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    CD8A CD8 subunit alpha [ Bos taurus (domestic cattle) ]

    Gene ID: 281060, updated on 4-Oct-2024

    Summary

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    Official Symbol
    CD8Aprovided by VGNC
    Official Full Name
    CD8 subunit alphaprovided by VGNC
    Primary source
    VGNC:VGNC:27052
    See related
    BGD:BT12138; Ensembl:ENSBTAG00000021141
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See CD8A in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (48118177..48125250)

    Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene TBP protein-like pseudogene Neighboring gene CD8 subunit beta Neighboring gene required for meiotic nuclear division 5 homolog A Neighboring gene ring finger protein 103

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning, reconstruction and expression of the gene encoding the alpha-chain of the bovine CD8--definition of three peptide regions conserved across species. Lalor P, et al. Immunology, 1992 May. PMID 1628904, Free PMC Article
    2. Calyculin A inhibits expression of CD8alpha but not CD4 in human peripheral blood T cells. Allam A, et al. Immunobiology, 2000 Nov. PMID 11131152
    3. Zinc is essential for binding of p56(lck) to CD4 and CD8alpha. Lin RS, et al. J Biol Chem, 1998 Dec 4. PMID 9830036
    4. Molecular biology and function of CD4 and CD8. Parnes JR. Adv Immunol, 1989. PMID 2493728
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    General protein information

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    Preferred Names
    T-cell surface glycoprotein CD8 alpha chain
    Names
    CD8 antigen, alpha polypeptide (p32)
    CD8a molecule

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174015.1 → NP_776440.1  T-cell surface glycoprotein CD8 alpha chain precursor

      See identical proteins and their annotated locations for NP_776440.1

      Status: PROVISIONAL

      Source sequence(s)
      X59416
      UniProtKB/Swiss-Prot
      P31783
      Related
      ENSBTAP00000028175.3, ENSBTAT00000028175.4
      Conserved Domains (2) summary
      smart00410
      Location:32 → 133
      IG_like; Immunoglobulin like
      cl11960
      Location:35 → 138
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      48118177..48125250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P31783.1 GenPept UniProtKB/Swiss-Prot:P31783

    Gene LinkOut

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    Research Materials