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    DPP4 dipeptidyl peptidase 4 [ Bos taurus (domestic cattle) ]

    Gene ID: 281122, updated on 10-Oct-2024

    Summary

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    Official Symbol
    DPP4provided by VGNC
    Official Full Name
    dipeptidyl peptidase 4provided by VGNC
    Primary source
    VGNC:VGNC:106715
    See related
    Ensembl:ENSBTAG00000048246
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    ACT3; CD26; WC10; DPPIV; ADCP-I
    Orthologs
    human mouse all
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    Genomic context

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    See DPP4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (34382851..34467589)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene fibroblast activation protein alpha Neighboring gene uncharacterized LOC112442563 Neighboring gene glucagon Neighboring gene solute carrier family 4 member 10 Neighboring gene ribulose-phosphate 3-epimerase-like Neighboring gene ATP synthase subunit f, mitochondrial-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proline-rich cytokine from neurosecretory granules: a new natural substrate for dipeptidyl peptidase IV. Antonyan AA, et al. Neurochem Res, 2011 Jan. PMID 20838887
    2. Purification and characterization of dipeptidyl peptidase IV-like enzymes from bovine testes. Dubois V, et al. Front Biosci, 2008 May 1. PMID 18508455
    3. Molecular characterization of bovine CD26 upregulated by a staphylococcal superantigen. Lee SU, et al. Immunogenetics, 2002 Jun. PMID 12073152
    4. Identity of activation molecule 3 on superantigen-stimulated bovine cells is CD26. Lee SU, et al. Infect Immun, 2001 Nov. PMID 11598101, Free PMC Article
    5. CD26 is expressed on a restricted subpopulation of dendritic cells in vivo. Gliddon DR, et al. Eur J Immunol, 2002 May. PMID 11981836

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results describe a proline-rich cytokine from neurosecretory granules that represents a new natural substrate for Dipeptidyl Peptidase IV (DPPIV).
      Title: Proline-rich cytokine from neurosecretory granules: a new natural substrate for dipeptidyl peptidase IV.
    2. Data demonstrate that dipeptidyl peptidase II can form a complex with adenosine deaminase, but with one order of magnitude higher dissociation constant than that of DPPIV.
      Title: Complex of dipeptidyl peptidase II with adenosine deaminase.
    3. This and other dipeptidyl peptidases can be isolated from bovine testes.
      Title: Purification and characterization of dipeptidyl peptidase IV-like enzymes from bovine testes.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables dipeptidyl-peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dipeptidyl peptidase 4
    Names
    T-cell activation antigen CD26
    activation molecule 3
    adenosine deaminase complexing protein
    dipeptidyl peptidase IV
    dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2)
    dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)
    NP_776464.1
    XP_059747274.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174039.3 → NP_776464.1  dipeptidyl peptidase 4

      See identical proteins and their annotated locations for NP_776464.1

      Status: PROVISIONAL

      Source sequence(s)
      AF461806
      UniProtKB/Swiss-Prot
      P81425, Q3ZCC2, Q8WMG8
      UniProtKB/TrEMBL
      A0AAF6ZJE9
      Related
      ENSBTAP00000049191.4, ENSBTAT00000056886.4
      Conserved Domains (3) summary
      COG1506
      Location:397 → 763
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00326
      Location:558 → 762
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:107 → 477
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      34382851..34467589
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059891291.1 → XP_059747274.1  dipeptidyl peptidase 4 isoform X1

      Related
      ENSBTAP00000084221.1, ENSBTAT00000110680.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P81425.3 GenPept UniProtKB/Swiss-Prot:P81425

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.