Trpc7 transient receptor potential cation channel, subfamily C, member 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trpc7provided by RGD
Official Full Name: transient receptor potential cation channel, subfamily C, member 7provided by RGD
Primary source: RGD:628820
See related: EnsemblRapid:ENSRNOG00000012727 AllianceGenome:RGD:628820
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable inositol 1,4,5 trisphosphate binding activity and store-operated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport; regulation of cytosolic calcium ion concentration; and single fertilization. Located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human TRPC7 (transient receptor potential cation channel subfamily C member 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 10.1), Lung (RPKM 6.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (7707954..7839064)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (7708911..7833435)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (8134267..8280360)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In cardiomyocytes, activation of P2Y(2) receptors, via a G protein and stimulation of PLCbeta, induces the opening of heteromeric TRPC3/7 channels, leading to a sustained, nonspecific cationic current.
Title: ATP/UTP activate cation-permeable channels with TRPC3/7 properties in rat cardiomyocytes.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB254000 (e-PCR)
- UniSTS:208939

RH140173 (e-PCR)
- UniSTS:222252

Trpc7 (e-PCR), detects polymorphism
- UniSTS:516718

RH129314 (e-PCR)
- UniSTS:212621

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables inositol 1,4,5 trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables monoatomic cation channel activity	TAS Traceable Author Statement more info	PubMed
enables store-operated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in manganese ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in single fertilization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of cation channel complex	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: short transient receptor potential channel 7

Names: capacitative calcium channel TRPC7

NP_001178620.2

EC 3.6.1.13

XP_017455952.1

EC 3.6.1.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191691.3 → NP_001178620.2 short transient receptor potential channel 7

See identical proteins and their annotated locations for NP_001178620.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A0A8I6GIE6, A6KAM1, F1LQF7

Related

ENSRNOP00000016982.5, ENSRNOT00000016982.6

Conserved Domains (5) summary

cd00204
Location:51 → 184

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

TIGR00870
Location:27 → 822

trp; transient-receptor-potential calcium channel protein

pfam08344
Location:198 → 256

TRP_2; Transient receptor ion channel II

sd00045
Location:77 → 108

ANK; ANK repeat [structural motif]

cl00511
Location:582 → 665

FTSW_RODA_SPOVE; Cell cycle protein