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    Ly86 lymphocyte antigen 86 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291359, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ly86provided by RGD
    Official Full Name
    lymphocyte antigen 86provided by RGD
    Primary source
    RGD:1309936
    See related
    EnsemblRapid:ENSRNOG00000000137 AllianceGenome:RGD:1309936
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in innate immune response and positive regulation of lipopolysaccharide-mediated signaling pathway. Orthologous to human LY86 (lymphocyte antigen 86). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 194.9), Thymus (RPKM 52.3) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ly86 in Genome Data Viewer
    Location:
    17p12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (27621313..27705336, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (27415807..27499695, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (28104535..28191447, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene triosephosphate isomerase 1 like 2 Neighboring gene U1 spliceosomal RNA Neighboring gene uncharacterized LOC120097796 Neighboring gene uncharacterized LOC100910628 Neighboring gene D-3-phosphoglycerate dehydrogenase-like Neighboring gene coagulation factor XIII A1 chain Neighboring gene enolase 1, pseudogene 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells. Ogata H, et al. J Exp Med, 2000 Jul 3. PMID 10880523, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of lipopolysaccharide-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of lipopolysaccharide-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of lipopolysaccharide-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    lymphocyte antigen 86

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106128.1 → NP_001099598.1  lymphocyte antigen 86

      See identical proteins and their annotated locations for NP_001099598.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473977
      UniProtKB/TrEMBL
      A6J7C7, D3ZAS0
      Related
      ENSRNOP00000000149.5, ENSRNOT00000000149.8
      Conserved Domains (1) summary
      cl00274
      Location:55 → 184
      ML; The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, Niemann-Pick type C2 (Npc2) protein, phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP), mite allergen Der p 2 and several proteins of ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      27621313..27705336 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253800.5 → XP_006253862.1  lymphocyte antigen 86 isoform X1

      See identical proteins and their annotated locations for XP_006253862.1

      UniProtKB/TrEMBL
      A6J7C7, D3ZAS0
      Conserved Domains (1) summary
      cl00274
      Location:55 → 184
      ML; The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, Niemann-Pick type C2 (Npc2) protein, phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP), mite allergen Der p 2 and several proteins of ...
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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