Flii FLII, actin remodeling protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fliiprovided by RGD
Official Full Name: FLII, actin remodeling proteinprovided by RGD
Primary source: RGD:1307590
See related: EnsemblRapid:ENSRNOG00000004159 AllianceGenome:RGD:1307590
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fliih
Summary: Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in actin cytoskeleton organization; actin filament severing; and barbed-end actin filament capping. Predicted to be located in several cellular components, including brush border; centriolar satellite; and nucleoplasm. Predicted to be active in actin cytoskeleton; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human FLII (FLII actin remodeling protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 341.5), Heart (RPKM 328.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (45893566..45907547, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (45394032..45408051, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (46955460..46969468, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Decreased expression of Flightless I in early-gestation fetal wounds improves healing.
Title: Decreased expression of Flightless I, a gelsolin family member and developmental regulator, in early-gestation fetal wounds improves healing.
Flii appears to have a positive role in the regeneration of hair follicles, contrary to its negative influence on wound healing in skin
Title: Regeneration of hair follicles is modulated by flightless I (Flii) in a rodent vibrissa model.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH128713 (e-PCR)
- UniSTS:212021

RH133887 (e-PCR)
- UniSTS:217170

RH129564 (e-PCR)
- UniSTS:212866

D10Rat83 (e-PCR)
- UniSTS:118211

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-4,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament severing	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin polymerization or depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in barbed-end actin filament capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in myofibril assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in sarcomere organization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in podosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein flightless-1 homolog

Names: flightless I actin binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008279.1 → NP_001008280.1 protein flightless-1 homolog

See identical proteins and their annotated locations for NP_001008280.1

Status: PROVISIONAL

Source sequence(s)

BC085829

UniProtKB/TrEMBL

Q5RKI5

Related

ENSRNOP00000006753.6, ENSRNOT00000006753.7

Conserved Domains (8) summary

cd11280
Location:619 → 703

gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins

cd11288
Location:1054 → 1153

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:492 → 604

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:1164 → 1263

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:723 → 837

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd00116
Location:89 → 375

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:106 → 128

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:131 → 186

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

45893566..45907547 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006246468.5 → XP_006246530.1 protein flightless-1 homolog isoform X1

UniProtKB/TrEMBL

F7F0E5

Conserved Domains (8) summary

cd11280
Location:618 → 702

gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins

cd11288
Location:1053 → 1152

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:491 → 603

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:1163 → 1262

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:722 → 836

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd00116
Location:89 → 375

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:106 → 128

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:131 → 186

LRR_8; Leucine rich repeat