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    PLG plasminogen [ Bos taurus (domestic cattle) ]

    Gene ID: 280897, updated on 4-Oct-2024

    Summary

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    Gene symbol
    PLG
    Gene description
    plasminogen
    See related
    Ensembl:ENSBTAG00000001271
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    LPA
    Orthologs
    human mouse all
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    Genomic context

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    See PLG in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 9 NC_037336.1 (96575186..96622803, complement)

    Chromosome 9 - NC_037336.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 member 2 Neighboring gene solute carrier family 22 member 3 Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene uncharacterized LOC112448109 Neighboring gene mitogen-activated protein kinase kinase kinase 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037336.1 Chromosome 9 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Complex interactions between bovine plasminogen and streptococcal plasminogen activator PauA. Ward PN, et al. J Mol Biol, 2004 Sep 24. PMID 15351638
    2. Complete amino acid sequence of bovine plasminogen. Comparison with human plasminogen. Schaller J, et al. Eur J Biochem, 1985 Jun 3. PMID 3846532
    3. Streptococcus uberis plasminogen activator (SUPA) activates human plasminogen through novel species-specific and fibrin-targeted mechanisms. Zhang Y, et al. J Biol Chem, 2012 Jun 1. PMID 22518846, Free PMC Article
    4. TNFalpha-mediated plasminogen activation on neutrophils is involved in the high plasmin activity in mammary secretion of drying-off cows. Chou WK, et al. J Dairy Res, 2009 Nov. PMID 19638263
    5. Acute heat stress brings down milk secretion in dairy cows by up-regulating the activity of the milk-borne negative feedback regulatory system. Silanikove N, et al. BMC Physiol, 2009 Jun 29. PMID 19563620, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SUPA formed a higher avidity complex (118-fold) with bovine Pg than with human Pg and non-proteolytically activated bovine but not human Pg.
      Title: Streptococcus uberis plasminogen activator (SUPA) activates human plasminogen through novel species-specific and fibrin-targeted mechanisms.
    2. The plasminogen/plasminogen activator/plasmin system is activated during gamete interaction and regulates the sperm entry into the oocyte.
      Title: Fertilization outcome could be regulated by binding of oviductal plasminogen to oocytes and by releasing of plasminogen activators during interplay between gametes.
    3. The current study suggests the existence of an active TNF-alpha-plasminogen-plasmin autocrine/paracrine loop on the massively infiltrated polymorphonuclear neutrophils inside udders of drying-off cows.
      Title: TNFalpha-mediated plasminogen activation on neutrophils is involved in the high plasmin activity in mammary secretion of drying-off cows.
    4. examination of interaction with streptococcal plasminogen activator PauA
      Title: Complex interactions between bovine plasminogen and streptococcal plasminogen activator PauA.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extrinsic component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    plasminogen
    Names
    lipoprotein, Lp(a)
    plasmin
    NP_776376.1
    XP_005211143.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173951.2 → NP_776376.1  plasminogen precursor

      See identical proteins and their annotated locations for NP_776376.1

      Status: PROVISIONAL

      Source sequence(s)
      X79402
      UniProtKB/Swiss-Prot
      P06868, Q28162
      UniProtKB/TrEMBL
      E1B726
      Related
      ENSBTAP00000001674.6, ENSBTAT00000001674.7
      Conserved Domains (5) summary
      smart00020
      Location:583 → 805
      Tryp_SPc; Trypsin-like serine protease
      smart00130
      Location:382 → 463
      KR; Kringle domain
      cd00190
      Location:584 → 808
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cd01099
      Location:40 → 104
      PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...
      pfam00051
      Location:192 → 269
      Kringle; Kringle domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037336.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      96575186..96622803 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005211086.5 → XP_005211143.1  plasminogen isoform X1

      See identical proteins and their annotated locations for XP_005211143.1

      UniProtKB/TrEMBL
      A7E350, E1B726, F1MTM6
      Related
      ENSBTAP00000051417.2, ENSBTAT00000053284.3
      Conserved Domains (5) summary
      smart00020
      Location:583 → 675
      Tryp_SPc; Trypsin-like serine protease
      smart00130
      Location:382 → 463
      KR; Kringle domain
      cd00190
      Location:584 → 675
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cd01099
      Location:40 → 104
      PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...
      pfam00051
      Location:192 → 269
      Kringle; Kringle domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06868.2 GenPept UniProtKB/Swiss-Prot:P06868

    Gene LinkOut

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