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    IL2RA interleukin 2 receptor subunit alpha [ Bos taurus (domestic cattle) ]

    Gene ID: 281861, updated on 4-Oct-2024

    Summary

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    Official Symbol
    IL2RAprovided by VGNC
    Official Full Name
    interleukin 2 receptor subunit alphaprovided by VGNC
    Primary source
    VGNC:VGNC:56188
    See related
    Ensembl:ENSBTAG00000020892
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    CD25
    Orthologs
    human mouse all
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    Genomic context

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    See IL2RA in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (17455219..17500715)

    Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112449256 Neighboring gene RNA binding motif protein 17 Neighboring gene interleukin 15 receptor subunit alpha Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene F-box DNA helicase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Increase of CD25 expression on bovine neutrophils correlates with disease severity in post-partum and early lactating dairy cows. Zoldan K, et al. Dev Comp Immunol, 2014 Dec. PMID 25106916
    2. Cloning of cDNA for the bovine IL-2 receptor (bovine Tac antigen). Weinberg AD, et al. Immunology, 1988 Apr. PMID 2835311, Free PMC Article
    3. Prostaglandin E₂ down-regulates the expression of CD25 on bovine T cells, and this effect is mediated through the EP4 receptor. Maślanka T, et al. Vet Immunol Immunopathol, 2014 Aug 15. PMID 25001909
    4. Foxp3 expression in bovine CD8+ T cells is associated with the intensity of CD25 expression. Maślanka T, et al. J Vet Med Sci, 2013 Feb. PMID 23059841
    5. Proinflammatory cytokines in bovine colostrum potentiate the mitogenic response of peripheral blood mononuclear cells from newborn calves through IL-2 and CD25 expression. Yamanaka H, et al. Microbiol Immunol, 2003. PMID 12906107

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Differential expression of CD25 and IDO mRNA with high and low virulence bovine viral diarrhea virus might reflect temporal differences in transcription during the immune response elicited by these viral strains.
      Title: Analysis of mRNA expression for genes associated with regulatory T lymphocytes (CD25, FoxP3, CTLA4, and IDO) after experimental infection with bovine viral diarrhea virus of low or high virulence in beef calves.
    2. Increase of CD25 expression on bovine neutrophils correlates with mastitis severity in post-partum and early lactating dairy cows.
      Title: Increase of CD25 expression on bovine neutrophils correlates with disease severity in post-partum and early lactating dairy cows.
    3. The PGE2-mediated down-regulation of CD25 expression on T cells is mediated via the EP4 receptor, although selective activation of the EP2 receptor up-regulates the CD25 expression on these cells.
      Title: Prostaglandin E₂ down-regulates the expression of CD25 on bovine T cells, and this effect is mediated through the EP4 receptor.
    4. There is a positive correlation between the intensity of CD25 expression and the expression of the transcription Foxp3 factor in bovine CD8(+) cells.
      Title: Foxp3 expression in bovine CD8+ T cells is associated with the intensity of CD25 expression.
    5. These findings revealed that despite the existence of a distinct bovine CD4(+)CD25(high) T cell population, which showed Foxp3 transcription/expression, natural regulatory activity did not reside in this cell population
      Title: Subpopulations of bovine WC1(+) gammadelta T cells rather than CD4(+)CD25(high) Foxp3(+) T cells act as immune regulatory cells ex vivo.
    6. Pretreatment of neonatal PBMC with IL-1beta, TNF-alpha or IFN-gamma promotes mitogenic response to ConA through up-regulating the production of IL-2 and the expression of the mature IL-2 receptor.
      Title: Proinflammatory cytokines in bovine colostrum potentiate the mitogenic response of peripheral blood mononuclear cells from newborn calves through IL-2 and CD25 expression.
    7. determined the effects of Mycobacterium-induced proliferation and apoptosis on CD25, CD44, and CD62L expression on peripheral blood T-cell subsets from M. bovis-infected cattle.
      Title: Expression of L-Selectin (CD62L), CD44, and CD25 on activated bovine T cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC155054

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables interleukin-2 binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables interleukin-2 receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interleukin-2 receptor subunit alpha
    Names
    IL-2 receptor alpha subunit
    IL-2 receptor subunit alpha
    IL-2-RA
    IL-2R alpha
    IL-2R subunit alpha
    IL2-RA
    TAC antigen
    cytokine receptor
    interleukin 2 receptor, alpha
    interleukin-2 receptor alpha chain
    p55

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174358.2 → NP_776783.1  interleukin-2 receptor subunit alpha precursor

      See identical proteins and their annotated locations for NP_776783.1

      Status: PROVISIONAL

      Source sequence(s)
      M20818
      UniProtKB/Swiss-Prot
      P12342
      UniProtKB/TrEMBL
      A0AAA9SP31
      Related
      ENSBTAP00000092190.1, ENSBTAT00000129500.1
      Conserved Domains (1) summary
      cd00033
      Location:123 → 185
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      17455219..17500715
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005214133.5 → XP_005214190.1  interleukin-2 receptor subunit alpha isoform X1

      See identical proteins and their annotated locations for XP_005214190.1

      UniProtKB/TrEMBL
      A0AAA9SP31, A2VE30, E1BEN0, F1MUD7
      Related
      ENSBTAP00000051522.3, ENSBTAT00000054113.4
      Conserved Domains (1) summary
      cd00033
      Location:123 → 185
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P12342.1 GenPept UniProtKB/Swiss-Prot:P12342

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.