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    Adam9 ADAM metallopeptidase domain 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290834, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Adam9provided by RGD
    Official Full Name
    ADAM metallopeptidase domain 9provided by RGD
    Primary source
    RGD:621473
    See related
    EnsemblRapid:ENSRNOG00000017231 AllianceGenome:RGD:621473
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MDC9
    Summary
    Predicted to enable several functions, including SH3 domain binding activity; metalloendopeptidase activity involved in amyloid precursor protein catabolic process; and protein kinase C binding activity. Involved in response to antineoplastic agent and response to laminar fluid shear stress. Located in basolateral plasma membrane and cell surface. Biomarker of Alzheimer's disease and status epilepticus. Human ortholog(s) of this gene implicated in cone-rod dystrophy 9. Orthologous to human ADAM9 (ADAM metallopeptidase domain 9). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 255.8), Lung (RPKM 241.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adam9 in Genome Data Viewer
    Location:
    16q12.4
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (73725186..73804284)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (67022538..67101647)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (71810377..71887926)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene HtrA serine peptidase 4 Neighboring gene TM2 domain containing 2 Neighboring gene U6 spliceosomal RNA Neighboring gene ADAM metallopeptidase domain 32 Neighboring gene ADAM metallopeptidase domain 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification, cellular distribution and potential function of the metalloprotease-disintegrin MDC9 in the kidney. Mahimkar RM, et al. J Am Soc Nephrol, 2000 Apr. PMID 10752518
    2. Low blood flow after angioplasty augments mechanisms of restenosis: inward vessel remodeling, cell migration, and activity of genes regulating migration. Ward MR, et al. Arterioscler Thromb Vasc Biol, 2001 Feb. PMID 11156854
    3. ADAM9 expression in pancreatic cancer is associated with tumour type and is a prognostic factor in ductal adenocarcinoma. Grützmann R, et al. Br J Cancer, 2004 Mar 8. PMID 14997207, Free PMC Article
    4. Expression of ADAM9 in CIN3 lesions and squamous cell carcinomas of the cervix. Zubel A, et al. Gynecol Oncol, 2009 Aug. PMID 19473694
    5. ADAM9 is involved in pathological retinal neovascularization. Guaiquil V, et al. Mol Cell Biol, 2009 May. PMID 19273593, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables collagen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables laminin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in amyloid precursor protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell-cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane protein ectodomain proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within membrane protein intracellular domain proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monocyte activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of keratinocyte migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of macrophage fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to antineoplastic agent IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to glucocorticoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to laminar fluid shear stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to manganese ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 9
    Names
    a disintegrin and metallopeptidase domain 9 (meltrin gamma)
    a disintegrin and metalloproteinase domain 9 (meltrin gamma)
    meltrin gamma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014772.2 → NP_001014772.2  disintegrin and metalloproteinase domain-containing protein 9 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      E9PTA4, Q58GH6
      Related
      ENSRNOP00000102349.1, ENSRNOT00000168882.1
      Conserved Domains (6) summary
      smart00050
      Location:423 → 498
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:500 → 636
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:212 → 406
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:44 → 163
      Pep_M12B_propep; Reprolysin family propeptide
      pfam07974
      Location:650 → 673
      EGF_2; EGF-like domain
      pfam15240
      Location:732 → 802
      Pro-rich; Proline-rich

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      73725186..73804284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275248.1 → XP_063131318.1  disintegrin and metalloproteinase domain-containing protein 9 isoform X1

    2. XM_039094403.2 → XP_038950331.1  disintegrin and metalloproteinase domain-containing protein 9 isoform X2

      UniProtKB/TrEMBL
      Q58GH6
      Related
      ENSRNOP00000089910.2, ENSRNOT00000120151.2
      Conserved Domains (6) summary
      smart00050
      Location:423 → 498
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:500 → 636
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:212 → 406
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:44 → 163
      Pep_M12B_propep; Reprolysin family propeptide
      pfam06346
      Location:747 → 793
      Drf_FH1; Formin Homology Region 1
      pfam07974
      Location:650 → 673
      EGF_2; EGF-like domain

    3. XM_063275249.1 → XP_063131319.1  disintegrin and metalloproteinase domain-containing protein 9 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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