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    BTN1A1 butyrophilin subfamily 1 member A1 [ Bos taurus (domestic cattle) ]

    Gene ID: 282157, updated on 4-Oct-2024

    Summary

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    Official Symbol
    BTN1A1provided by VGNC
    Official Full Name
    butyrophilin subfamily 1 member A1provided by VGNC
    Primary source
    VGNC:VGNC:107283
    See related
    Ensembl:ENSBTAG00000031753
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    BT; BTN
    Orthologs
    human mouse all
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    Genomic context

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    See BTN1A1 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (31585155..31592119, complement)

    Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene transfer RNA threonine (anticodon AGU) Neighboring gene transfer RNA leucine (anticodon CAG) Neighboring gene uncharacterized LOC104975682 Neighboring gene butyrophilin subfamily 2 member A2 Neighboring gene butyrophilin subfamily 3 member A2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High resolution melt curve analysis identifies a novel SNP (G21A) in butyrophilin gene having significant association with milk production traits in Holstein Friesian crossbreds of Kerala. Potu H, et al. Anim Biotechnol, 2023 Nov. PMID 35189067
    2. Variability of milk fat globule membrane protein gene between cattle and riverine buffalo. Bhattacharya TK, et al. DNA Seq, 2004 Oct-Dec. PMID 15621656
    3. Structure and sequence of the bovine butyrophilin gene. Davey HW, et al. Gene, 1997 Oct 15. PMID 9358039
    4. Cloning and analysis of cDNA encoding bovine butyrophilin, an apical glycoprotein expressed in mammary tissue and secreted in association with the milk-fat globule membrane during lactation. Jack LJ, et al. J Biol Chem, 1990 Aug 25. PMID 2387867
    5. Antibody cross-reactivity between myelin oligodendrocyte glycoprotein and the milk protein butyrophilin in multiple sclerosis. Guggenmos J, et al. J Immunol, 2004 Jan 1. PMID 14688379

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. High resolution melt curve analysis identifies a novel SNP (G21A) in butyrophilin gene having significant association with milk production traits in Holstein Friesian crossbreds of Kerala.
      Title: High resolution melt curve analysis identifies a novel SNP (G21A) in butyrophilin gene having significant association with milk production traits in Holstein Friesian crossbreds of Kerala.
    2. BTN present in milk and dairy products may influence the composition and function of myelin oligodendrocyte glycoprotein (MOG)-specific autoimmune repertoire during the course of multiple sclerosis.
      Title: Antibody cross-reactivity between myelin oligodendrocyte glycoprotein and the milk protein butyrophilin in multiple sclerosis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cytokine production IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    butyrophilin subfamily 1 member A1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174508.2 → NP_776933.1  butyrophilin subfamily 1 member A1 precursor

      See identical proteins and their annotated locations for NP_776933.1

      Status: PROVISIONAL

      Source sequence(s)
      M35551
      UniProtKB/Swiss-Prot
      O18955, O18959, O46535, P18892, Q6RUS3
      Related
      ENSBTAP00000042450.4, ENSBTAT00000045021.4
      Conserved Domains (4) summary
      cd05713
      Location:43 → 142
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:35 → 141
      IG_like; Immunoglobulin like
      cd15819
      Location:302 → 473
      SPRY_PRY_BTN1_2; butyrophilin subfamily member A1 and A2 (BTN1A and BTN2A)
      cl11960
      Location:161 → 223
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      31585155..31592119 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024983385.2 → XP_024839153.1  butyrophilin subfamily 1 member A1 isoform X1

      UniProtKB/Swiss-Prot
      O18955, O18959, O46535, P18892, Q6RUS3
      UniProtKB/TrEMBL
      F1MZQ4
      Conserved Domains (3) summary
      cd15819
      Location:302 → 473
      SPRY_PRY_BTN1_2; butyrophilin subfamily member A1 and A2 (BTN1A and BTN2A)
      cd05713
      Location:43 → 142
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      cl11960
      Location:161 → 223
      Ig; Immunoglobulin domain

    2. XM_024983386.2 → XP_024839154.1  butyrophilin subfamily 1 member A1 isoform X1

      UniProtKB/Swiss-Prot
      O18955, O18959, O46535, P18892, Q6RUS3
      UniProtKB/TrEMBL
      F1MZQ4
      Conserved Domains (3) summary
      cd15819
      Location:302 → 473
      SPRY_PRY_BTN1_2; butyrophilin subfamily member A1 and A2 (BTN1A and BTN2A)
      cd05713
      Location:43 → 142
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      cl11960
      Location:161 → 223
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18892.2 GenPept UniProtKB/Swiss-Prot:P18892

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials