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    IL12B interleukin 12B [ Bos taurus (domestic cattle) ]

    Gene ID: 281857, updated on 4-Oct-2024

    Summary

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    Official Symbol
    IL12Bprovided by VGNC
    Official Full Name
    interleukin 12Bprovided by VGNC
    Primary source
    VGNC:VGNC:30111
    See related
    BGD:BT12383; Ensembl:ENSBTAG00000004741
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    IL12p40
    Orthologs
    human mouse all
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    Genomic context

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    See IL12B in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (70891451..70911791, complement)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 145 Neighboring gene ubiquitin like domain containing CTD phosphatase 1 Neighboring gene U4 spliceosomal RNA Neighboring gene transfer RNA cysteine (anticodon ACA)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bovine interleukin-12 and modulation of IFNgamma production. Collins RA, et al. Vet Immunol Immunopathol, 1999 May. PMID 10438320
    2. Production of interleukin-12 as a self-processing 2A polypeptide. Chaplin PJ, et al. J Interferon Cytokine Res, 1999 Mar. PMID 10213462
    3. Enzymatic amplification and molecular cloning of cDNA encoding the small and large subunits of bovine interleukin 12. Zarlenga DS, et al. Biochim Biophys Acta, 1995 Apr 24. PMID 7727547
    4. Mycobacterium avium subspecies paratuberculosis suppresses expression of IL-12p40 and iNOS genes induced by signalling through CD40 in bovine monocyte-derived macrophages. Sommer S, et al. Vet Immunol Immunopathol, 2009 Mar 15. PMID 19022505
    5. Development of detection methods for ruminant interleukin (IL)-12. Hope JC, et al. J Immunol Methods, 2002 Aug 1. PMID 12133628

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results showed that the expression of TNF-alpha, iNOS, and IL-6 in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 was unaffected.[IL-6, IL-12]
      Title: Effect of recombinant Mce4A protein of Mycobacterium bovis on expression of TNF-alpha, iNOS, IL-6, and IL-12 in bovine alveolar macrophages.
    2. study investigated hypothesis that CD40 signalling is impaired in Mycobacterium avium subspecies paratuberculosis(MAP)-infected macrophages; propose that MAP interferes with gene expression of iNOS and IL-12p40 genes downstream of p38
      Title: Mycobacterium avium subspecies paratuberculosis suppresses expression of IL-12p40 and iNOS genes induced by signalling through CD40 in bovine monocyte-derived macrophages.
    3. Lipopolysaccharide stimulation up-regulates the secretion of cytokines, including interleukin-12, by bovine polymorphonuclear neutrophil leukocytes.
      Title: Bacterial lipopolysaccharide stimulates bovine neutrophil production of TNF-alpha, IL-1beta, IL-12 and IFN-gamma.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cytokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immunoglobulin mediated immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interleukin-12 subunit beta
    Names
    CLMF p40
    IL-12 subunit p40
    IL-12B
    cytotoxic lymphocyte maturation factor 40 kDa subunit
    interleukin 12 40kDa subunit
    interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174356.1 → NP_776781.1  interleukin-12 subunit beta precursor

      See identical proteins and their annotated locations for NP_776781.1

      Status: PROVISIONAL

      Source sequence(s)
      U11815
      UniProtKB/Swiss-Prot
      A9QWR4, P46282
      Conserved Domains (4) summary
      smart00408
      Location:42 → 90
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:42 → 91
      IG_like; Immunoglobulin like
      cd00063
      Location:236 → 324
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam10420
      Location:126 → 217
      IL12p40_C; Cytokine interleukin-12p40 C-terminus

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      70891451..70911791 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010807562.4 → XP_010805864.3  interleukin-12 subunit beta isoform X1

    2. XM_005209679.5 → XP_005209736.2  interleukin-12 subunit beta isoform X2

      UniProtKB/TrEMBL
      A0A3Q1LXM0
      Related
      ENSBTAP00000060277.1, ENSBTAT00000077926.2
      Conserved Domains (3) summary
      smart00408
      Location:42 → 90
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:236 → 324
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam10420
      Location:126 → 217
      IL12p40_C; Cytokine interleukin-12p40 C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46282.1 GenPept UniProtKB/Swiss-Prot:P46282

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials