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    Map2k4 mitogen activated protein kinase kinase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287398, updated on 10-Oct-2024

    Summary

    Official Symbol
    Map2k4provided by RGD
    Official Full Name
    mitogen activated protein kinase kinase 4provided by RGD
    Primary source
    RGD:1307040
    See related
    EnsemblRapid:ENSRNOG00000003834 AllianceGenome:RGD:1307040
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MKK4; Sek1
    Summary
    Enables ATP binding activity; JUN kinase kinase activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including cellular response to sorbitol; positive regulation of JNK cascade; and positive regulation of macromolecule metabolic process. Located in several cellular components, including axon; dendrite cytoplasm; and perikaryon. Used to study transient cerebral ischemia. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian serous carcinoma; pancreatic cancer; respiratory system cancer (multiple); and urinary bladder cancer. Orthologous to human MAP2K4 (mitogen-activated protein kinase kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 321.5), Muscle (RPKM 175.2) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Map2k4 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (50842348..50947063, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (50343227..50447956, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (52196121..52301887, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095121 Neighboring gene myocardin Neighboring gene uncharacterized LOC102554159 Neighboring gene THAP domain-containing protein 5-like Neighboring gene zinc finger protein 18 Neighboring gene dynein, axonemal, heavy chain 9 Neighboring gene uncharacterized LOC120095122

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables JUN kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables JUN kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables MAP kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell growth involved in cardiac muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to sorbitol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of motor neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of nitric-oxide synthase biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to wounding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in smooth muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dual specificity mitogen-activated protein kinase kinase 4
    Names
    MAP2K4delta
    SAPK/ERK kinase 1
    NP_001025194.1
    XP_038941354.1
    XP_063124696.1
    XP_063124697.1
    XP_063124698.1
    XP_063124699.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030023.2NP_001025194.1  dual specificity mitogen-activated protein kinase kinase 4

      See identical proteins and their annotated locations for NP_001025194.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      F1LP57, Q4KSH6
      Related
      ENSRNOP00000081371.2, ENSRNOT00000109134.2
      Conserved Domains (1) summary
      cd06616
      Location:93383
      PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      50842348..50947063 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085426.2XP_038941354.1  dual specificity mitogen-activated protein kinase kinase 4 isoform X3

      UniProtKB/TrEMBL
      F1LP57, S4VP54
      Related
      ENSRNOP00000095727.1, ENSRNOT00000112493.2
      Conserved Domains (1) summary
      cd06616
      Location:104394
      PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4
    2. XM_063268626.1XP_063124696.1  dual specificity mitogen-activated protein kinase kinase 4 isoform X1

    3. XM_063268627.1XP_063124697.1  dual specificity mitogen-activated protein kinase kinase 4 isoform X2

      Related
      ENSRNOP00000102620.1, ENSRNOT00000141706.1
    4. XM_063268629.1XP_063124699.1  dual specificity mitogen-activated protein kinase kinase 4 isoform X5

    5. XM_063268628.1XP_063124698.1  dual specificity mitogen-activated protein kinase kinase 4 isoform X4