Kpna1 karyopherin subunit alpha 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kpna1provided by RGD
Official Full Name: karyopherin subunit alpha 1provided by RGD
Primary source: RGD:735064
See related: EnsemblRapid:ENSRNOG00000051711 AllianceGenome:RGD:735064
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables nuclear localization sequence binding activity. Involved in NLS-bearing protein import into nucleus and postsynapse to nucleus signaling pathway. Located in dendrite and nucleus. Orthologous to human KPNA1 (karyopherin subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 430.4), Heart (RPKM 285.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q22

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (78221165..78279778, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (64715844..64774647, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (67652573..67717180, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest involvement of KPNA1 in the striatal responses to denervation following 6-hydroxydopamine (6-OHDA)-induced lesion.
Title: Molecular cloning and characterization of rat karyopherin alpha 1 gene: structure and expression.
PTH1R forms a complex with the transport regulatory proteins, importin alpha(1) and importin beta, and nuclear PTH1R is associated with the nucleoplasm
Title: Type 1 parathyroid hormone receptor (PTH1R) nuclear trafficking: association of PTH1R with importin alpha1 and beta.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Kpna1 (e-PCR), detects polymorphism
- UniSTS:143720

BE113307 (e-PCR)
- UniSTS:246653

AA800028 (e-PCR)
- UniSTS:261275

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables nuclear import signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear import signal receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear import signal receptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear localization sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear localization sequence binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in NLS-bearing protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in NLS-bearing protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in NLS-bearing protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within NLS-bearing protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in NLS-bearing protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in postsynapse to nucleus signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in postsynapse to nucleus signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in postsynapse to nucleus signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in satellite cell activation involved in skeletal muscle regeneration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within satellite cell activation involved in skeletal muscle regeneration	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle satellite cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal muscle satellite cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle tissue regeneration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of NLS-dependent protein nuclear import complex	IEA Inferred from Electronic Annotation more info
part_of NLS-dependent protein nuclear import complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: importin subunit alpha-5

Names: importin alpha-5; importin subunit alpha-1; karyopherin alpha 1; karyopherin/importin alpha-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198726.2 → NP_942021.2 importin subunit alpha-5

See identical proteins and their annotated locations for NP_942021.2

Status: PROVISIONAL

Source sequence(s)

AY779025

UniProtKB/Swiss-Prot

P83953

UniProtKB/TrEMBL

A0A0G2JXY5, Q56R20

Conserved Domains (2) summary

COG5064
Location:33 → 516

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:128 → 154

ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

78221165..78279778 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039088121.2 → XP_038944049.1 importin subunit alpha-5 isoform X1

UniProtKB/Swiss-Prot

P83953

UniProtKB/TrEMBL

A0A0G2JXY5, Q56R20

Related

ENSRNOP00000071569.2, ENSRNOT00000078285.3

Conserved Domains (2) summary

COG5064
Location:33 → 516

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:128 → 154

ARM; armadillo repeat [structural motif]
XM_017597922.3 → XP_017453411.1 importin subunit alpha-5 isoform X1

UniProtKB/Swiss-Prot

P83953

UniProtKB/TrEMBL

A0A0G2JXY5, Q56R20

Conserved Domains (2) summary

COG5064
Location:33 → 516

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:128 → 154

ARM; armadillo repeat [structural motif]
XM_039088122.2 → XP_038944050.1 importin subunit alpha-5 isoform X2

Conserved Domains (2) summary

COG5064
Location:1 → 315

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:172 → 208

ARM; armadillo repeat [structural motif]