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    VLDLR very low density lipoprotein receptor [ Bos taurus (domestic cattle) ]

    Gene ID: 282123, updated on 4-Oct-2024

    Summary

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    Official Symbol
    VLDLRprovided by VGNC
    Official Full Name
    very low density lipoprotein receptorprovided by VGNC
    Primary source
    VGNC:VGNC:36803
    See related
    BGD:BT22854; Ensembl:ENSBTAG00000018517
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See VLDLR in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (41828344..41859824, complement)

    Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132345950 Neighboring gene potassium voltage-gated channel modifier subfamily V member 2 Neighboring gene uncharacterized LOC132345949 Neighboring gene uncharacterized LOC132345951 Neighboring gene disks large-associated protein 1-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of O-linked sugars in determining the very low density lipoprotein receptor stability or release from the cell. Magrané J, et al. FEBS Lett, 1999 May 14. PMID 10356983
    2. Bovine aortic endothelial cells express a variant of the very low density lipoprotein receptor that lacks the O-linked sugar domain. Magrané J, et al. J Lipid Res, 1998 Nov. PMID 9799803
    3. Expression of mRNA of lipoprotein receptor related protein 8, low density lipoprotein receptor, and very low density lipoprotein receptor in bovine ovarian cells during follicular development and corpus luteum formation and regression. Argov N, et al. Mol Reprod Dev, 2004 Jun. PMID 15095337
    4. Lipid transport in the developing bovine follicle: messenger RNA expression increases for selective uptake receptors and decreases for endocytosis receptors. Argov N, et al. Biol Reprod, 2004 Aug. PMID 15056566
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    very low-density lipoprotein receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174489.2 → NP_776914.1  very low-density lipoprotein receptor precursor

      See identical proteins and their annotated locations for NP_776914.1

      Status: VALIDATED

      Source sequence(s)
      AF016537
      UniProtKB/TrEMBL
      A0A3Q1M7D4, O77505
      Related
      ENSBTAP00000065005.2, ENSBTAT00000067046.2
      Conserved Domains (8) summary
      smart00192
      Location:71 → 103
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:505 → 547
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:396 → 426
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:33 → 67
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:237 → 273
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:568 → 608
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:360 → 394
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00104
      Location:320 → 350
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      41828344..41859824 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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