from Electronic Annotation more info
enables SNARE binding	ISO Inferred from Sequence Orthology more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables alpha-tubulin binding	IEA Inferred from Electronic Annotation more info
enables alpha-tubulin binding	ISO Inferred from Sequence Orthology more info
enables arachidonate binding	ISO Inferred from Sequence Orthology more info
enables beta-tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables copper ion binding	ISO Inferred from Sequence Orthology more info
enables copper ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables cuprous ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables cuprous ion binding	IEA Inferred from Electronic Annotation more info
enables cuprous ion binding	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
enables dynein complex binding	IEA Inferred from Electronic Annotation more info
enables dynein complex binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
NOT enables fatty acid binding	ISO Inferred from Sequence Orthology more info
enables ferrous iron binding	IEA Inferred from Electronic Annotation more info
enables ferrous iron binding	ISO Inferred from Sequence Orthology more info
enables histone binding	IEA Inferred from Electronic Annotation more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables kinesin binding	IEA Inferred from Electronic Annotation more info
enables kinesin binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	ISO Inferred from Sequence Orthology more info
NOT enables phospholipase D inhibitor activity	ISO Inferred from Sequence Orthology more info
enables phospholipase binding	IPI Inferred from Physical Interaction more info	PubMed
enables phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
enables phospholipid binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info
enables phosphoprotein binding	IEA Inferred from Electronic Annotation more info
enables phosphoprotein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables tau protein binding	IEA Inferred from Electronic Annotation more info
enables tau protein binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in SNARE complex assembly	IEA Inferred from Electronic Annotation more info
involved_in SNARE complex assembly	ISO Inferred from Sequence Orthology more info
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adult locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in amyloid fibril formation	ISO Inferred from Sequence Orthology more info
involved_in behavioral response to cocaine	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to copper ion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to copper ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to fibroblast growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dopamine biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dopamine metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within membrane organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within microglial cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrial ATP synthesis coupled electron transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrial membrane organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chaperone-mediated autophagy	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of chaperone-mediated autophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of dopamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of dopamine uptake involved in synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of dopamine uptake involved in synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of exocytosis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of exocytosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microtubule polymerization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of monooxygenase activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of monooxygenase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of norepinephrine uptake	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of norepinephrine uptake	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of platelet-derived growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of serotonin uptake	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of serotonin uptake	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of thrombin-activated receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of thrombin-activated receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transporter activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transporter activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neutral lipid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phospholipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of SNARE complex assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of SNARE complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of exocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of exocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glutathione peroxidase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glutathione peroxidase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hydrogen peroxide catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of hydrogen peroxide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of inositol phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to cell periphery	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to cell periphery	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor recycling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of receptor recycling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in protein complex oligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein destabilization	IEA Inferred from Electronic Annotation more info
involved_in protein destabilization	ISO Inferred from Sequence Orthology more info
involved_in protein tetramerization	IEA Inferred from Electronic Annotation more info
involved_in protein tetramerization	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of acyl-CoA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of dopamine secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of dopamine secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of glutamate secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of locomotion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of macrophage activation	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of norepinephrine uptake	ISO Inferred from Sequence Orthology more info
involved_in regulation of phospholipase activity	IEA Inferred from Electronic Annotation more info
involved_in regulation of phospholipase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynapse assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynapse assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
involved_in regulation of transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
involved_in response to cocaine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to desipramine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to interleukin-1	IEA Inferred from Electronic Annotation more info
involved_in response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in response to iron(II) ion	IEA Inferred from Electronic Annotation more info
involved_in response to iron(II) ion	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to magnesium ion	IEA Inferred from Electronic Annotation more info
involved_in response to magnesium ion	ISO Inferred from Sequence Orthology more info
involved_in response to type II interferon	IEA Inferred from Electronic Annotation more info
involved_in response to type II interferon	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in synapse organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within synapse organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synaptic transmission, dopaminergic	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle priming	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle priming	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synaptic vesicle transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in axon terminus	IBA Inferred from Biological aspect of Ancestor more info
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in inclusion body	IEA Inferred from Electronic Annotation more info
located_in inclusion body	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nuclear outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in platelet alpha granule membrane	IEA Inferred from Electronic Annotation more info
located_in platelet alpha granule membrane	ISO Inferred from Sequence Orthology more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
located_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IEA Inferred from Electronic Annotation more info
located_in presynapse	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in ribosome	IDA Inferred from Direct Assay more info	PubMed
located_in supramolecular fiber	IEA Inferred from Electronic Annotation more info
located_in supramolecular fiber	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	HDA more info	PubMed
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: alpha-synuclein

Names: synuclein, alpha (non A4 component of amyloid precursor)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.