Eci2 enoyl-CoA delta isomerase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eci2provided by RGD
Official Full Name: enoyl-CoA delta isomerase 2provided by RGD
Primary source: RGD:1359427
See related: EnsemblRapid:ENSRNOG00000066714 AllianceGenome:RGD:1359427
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Peci
Summary: Enables delta(3)-delta(2)-enoyl-CoA isomerase activity. Involved in fatty acid beta-oxidation. Located in peroxisome. Orthologous to human ECI2 (enoyl-CoA delta isomerase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 875.7), Heart (RPKM 764.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (30056274..30092169)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (29850884..29886781)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (30556926..30573324)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH134397 (e-PCR)
- UniSTS:217679

BG376613 (e-PCR)
- UniSTS:243939

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables delta(3)-delta(2)-enoyl-CoA isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables delta(3)-delta(2)-enoyl-CoA isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables delta(3)-delta(2)-enoyl-CoA isomerase activity	IEA Inferred from Electronic Annotation more info
enables delta(3)-delta(2)-enoyl-CoA isomerase activity	ISO Inferred from Sequence Orthology more info
enables fatty-acyl-CoA binding	IEA Inferred from Electronic Annotation more info
enables intramolecular oxidoreductase activity, transposing C=C bonds	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid beta-oxidation	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info
involved_in fatty acid catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in peroxisomal matrix	IEA Inferred from Electronic Annotation more info
located_in peroxisomal matrix	ISO Inferred from Sequence Orthology more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: enoyl-CoA delta isomerase 2

Names: D3,D2-enoyl-CoA isomerase; delta(3),delta(2)-enoyl-CoA isomerase; dodecenoyl-CoA isomerase; enoyl-CoA delta isomerase 2, mitochondrial; enoyl-Coenzyme A delta isomerase 2; peroxisomal 3,2-trans-enoyl-CoA isomerase; peroxisomal D3,D2-enoyl-CoA isomerase; peroxisomal delta3, delta2-enoyl-Coenzyme A isomerase

NP_001006967.1

EC 5.3.3.8

XP_038951410.1

EC 5.3.3.8

XP_038951411.1

EC 5.3.3.8

XP_038951412.1

EC 5.3.3.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001006966.1 → NP_001006967.1 enoyl-CoA delta isomerase 2 precursor

See identical proteins and their annotated locations for NP_001006967.1

Status: PROVISIONAL

Source sequence(s)

BC083764

UniProtKB/Swiss-Prot

Q5XIC0

Conserved Domains (2) summary

pfam00887
Location:38 → 113

ACBP; Acyl CoA binding protein

cl23717
Location:134 → 389

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

30056274..30092169

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039095482.1 → XP_038951410.1 enoyl-CoA delta isomerase 2 isoform X1

UniProtKB/TrEMBL

A0A8L2QBE2, A6J7E6

Related

ENSRNOP00000022022.4, ENSRNOT00000022022.8

Conserved Domains (2) summary

pfam00887
Location:5 → 80

ACBP; Acyl CoA binding protein

cl23717
Location:101 → 356

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
XM_039095484.2 → XP_038951412.1 enoyl-CoA delta isomerase 2 isoform X1

UniProtKB/TrEMBL

A0A8L2QBE2, A6J7E6

Conserved Domains (2) summary

pfam00887
Location:5 → 80

ACBP; Acyl CoA binding protein

cl23717
Location:101 → 356

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
XM_039095483.2 → XP_038951411.1 enoyl-CoA delta isomerase 2 isoform X1

UniProtKB/TrEMBL

A0A8L2QBE2, A6J7E6

Conserved Domains (2) summary

pfam00887
Location:5 → 80

ACBP; Acyl CoA binding protein

cl23717
Location:101 → 356

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...