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    Oxsm 3-oxoacyl-ACP synthase, mitochondrial [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289934, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Oxsmprovided by RGD
    Official Full Name
    3-oxoacyl-ACP synthase, mitochondrialprovided by RGD
    Primary source
    RGD:1311092
    See related
    AllianceGenome:RGD:1311092
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311092
    Summary
    Predicted to enable 3-oxoacyl-[acyl-carrier-protein] synthase activity. Predicted to be involved in acyl-CoA metabolic process; medium-chain fatty acid biosynthetic process; and short-chain fatty acid biosynthetic process. Predicted to be located in cytosol and mitochondrion. Orthologous to human OXSM (3-oxoacyl-ACP synthase, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 26.9), Kidney (RPKM 22.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Oxsm in Genome Data Viewer
    Location:
    15p16
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (11641177..11645370)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (9210443..9215852)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (10462380..10466496)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene DNA topoisomerase II beta Neighboring gene N-glycanase 1 Neighboring gene uncharacterized LOC120097102 Neighboring gene uncharacterized LOC134481945

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning, expression, and characterization of the human mitochondrial beta-ketoacyl synthase. Complementation of the yeast CEM1 knock-out strain. Zhang L, et al. J Biol Chem, 2005 Apr 1. PMID 15668256
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-oxoacyl-[acyl-carrier-protein] synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in medium-chain fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in short-chain fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
    NP_001093978.1
    XP_006251773.1
    XP_038949017.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100508.1 → NP_001093978.1  3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial

      See identical proteins and their annotated locations for NP_001093978.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6K049, G3V6R7
      Conserved Domains (1) summary
      cl09938
      Location:38 → 451
      cond_enzymes; Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      11641177..11645370
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093089.2 → XP_038949017.1  3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A6K049, G3V6R7
      Conserved Domains (1) summary
      cl09938
      Location:38 → 451
      cond_enzymes; Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the ...

    2. XM_006251711.4 → XP_006251773.1  3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006251773.1

      UniProtKB/TrEMBL
      A6K049, G3V6R7
      Conserved Domains (1) summary
      cl09938
      Location:38 → 451
      cond_enzymes; Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the ...
    Nucleotide Protein Strain
    Heading Accession and Version

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