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    CNGA1 cyclic nucleotide gated channel subunit alpha 1 [ Bos taurus (cattle) ]

    Gene ID: 281700, updated on 16-Jun-2024

    Summary

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    Official Symbol
    CNGA1provided by VGNC
    Official Full Name
    cyclic nucleotide gated channel subunit alpha 1provided by VGNC
    Primary source
    VGNC:VGNC:27497
    See related
    Ensembl:ENSBTAG00000002205
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    CNG; CNCG1
    Orthologs
    human mouse all
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    Genomic context

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    See CNGA1 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 6 NC_037333.1 (66668903..66706869, complement)

    Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene corin, serine peptidase Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene nuclear transcription factor, X-box binding like 1 Neighboring gene NIPA like domain containing 1 Neighboring gene TXK tyrosine kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of CNGA1 Channel Gating by Interactions with the Membrane. Aman TK, et al. J Biol Chem, 2016 May 6. PMID 26969165, Free PMC Article
    2. A structural, functional, and computational analysis suggests pore flexibility as the base for the poor selectivity of CNG channels. Napolitano LM, et al. Proc Natl Acad Sci U S A, 2015 Jul 7. PMID 26100907, Free PMC Article
    3. Conformational rearrangements in the transmembrane domain of CNGA1 channels revealed by single-molecule force spectroscopy. Maity S, et al. Nat Commun, 2015 May 12. PMID 25963832, Free PMC Article
    4. A ring of threonines in the inner vestibule of the pore of CNGA1 channels constitutes a binding site for permeating ions. Marchesi A, et al. J Physiol, 2012 Oct 15. PMID 22869010, Free PMC Article
    5. Conformational rearrangements in the S6 domain and C-linker during gating in CNGA1 channels. Nair AV, et al. Eur Biophys J, 2009 Sep. PMID 19488745

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The structure of the native CNGA1/CNGB1 CNG channel from bovine retinal rods.
      Title: The structure of the native CNGA1/CNGB1 CNG channel from bovine retinal rods.
    2. These results suggest that restraining the A' helix to the plasma membrane potentiates CNGA1 channel opening.
      Title: Regulation of CNGA1 Channel Gating by Interactions with the Membrane.
    3. Conformation changes of CNGA1 associated with its gating function are reported.
      Title: Conformational rearrangements in the transmembrane domain of CNGA1 channels revealed by single-molecule force spectroscopy.
    4. Data show that when Pro365 is replaced with a threonine in cyclic nucleotide gated channel alpha 1 (CNGA1), cesium Cs+ permeation is nearly abolished.
      Title: A structural, functional, and computational analysis suggests pore flexibility as the base for the poor selectivity of CNG channels.
    5. Stabilizing the C-helix of intact CNGA1 channels by metal binding to a pair of histidines promoted channel opening.
      Title: A secondary structural transition in the C-helix promotes gating of cyclic nucleotide-regulated ion channels.
    6. A ring of threonines in the inner vestibule of the pore of CNGA1 channels constitutes a binding site for permeating ions
      Title: A ring of threonines in the inner vestibule of the pore of CNGA1 channels constitutes a binding site for permeating ions.
    7. Three CNGA1 subunits and a single CNGB1 subunit form the rod cyclic nucleotide-gated ion channels.
      Title: Molecular mechanism for 3:1 subunit stoichiometry of rod cyclic nucleotide-gated ion channels.
    8. Existence of a strong coupling between the upper portion of the S6 helix provides a simple molecular mechanism for CNGA1 gating.
      Title: The analysis of desensitizing CNGA1 channels reveals molecular interactions essential for normal gating.
    9. detailed analysis of conformational changes of the S6 domain and C-linker during gating of CNGA1 channels
      Title: Conformational rearrangements in the S6 domain and C-linker during gating in CNGA1 channels.
    10. analyze in detail the molecular mechanisms underlying Cd2+ inhibition and longer cross-linkers in mutant CNGA1 channels
      Title: Movements of native C505 during channel gating in CNGA1 channels.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cGMP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables intracellularly cAMP-activated cation channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables intracellularly cGMP-activated cation channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of intracellular cyclic nucleotide activated cation channel complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclic nucleotide-gated channel alpha-1
    Names
    CNG channel alpha-1
    CNG-1
    CNG1
    cGMP-gated cation channel alpha-1
    cyclic nucleotide gated chanel (photoreceptor), cGMP gated 1, alpha
    cyclic nucleotide gated channel (photoreceptor), cGMP gated
    cyclic nucleotide gated channel alpha 1
    cyclic nucleotide-gated cation channel 1
    cyclic nucleotide-gated channel, photoreceptor
    rod photoreceptor cGMP-gated cation channel subunit alpha
    rod photoreceptor cGMP-gated channel subunit alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174278.2 → NP_776703.1  cyclic nucleotide-gated channel alpha-1

      See identical proteins and their annotated locations for NP_776703.1

      Status: PROVISIONAL

      Source sequence(s)
      X51604
      UniProtKB/Swiss-Prot
      Q00194
      Related
      ENSBTAP00000002853.5, ENSBTAT00000002853.7
      Conserved Domains (4) summary
      COG0664
      Location:471 → 602
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:477 → 588
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:185 → 405
      Ion_trans; Ion transport protein
      pfam16526
      Location:593 → 663
      CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      66668903..66706869 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q00194.1 GenPept UniProtKB/Swiss-Prot:Q00194

    Gene LinkOut

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