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    LTF lactotransferrin [ Bos taurus (cattle) ]

    Gene ID: 280846, updated on 7-Jul-2024

    Summary

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    Official Symbol
    LTFprovided by VGNC
    Official Full Name
    lactotransferrinprovided by VGNC
    Primary source
    VGNC:VGNC:31077
    See related
    BGD:BT26175; Ensembl:ENSBTAG00000001292
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    Lf
    Orthologs
    human mouse all
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    Genomic context

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    See LTF in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (52953232..52986625)

    Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene cripto, EGF-CFC family member Neighboring gene leucine rich repeat containing 2 Neighboring gene receptor transporter protein 3 Neighboring gene C-C motif chemokine receptor like 2 Neighboring gene C-C motif chemokine receptor 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lactoferrin gene polymorphisms associated with clinical mastitis in Honduran Holstein inheritance cows. Moncada-Laínez M, et al. Mol Biol Rep, 2023 Feb. PMID 36385664
    2. Bovine Lactoferrin can Decrease the In Vitro Biofilm Production and Show Synergy with Antibiotics Against Listeria and Escherichia coli Isolates. García-Borjas KA, et al. Protein Pept Lett, 2021. PMID 32242775
    3. Native and iron-saturated bovine lactoferrin differently hinder migration in a model of human glioblastoma by reverting epithelial-to-mesenchymal transition-like process and inhibiting interleukin-6/STAT3 axis. Cutone A, et al. Cell Signal, 2020 Jan. PMID 31678680
    4. Lactoferrin translocates to the nucleus of bovine rectal epithelial cells in the presence of Escherichia coli O157:H7. Rybarczyk J, et al. Vet Res, 2019 Oct 1. PMID 31570109, Free PMC Article
    5. DNase and RNase activities of fresh cow milk lactoferrin. Soboleva SE, et al. J Mol Recognit, 2019 Jul. PMID 30761635

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lactoferrin gene polymorphisms associated with clinical mastitis in Honduran Holstein inheritance cows.
      Title: Lactoferrin gene polymorphisms associated with clinical mastitis in Honduran Holstein inheritance cows.
    2. Bovine Lactoferrin can Decrease the In Vitro Biofilm Production and Show Synergy with Antibiotics Against Listeria and Escherichia coli Isolates.
      Title: Bovine Lactoferrin can Decrease the In Vitro Biofilm Production and Show Synergy with Antibiotics Against Listeria and Escherichia coli Isolates.
    3. Native and iron-saturated bovine lactoferrin differently hinder migration in a model of human glioblastoma by reverting epithelial-to-mesenchymal transition-like process and inhibiting interleukin-6/STAT3 axis.
      Title: Native and iron-saturated bovine lactoferrin differently hinder migration in a model of human glioblastoma by reverting epithelial-to-mesenchymal transition-like process and inhibiting interleukin-6/STAT3 axis.
    4. Results provide evidence that LTF possess metal-dependent DNase and metal-independent RNase activities. The discovery of LF nuclease activities may contribute to understanding the multiple physiological functions of this extremely polyfunctional LF including its protective role against microbial and viral infections.
      Title: DNase and RNase activities of fresh cow milk lactoferrin.
    5. Lactoferrin derived from bovine milk was internalized by rectal epithelial cells and translocated to the nuclei. Moreover, nuclear translocation of bLF was significantly enhanced when the epithelial cells were inoculated with EHEC, as demonstrated by confocal fluorescence microscopy and confirmed by Raman microscopy and 3D imaging.
      Title: Lactoferrin translocates to the nucleus of bovine rectal epithelial cells in the presence of Escherichia coli O157:H7.
    6. This research reveals the effectiveness of LTF/EcoRI and TLR4/AluI loci as candidates for reproductive performance assessment in Holstein cattle.
      Title: Genetic Polymorphisms in LTF/EcoRI and TLR4/AluI loci as candidates for milk and reproductive performance assessment in Holstein cattle.
    7. Taken together, our data allowed to better characterize the Influenza virus hemagglutinin-specific inhibiting activity of bLf and to confirm hemagglutinin as a good target for drug development.
      Title: Bovine Lactoferrin Prevents Influenza A Virus Infection by Interfering with the Fusogenic Function of Viral Hemagglutinin.
    8. study first addressed in detail the LF/fOPN interaction and proposed a LF:fOPN 4/1 maximal stoichiometry.
      Title: Reactivity of U-associated osteopontin with lactoferrin: a one-to-many complex.
    9. Retinoic acid enhanced TbetaRIII expression and that this increase contributed to LF-stimulated IgA production.
      Title: Retinoic acid enhances lactoferrin-induced IgA responses by increasing betaglycan expression.
    10. lactoferrin and glutamate receptor-interacting protein 1 showed a twofold increase during the controlled internal drug release -induced estrous stage compared to the levels in non-estrous stage in bovine cervical mucus
      Title: Identification of lactoferrin and glutamate receptor-interacting protein 1 in bovine cervical mucus: A putative marker for oestrous detection.
    Submit: New GeneRIF Correction See all GeneRIFs (74)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antibacterial humoral response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in antifungal humoral response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cytokine production IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lactotransferrin
    Names
    lactoferrin
    NP_851341.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_180998.2 → NP_851341.1  lactotransferrin precursor

      See identical proteins and their annotated locations for NP_851341.1

      Status: PROVISIONAL

      Source sequence(s)
      L08604
      UniProtKB/Swiss-Prot
      P24627, Q1JQC9, Q29629, Q6LEC7, Q9MZY3
      UniProtKB/TrEMBL
      B3VTM3, B9VPZ5
      Related
      ENSBTAP00000001704.4, ENSBTAT00000001704.6
      Conserved Domains (4) summary
      smart00094
      Location:364 → 693
      TR_FER; Transferrin
      cd13617
      Location:361 → 692
      PBP2_transferrin_C; The C-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily
      cd13618
      Location:24 → 351
      PBP2_transferrin_N; The N-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily
      pfam00405
      Location:25 → 352
      Transferrin; Transferrin

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      52953232..52986625
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P24627.2 GenPept UniProtKB/Swiss-Prot:P24627

    Gene LinkOut

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