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    CAPN1 calpain 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 281661, updated on 4-Oct-2024

    Summary

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    Official Symbol
    CAPN1provided by VGNC
    Official Full Name
    calpain 1provided by VGNC
    Primary source
    VGNC:VGNC:26740
    See related
    BGD:BT12276; Ensembl:ENSBTAG00000010230
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    CANP1; CANP 1
    Orthologs
    human mouse all
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    Genomic context

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    See CAPN1 in Genome Data Viewer
    Location:
    chromosome: 29
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 29 NC_037356.1 (43399902..43427419)

    Chromosome 29 - NC_037356.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L49 Neighboring gene synoviolin 1 Neighboring gene speedy/RINGO cell cycle regulator family member C Neighboring gene microRNA mir-2407 Neighboring gene solute carrier family 22 member 20 Neighboring gene DNA polymerase alpha 2, accessory subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Production and processing studies on calpain-system gene markers for tenderness in Brahman cattle: 1. Growth, efficiency, temperament, and carcass characteristics. Cafe LM, et al. J Anim Sci, 2010 Sep. PMID 20525933
    2. Two-stage autolysis of the catalytic subunit initiates activation of calpain I. Zimmerman UJ, et al. Biochim Biophys Acta, 1991 Jun 24. PMID 2065086
    3. Bovine CAPN1 maps to a region of BTA29 containing a quantitative trait locus for meat tenderness. Smith TP, et al. J Anim Sci, 2000 Oct. PMID 11048924
    4. The calpain 1-alpha-actinin interaction. Resting complex between the calcium-dependent protease and its target in cytoskeleton. Raynaud F, et al. Eur J Biochem, 2003 Dec. PMID 14622253
    5. Bovine mu-calpain (CAPN1) gene: new SNP within intron 14. Juszczuk-Kubiak E, et al. J Appl Genet, 2004. PMID 15523157

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Most heifer reproductive traits were not significantly affected by CAST and CAPN1 markers that are widely used to improve beef tenderness by selection and breeders should not be concerned with how these markers affect reproduction and other heifer traits with the possible exception of CAPN1 effects on calving date.
      Title: μ-Calpain (CAPN1), calpastatin (CAST), and growth hormone receptor (GHR) genetic effects on Angus beef heifer performance traits and reproduction.
    2. study is the first report on genetic variant g.-1256 A>C in the promoter region of CAPN1 gene association with the semen quality of Chinese Holstein bulls by influencing its expression
      Title: A g.-1256 A>C in the promoter region of CAPN1 is associated with semen quality traits in Chinese Holstein bulls.
    3. These results suggest an important role of genetics in meat color variation for cattle raised under the tropic conditions.
      Title: Association of single nucleotide polymorphisms in CAPN1, CAST and MB genes with meat color of Brahman and crossbreed cattle.
    4. This work is supportive of the importance of CAPN1 and CAST for mean tenderness in beef.
      Title: CAPN1, CAST, and DGAT1 genetic effects on preweaning performance, carcass quality traits, and residual variance of tenderness in a beef cattle population selected for haplotype and allele equalization.
    5. Suppression of CANP1 resulted in the activation of caspase and heat-shock-protein systems which might in turn regulate apoptosis through the caspase-dependent cell death pathway. [CANP1]
      Title: Significant role of μ-calpain (CANP1) in proliferation/survival of bovine skeletal muscle satellite cells.
    6. bovine CAPN-CAST interaction were well reflected in the geometry between the pharmacophore features and its shape constraints identified using our modeled bovine CAPN1/CAST4 complex structures
      Title: Understanding the interaction determinants of CAPN1 inhibition by CAST4 from bovines using molecular modeling techniques.
    7. This work confirms the importance of CAPN1 and CAST for tenderness in beef, provides a new effect of CAST on beef tenderness, and questions the utility of GHR as a selection marker for beef quality.
      Title: μ-Calpain, calpastatin, and growth hormone receptor genetic effects on preweaning performance, carcass quality traits, and residual variance of tenderness in Angus cattle selected to increase minor haplotype and allele frequencies.
    8. It was found that the marker c.3379G > A in the CAPN1 gene influences the Ca content in the meat of this Nelore population, with the rare genotype associated with less Ca content.
      Title: Calcium and potassium content in beef: influences on tenderness and associations with molecular markers in Nellore cattle.
    9. m- and micro-calpain immunosignals in the cytoplasm both along the Z disk/I band regions and in the form of intracellular stores.
      Title: Immunological detection of m- and µ-calpains in the skeletal muscle of Marchigiana cattle.
    10. Association of polymorphisms in calpain 1, (mu/I) large subunit, calpastatin, and cathepsin D genes with meat quality traits in double-muscled Piemontese cattle.
      Title: Association of polymorphisms in calpain 1, (mu/I) large subunit, calpastatin, and cathepsin D genes with meat quality traits in double-muscled Piemontese cattle.
    Submit: New GeneRIF Correction See all GeneRIFs (29)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium-dependent cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calpain-1 catalytic subunit
    Names
    calcium activated neutral protease 1
    calcium-activated neutral proteinase 1
    calpain 1, (mu/I) large subunit
    calpain mu-type
    calpain-1 large subunit
    micromolar calcium-activated neutral protease 1
    micromolar-calpain
    mu-calpain
    muCANP
    NP_776684.1
    XP_024842740.1
    XP_024842741.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174259.2 → NP_776684.1  calpain-1 catalytic subunit

      See identical proteins and their annotated locations for NP_776684.1

      Status: PROVISIONAL

      Source sequence(s)
      AF221129
      UniProtKB/Swiss-Prot
      Q27970, Q9N0U3, Q9N0V6, Q9N185
      UniProtKB/TrEMBL
      A0A3Q1M124
      Related
      ENSBTAP00000063391.2, ENSBTAT00000087345.2
      Conserved Domains (3) summary
      cd00214
      Location:366 → 526
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      pfam00648
      Location:56 → 352
      Peptidase_C2; Calpain family cysteine protease
      cd16198
      Location:548 → 716
      EFh_PEF_CAPN1; Penta-EF hand, calcium binding motifs, found in mu-type calpain (CAPN1)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037356.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      43399902..43427419
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024986972.2 → XP_024842740.1  calpain-1 catalytic subunit isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M124
      Related
      ENSBTAP00000091522.1, ENSBTAT00000130093.1
      Conserved Domains (3) summary
      cd00214
      Location:366 → 526
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      pfam00648
      Location:56 → 352
      Peptidase_C2; Calpain family cysteine protease
      cd16198
      Location:548 → 716
      EFh_PEF_CAPN1; Penta-EF hand, calcium binding motifs, found in mu-type calpain (CAPN1)

    2. XM_024986973.2 → XP_024842741.1  calpain-1 catalytic subunit isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M124
      Conserved Domains (3) summary
      cd00214
      Location:366 → 526
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      pfam00648
      Location:56 → 352
      Peptidase_C2; Calpain family cysteine protease
      cd16198
      Location:548 → 716
      EFh_PEF_CAPN1; Penta-EF hand, calcium binding motifs, found in mu-type calpain (CAPN1)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q27970.3 GenPept UniProtKB/Swiss-Prot:Q27970

    Gene LinkOut

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    Research Materials