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    Klhl1 kelch-like family member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290426, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Klhl1provided by RGD
    Official Full Name
    kelch-like family member 1provided by RGD
    Primary source
    RGD:1307452
    See related
    EnsemblRapid:ENSRNOG00000031100 AllianceGenome:RGD:1307452
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to act upstream of or within adult walking behavior; cerebellar Purkinje cell layer development; and dendrite development. Predicted to be located in cytoplasm; dendrite; and neuronal cell body. Orthologous to human KLHL1 (kelch like family member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 23.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Klhl1 in Genome Data Viewer
    Location:
    15q21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (79106164..79550684, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (72698191..73142726, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (80270846..80714176, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene AFG3 (ATPase family gene 3)-like 1, pseudogene 1 Neighboring gene A-kinase interacting protein 1, pseudogene 1 Neighboring gene U6 spliceosomal RNA Neighboring gene SNRPN upstream reading frame protein-like Neighboring gene peptidylprolyl isomerase A like 4G Neighboring gene small nuclear ribonucleoprotein polypeptide N like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Process elongation of oligodendrocytes is promoted by the Kelch-related protein MRP2/KLHL1. Jiang S, et al. J Biol Chem, 2007 Apr 20. PMID 17324934
    2. Targeted deletion of a single Sca8 ataxia locus allele in mice causes abnormal gait, progressive loss of motor coordination, and Purkinje cell dendritic deficits. He Y, et al. J Neurosci, 2006 Sep 27. PMID 17005861, Free PMC Article
    3. KLHL1/MRP2 mediates neurite outgrowth in a glycogen synthase kinase 3beta-dependent manner. Seng S, et al. Mol Cell Biol, 2006 Nov. PMID 16982692, Free PMC Article
    4. The SCA8 transcript is an antisense RNA to a brain-specific transcript encoding a novel actin-binding protein (KLHL1). Nemes JP, et al. Hum Mol Genet, 2000 Jun 12. PMID 10888605
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study provides, for the first time, insights into the involvement of MRP2 in neurite outgrowth, which occurs in a GSK3beta-dependent manner.
      Title: KLHL1/MRP2 mediates neurite outgrowth in a glycogen synthase kinase 3beta-dependent manner.
    2. MRP2/KLHL1 has a role, through its interaction with actin, in the process elongation of oligodendrocytes
      Title: Process elongation of oligodendrocytes is promoted by the Kelch-related protein MRP2/KLHL1.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within adult walking behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cerebellar Purkinje cell layer development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within dendrite development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 1
    Names
    kelch-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394673.2 → NP_001381602.1  kelch-like protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I6G933
      Related
      ENSRNOP00000061127.2, ENSRNOT00000063800.3
      Conserved Domains (2) summary
      PHA03098
      Location:208 → 730
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:498 → 541
      Kelch; KELCH repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      79106164..79550684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106054.1: Suppressed sequence

      Description
      NM_001106054.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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